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Nano fiber artificial blood vessel for catalyzing endogenous NO precursor to release NO and preparation method

A technology of nanofibers and artificial blood vessels, which is applied in the field of biomedical applications of polymer materials, can solve problems such as unfavorable gelatin films, and achieve the effects of increasing solution viscosity, improving ability, and inhibiting platelet aggregation

Active Publication Date: 2013-07-31
南通双辉医疗器械科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gelatin film shrinks and curls violently after cross-linking, which is not conducive to obtaining a flat gelatin film, and this problem has not been effectively solved

Method used

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  • Nano fiber artificial blood vessel for catalyzing endogenous NO precursor to release NO and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A nanofiber artificial blood vessel that catalyzes the release of NO from endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:

[0039] (1) dissolving gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:3:0.001 to make a solution with a gelatin mass fraction of 20%;

[0040] (2) Take 20 mL of the solution prepared in step (1), mix it with 1.0 mL of 55% glutaraldehyde aqueous solution to make it pre-crosslinked, and add 8 mL of 2.0% heparin sodium aqueous solution to prepare The spinning stock solution is loaded into the electrospinning equipment, and the electrospinning method is used to collect the formed fibers ejected from the spinning nozzle in the electrospinning equipment on the collection roller to form a nanofiber non-woven membrane tube;

[0041] (3) Polyurethane CorethaneTM and copper salt chelate ar...

Embodiment 2

[0044] A nanofiber artificial blood vessel that catalyzes the release of NO from endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:

[0045] (1) dissolving gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:3:0.01 to make a solution with a gelatin mass fraction of 20%;

[0046] (2) Take 20 mL of the solution prepared in step (1), mix it with 1.0 mL of 55% glutaraldehyde aqueous solution to make it pre-crosslinked, and add 8 mL of 2.0% heparin sodium aqueous solution to prepare The spinning stock solution is loaded into the electrospinning equipment, and the electrospinning method is used to collect the formed fibers ejected from the spinning nozzle in the electrospinning equipment on the collection roller to form a nanofiber non-woven membrane tube;

[0047] (3) Polyurethane CorethaneTM and copper salt chelate are...

Embodiment 3

[0050] A nanofiber artificial blood vessel that catalyzes the release of NO from endogenous NO precursors is composed of a three-dimensional network non-woven membrane tube structure formed by two layers of nanofibers inside and outside, and is made by the following method:

[0051] (1) dissolving gelatin, ascorbic acid and sodium nitrite in water at a mass ratio of 100:3:0.02 to make a solution with a gelatin mass fraction of 20%;

[0052] (2) Take 20 mL of the solution prepared in step (1), mix it with 1.0 mL of 55% glutaraldehyde aqueous solution to make it pre-crosslinked, and add 8 mL of 2.0% heparin sodium aqueous solution to prepare The spinning stock solution is loaded into the electrospinning equipment, and the electrospinning method is used to collect the formed fibers ejected from the spinning nozzle in the electrospinning equipment on the collection roller to form a nanofiber non-woven membrane tube;

[0053] (3) dissolving polyurethane CorethaneTM and copper salt ...

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Abstract

The invention discloses a nano fiber artificial blood vessel for catalyzing an endogenous NO precursor to release NO and a preparation method. The artificial blood vessel consists of a three-dimensional reticular non-woven film pipe structure formed by an inner layer of nano fibers and an outer layer of nano fibers. The artificial blood vessel is prepared by the method comprising the following steps of: dissolving gelatin, ascorbic acid and sodium nitrite in water to prepare a solution; uniformly mixing the prepared solution with an aqueous solution of a crosslinking agent to ensure that the solution is pre-crosslinked; adding a sodium heparin aqueous solution to prepare a spinning dope; collecting fibers formed by spinning on a collecting roller to form nano fiber non-woven film pipes; dissolving polyurethane and nantokite chelate in a mixed solvent of tetrahydrofuran and N,N-dimethyl fomamide to prepare a polyurethane spinning dope; spinning and continuing collecting fibers on the collecting roller with the nano fiber non-woven film pipes so as to form polyurethane non-woven film pipes; and soaking and treating the polyurethane non-woven film pipes in the aqueous solution of thecrosslinking agent. The blood vessel can catalyze to release NO for a long time and is beneficial to inhibiting the aggregation of platelets in the artificial blood vessel. The method is simple, and the degree of crosslinking is easy to control.

Description

technical field [0001] The invention belongs to the field of biomedical application of polymer materials, and relates to a nanofiber artificial blood vessel that catalyzes an endogenous NO precursor to release NO and a preparation method. Background technique [0002] Severe damage to human blood vessels has become a difficult problem in the medical field due to poor self-repair ability. Since the clinical success of artificial blood vessels made of vinylon in 1952, people have successively developed artificial blood vessels made of various materials. The commonly used transplanted blood vessels are mainly made of materials such as polyester, nylon and polytetrafluoroethylene, but these materials do not support the adhesion and growth of human endothelial cells, making it difficult to fully endothelialize the blood vessels implanted in the human body, and have a negative effect on the blood vessels. Long-term adaptation creates barriers. Therefore, this type of blood vessel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/22A61L27/18D01D1/02D01D5/00
Inventor 冯亚凯郭锦棠肖若芳
Owner 南通双辉医疗器械科技有限公司
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