Nanometer hydroxyapatite-based bioactive material and method for preparing same
A nano-hydroxyapatite and biologically active technology, which is applied in the field of modification of hydroxyapatite nanoparticles, can solve the problems that the mechanical properties of nanocomposites cannot be well controlled, it is difficult to meet the use requirements, and there are few active hydroxyl groups. Achieve convenient chemical modification method, excellent dispersion and stability, and improve the effect of dispersion and stability
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Embodiment 1
[0039] Example 1: HAP-PHEMA-(PCL) m Preparation of hybrid materials.
[0040] a) Preparation of HAP-Br by chemically bonding bromine initiator on HAP surface
[0041]Disperse 1g of nano-hydroxyapatite in 10ml of chloroform (transmission electron microscope photo see Figure 5 ,from Figure 5 It can be found that the agglomeration of nano-hydroxyapatite in dichloromethane is very serious). Under the condition of nitrogen protection, 0.6 g of α-bromoisobutyryl bromide solution diluted with 10 ml of chloroform was slowly added dropwise at a temperature between 0 and 3 °C, and reacted at room temperature for 24 h after the dropwise addition was completed. After the reaction, the mixture was diluted with chloroform, ultrasonically oscillated for 1 h, and centrifuged. The precipitate was repeatedly washed with chloroform and dried in vacuum to obtain nano-hydroxyapatite (HAP-Br) chemically bonded with bromine initiator. By solid-state carbon NMR spectroscopy (see figure 2 ) It...
Embodiment 2
[0046] Example 2: HAP-PHEA-(PCL-PLA) m Preparation of hybrid materials.
[0047] a) Preparation of HAP-Br by chemically bonding bromine initiator on HAP surface
[0048] Disperse 1 g of nano-hydroxyapatite in 10 ml of chloroform. Under the condition of nitrogen protection, 0.6 g of α-bromoisobutyryl bromide solution diluted with 10 ml of chloroform was slowly added dropwise at a temperature between 0 and 3 °C, and reacted at room temperature for 24 h after the dropwise addition was completed. After the reaction, the mixture was diluted with chloroform, ultrasonically oscillated for 1 h, centrifuged, the supernatant was discarded, the precipitate was repeatedly washed with chloroform, and vacuum-dried to obtain hydroxyapatite (HAP-Br) nanoparticles chemically bonded to the bromine initiator on the surface .
[0049] b) HAP-Br initiates the polymerization of 2-hydroxyethyl acrylate (HEA)
[0050] Under magnetic stirring, add 0.058g cuprous bromide (CuBr), 0.062g bipyridine (...
Embodiment 3
[0053] Example 3: HAP-PHEMA-PHEA-(PLA) m Preparation of hybrid materials
[0054] a) Preparation of HAP-Br by chemically bonding bromine initiator on HAP surface
[0055] Disperse 1 g of nano-hydroxyapatite in 10 ml of chloroform. Under the condition of nitrogen protection, 0.6 g of α-bromoisobutyryl bromide solution diluted with 10 ml of chloroform was slowly added dropwise at a temperature between 0 and 3 °C, and reacted at room temperature for 24 h after the dropwise addition was completed. After the reaction, the mixture was diluted with chloroform, ultrasonically oscillated for 1 h, and centrifuged. The precipitate was repeatedly washed with chloroform and dried in vacuum to obtain hydroxyapatite (HAP-Br) nanoparticles chemically bonded with bromine initiator.
[0056] b) Copolymerization of 2-hydroxyethyl acrylate and 2-hydroxyethyl methacrylate (HEMA) initiated by HAP-Br
[0057] Under magnetic stirring, 0.058g cuprous bromide (CuBr), 0.062g bipyridyl (bpy) and 1g b...
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