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Method for preparing polymer modified electrode for selectively measuring dopamine

A technology for modifying electrodes and dopamine, which is applied in the field of electrochemistry, can solve the problems of irreversible redox, unfavorable analysis and measurement, slow electrode reaction, etc., and achieve the effects of enhanced charge transfer and penetration, strong electrode modification layer, and long electrode life

Inactive Publication Date: 2009-11-11
NANJING UNIV OF TECH
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Problems solved by technology

However, in the process of electrochemical analysis of dopamine, the overpotential of dopamine on the bare electrode is high, the electrode reaction is slow, the redox is irreversible, and the peak shape is not good; dopamine itself and its reactants are easily adsorbed on the surface of the electrode, resulting in electrode passivation. The sensitivity is reduced, which is not conducive to its analysis and determination; in addition, the oxidation peak current of ascorbic acid (AA), another biological substance that coexists with dopamine, is very close to that of DA, which will seriously interfere with the determination of DA

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  • Method for preparing polymer modified electrode for selectively measuring dopamine
  • Method for preparing polymer modified electrode for selectively measuring dopamine
  • Method for preparing polymer modified electrode for selectively measuring dopamine

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Embodiment Construction

[0019] Pretreatment of the bare glassy carbon electrode: the surface of the glassy carbon electrode was polished with 1.0, 0.3 and 0.05 μm γ-alumina powder, and then ultrasonically washed in acetone and double distilled water, respectively, and finally the electrode was placed at room temperature to dry.

[0020] Preparation of Polygallic Acid Film Modified Electrode: In the presence of 2.0×10 -2 In the 0.1mol / L sulfuric acid solution of mol / L gallic acid, the scanning speed was 100mV / s in the potential range of -1.5V~0.8V for 20~30 circles (CHI660C electrochemical workstation, glassy carbon electrode as the working electrode, A platinum wire electrode was used as an auxiliary electrode, and a saturated calomel electrode (SCE) was used as a reference electrode). Take it out and wash it with double distilled water, put it into 0.1M pH7.4 phosphate buffer solution (PBS), sweep cyclic voltammetry in the potential window of -0.4V ~ 0.8V until the graph is stable, and wash it with ...

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Abstract

The invention discloses a method for preparing a polymer modified electrode for selectively measuring dopamine, which comprises the following steps: firstly, performing pretreatments of polishing, washing and drying on a glassy carbon electrode; secondly, putting the glassy carbon electrode into solution of gallic acid and sulfuric acid to perform cyclic scanning at an electric potential of between -1.5 and 0.8 volt; and thirdly, putting the glassy carbon electrode into a phosphate buffer solution to perform cyclic voltammetry scanning in an electric potential window at an electric potential of between -0.4 and 0.8 volt until the solution is stable. The method has advanced process, scientific material selection, and convenient and practicable manufacture, and the prepared electrode not only can selectively respond to DA, but also can well catalyze the DA to react on the electrode, improve the sensitivity of DA measurement, overcome the defect that the DA is diffused slowly in a Nafion membrane, and eliminate the interference of AA to DA detection.

Description

technical field [0001] The invention belongs to the field of electrochemistry, and in particular relates to a preparation method of a polygallic acid modified electrode. Background technique [0002] Dopamine (dopamine, DA, also known as 3-hydroxytyramine), as an important catecholamine neurotransmitter in the hypothalamus and pituitary gland, is the direct precursor of the synthesis of norepinephrine in the body. It plays an important role in the control and prevention of health and disease. DA levels are related to heart disease, blood pressure, thyroid hormone levels, and neuromuscular disorders. The study of DA determination method has important practical significance in clinical application and the exploration of its physiological mechanism, and it is particularly important to establish a high-sensitivity analysis method for selective determination of dopamine. [0003] Electrochemical determination has attracted widespread attention due to its advantages of fast spee...

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Application Information

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IPC IPC(8): G01N27/30
Inventor 田丹碧宋伟陈禹崔锐博
Owner NANJING UNIV OF TECH
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