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Method for preparing water soluble polyethylene glycol/polylactic segmented polycarbonate resin

A technology of polyethylene glycol and polycarbonate, which is applied in the field of preparation of water-soluble polyethylene glycol/polylactic acid multi-block polycarbonate, can solve the problems of inconvenient transportation and storage, and achieve low toxicity and wide application Prospect, effect of reducing side effects

Inactive Publication Date: 2009-09-16
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coupling agents such as diacid chloride or isocyanate are liquid at room temperature and have a strong pungent odor, making transportation and storage extremely inconvenient

Method used

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  • Method for preparing water soluble polyethylene glycol/polylactic segmented polycarbonate resin
  • Method for preparing water soluble polyethylene glycol/polylactic segmented polycarbonate resin
  • Method for preparing water soluble polyethylene glycol/polylactic segmented polycarbonate resin

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A preparation method of water-soluble polyethylene glycol / polylactic acid multi-block polycarbonate, the steps are as follows:

[0043] (1) Weigh 12.00g PEG6000 and 5.76g L-LA, and place them in a fully washed and dried three-necked flask. After 30 minutes of flowing nitrogen, start heating, and after melting into a homogeneous phase, add 0.88 g of stannous octoate, and react at 150°C for 24 hours under the protection of nitrogen. The product was dissolved in 10 mL of dichloromethane, and then 100 mL of methanol was added to obtain a white precipitate to obtain a PLA-PEG-PLA triblock copolymer.

[0044] (2) Take by weighing 4.44g PLA-PEG-PLA triblock copolymer and join in the round-bottomed flask that condenser tube, thermometer, constant pressure dropping funnel and magnetic force stirring are housed, and measure 15mL dichloromethane and pour into, Airtight, magnetic stirring to completely dissolve the solid, and an anhydrous calcium chloride drying tube on the conden...

Embodiment 2

[0051] As described in Example 1, the difference is that the amount of L-LA is changed, and 4.32g is dropped into to obtain 2.23g of a viscous solid product of water-soluble polycarbonate with a thermally reversible gel effect, the yield is 65.40%, and the weight average molecular weight for 51900.

Embodiment 3

[0053] As described in Example 1, the difference is that the amount of L-LA is changed, and 7.20 g is added to obtain 3.12 g of a viscous solid product of water-soluble polycarbonate with a thermally reversible gel effect, with a yield of 57.09%, and a weight-average molecular weight for 68500.

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Abstract

The invention provides a method for preparing a water soluble polyethylene glycol / polylactic segmented polycarbonate resin with thermal reversible gel effect by using solid phosgene as a coupling agent, which belongs to the technical field of water soluble polymer synthesis and degradable medical application. The method comprises the following steps that: under the catalytic action of stannous octoate, L-lactide is initiated to open by polyethylene glycol to synthesize a polylactic acid-polyethylene glycol-polylactic triblock copolymer containing a terminal hydroxy group; the triblock copolymer is subjected to chain extension by the solid phosgene to obtain polyethylene glycol / polylactic segmented polycarbonate resin; and the polyethylene glycol / polylactic segmented polycarbonate resin is precipitated and dried through a mixed solution of absolute methanol and absolute aether to obtain a viscous solid product. The copolymer has good water solubility and prominent reversible gel effect, and has wide application prospect in medicine slow release, tissue engineering and other fields.

Description

technical field [0001] The present invention relates to a preparation method of water-soluble polyethylene glycol / polylactic acid multi-block polycarbonate, especially a preparation method of water-soluble polyethylene glycol / polylactic acid multi-block polycarbonate with thermally reversible gel effect . Background technique [0002] Polylactic acid (PLA) is a polymer material with good biocompatibility and biodegradability, and has been widely used in tissue engineering and other biomedical fields. However, because PLA is a hydrophobic polymer, its adhesion to cells is poor, and its degradation cycle is difficult to control, which limits its application in tissue engineering. In order to improve the hydrophilicity of PLA, hydrophilic groups or segments can be introduced into the main chain of PLA. Polyethylene glycol (PEG) has good biocompatibility and hydrophilicity, and introducing PEG segments into PLA molecular chains is a better way to improve the hydrophilicity of ...

Claims

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Application Information

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IPC IPC(8): C08G63/664C08G63/64
Inventor 谭业邦王月霞
Owner SHANDONG UNIV
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