Lacidipine tablets and preparation method thereof

Abstract

The invention provides lacidipine tablets and a preparation method thereof. The lacidipine tablets comprise 1-4% of lacidipine, 14-32% of hydroxypropyl cellulose or microcrystalline cellulose, 1-3% ofpoloxamer or sodium dodecyl sulfate or povidone or copovidone, 0.25-2% of magnesium stearate and the balance of lactose by weight percent, and the preparation method comprises the following steps ofevenly mixing raw material of the lacidipine with the lactose according to the weight ratio of 1:1 after ultra-fine smashing, further evenly mixing the mixture with the balance of the lactose and thehydroxypropyl cellulose or the microcrystalline cellulose, adding a water solution bonding agent prepared by the poloxamer or the odium dodecyl sulfate or the povidone or the copovidone, preparing appropriate soft materials, passing a 18-mesh sieve for granulation, drying at the temperature of 40-60 DEG C, passing a 16-mesh sieve for size stabilization, adding the magnesium stearate, evenly mixingand pressing tablets, thereby preparing products. The method can effectively improve the dissolution of the lacidipine tablets and lead the evenness index to achieve the more ideal value. The methodcan further improve the bioavailability of the lacidipine tablets and has the advantages of fast absorption, convenient administration and significant efficacy.

Description

(1) Technical field [0001] The present invention relates to a kind of medicine, and the present invention also relates to a kind of preparation method of medicine, specifically a kind of lacidipine tablet and preparation method thereof. (2) Background technology [0002] Lacidipine is a new type of dihydropyridine calcium antagonist, which can strongly inhibit calcium channels, has high selectivity to blood vessels, and has a long-lasting antihypertensive effect, especially when it is only taken once a day (4-6mg). Highly potent and long-lasting antihypertensive activity. Lacidipine, as an ideal drug for treating hypertension, has the advantages of definite curative effect, high selectivity to blood vessels, long-lasting antihypertensive effect, small toxic and side effects, low price, and few times of taking (only one tablet per day). [0003] Because lacidipine is a small-dose, insoluble drug, the dissolution rate and uniformity index of lacidipine tablets prepared by tra...

AI Technical Summary

Problems solved by technology

[0003] Since lacidipine is a small-dose, insoluble drug, the dissolution rate and uniformity index of lacidipine tablets prepared by traditional tablet production technology can not reach the ideal value.

And adopt solvent dispersion method to prepare lacidipine tablet, the one, just can make it dissolve completely with enough ethanol, but the soft material of making like this is too soft, the 2nd, with solvent dispersion method, lacidipine soluble component migrates, Make the content uniformity unqualified, thus affecting the curative effect of the product