Synthesis method of metixene hydrochloride
A technology of Mesaisan hydrochloride and a synthesis method, which is applied in the field of synthesis technology of anti-shock paralysis drugs, can solve the problems of high price of molybdenum trisulfide, does not conform to green chemistry, is unfavorable to industrialization, and achieves low cost, low price and production cost. reduced effect
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Embodiment 1
[0030] Synthesis of 2-phenylthiobenzoic acid (2)
[0031] KOH (54.5g, 972.7mmol) and 600ml H 2 O was made into a solution and cooled to room temperature. N 2 Under protection, the raw material thiosalicylic acid (30g, 389.1mmol) was added into a 1000ml three-neck flask, dissolved in the KOH solution prepared above and heated to 60°C and stirred for 30 minutes, N 2 Add cuprous bromide (1.675g, 11.6mmol) under protection, add iodobenzene, heat up to reflux, react for 20h, stop heating, cool the reaction solution to room temperature, add 100ml of concentrated hydrochloric acid dropwise, the time is 30min, and the pH value is 1 , a large number of yellow solids were generated, and the yellow solid was obtained by suction filtration, and the precipitate was washed with 2 × 500ml of water to obtain a white solid, which was dried to obtain the target product 2-phenylthiobenzoic acid (2) 85.5g, yield 95.5%
[0032] 1 HNMR (500MHz, CDCl 3 )8.2~8.4(d, 1H), 7.7~7.8(t, 2H), 7.5~7.6(t...
Embodiment 2
[0043] Synthesis of 2-phenylthiobenzoic acid (2)
[0044] KOH (54.5g, 972.7mmol) and 600ml H 2 O was made into a solution and cooled to room temperature. N 2 Under protection, the raw material thiosalicylic acid (1) (30g, 389.1mmol) was added into a 1000ml three-necked bottle, dissolved in the KOH solution prepared above and heated to 60°C and stirred for 30 minutes, N 2 Add cuprous iodide (2.2g, 11.6mmol) under protection, add iodobenzene, heat up to reflux, react for 20h, stop heating, cool the reaction solution to room temperature, add 100ml of concentrated hydrochloric acid dropwise, the time is 30min, and the pH value is 1 , a large number of yellow solids were generated, and the yellow solid was obtained by suction filtration, and the precipitate was washed with 2 × 500ml of water to obtain a white solid, which was dried to obtain the target product 2-phenylthiobenzoic acid (2) 85.5g, yield 95.5%
[0045] Synthesis of 9-thioxanthone (3)
[0046] N 2 Under protection...
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