Nano fiber artificial blood vessel for catalyzing endogenous NO precursor to release NO and preparation method
A technology of nanofibers and artificial blood vessels, which is applied in the field of biomedical applications of polymer materials, can solve problems such as unfavorable gelatin films, and achieve the effects of increasing solution viscosity, improving ability, and inhibiting platelet aggregation
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Embodiment 1
[0038] A nanofiber artificial blood vessel that catalyzes the release of NO from endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:
[0039] (1) dissolving gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:3:0.001 to make a solution with a gelatin mass fraction of 20%;
[0040] (2) Take 20 mL of the solution prepared in step (1), mix it with 1.0 mL of 55% glutaraldehyde aqueous solution to make it pre-crosslinked, and add 8 mL of 2.0% heparin sodium aqueous solution to prepare The spinning stock solution is loaded into the electrospinning equipment, and the electrospinning method is used to collect the formed fibers ejected from the spinning nozzle in the electrospinning equipment on the collection roller to form a nanofiber non-woven membrane tube;
[0041] (3) Polyurethane CorethaneTM and copper salt chelate ar...
Embodiment 2
[0044] A nanofiber artificial blood vessel that catalyzes the release of NO from endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:
[0045] (1) dissolving gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:3:0.01 to make a solution with a gelatin mass fraction of 20%;
[0046] (2) Take 20 mL of the solution prepared in step (1), mix it with 1.0 mL of 55% glutaraldehyde aqueous solution to make it pre-crosslinked, and add 8 mL of 2.0% heparin sodium aqueous solution to prepare The spinning stock solution is loaded into the electrospinning equipment, and the electrospinning method is used to collect the formed fibers ejected from the spinning nozzle in the electrospinning equipment on the collection roller to form a nanofiber non-woven membrane tube;
[0047] (3) Polyurethane CorethaneTM and copper salt chelate are...
Embodiment 3
[0050] A nanofiber artificial blood vessel that catalyzes the release of NO from endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:
[0051] (1) dissolving gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:3:0.02 to make a solution with a gelatin mass fraction of 20%;
[0052] (2) Take 20 mL of the solution prepared in step (1), mix it with 1.0 mL of 55% glutaraldehyde aqueous solution to make it pre-crosslinked, and add 8 mL of 2.0% heparin sodium aqueous solution to prepare The spinning stock solution is loaded into the electrospinning equipment, and the electrospinning method is used to collect the formed fibers ejected from the spinning nozzle in the electrospinning equipment on the collection roller to form a nanofiber non-woven membrane tube;
[0053] (3) dissolving polyurethane CorethaneTM and copper salt ...
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