Injection of mannite and glycerol and preparation method thereof

A technology of mannitol and injection, which is applied in the field of mannitol and glycerin injection and its preparation, can solve the problems of hemolysis, electrolyte disorder, recovery and rebound, etc., achieve the inhibition of nerve cell apoptosis, mild and slow effect, and reduce intracranial pressure Effect

A technology of mannitol and injection, which is applied in the field of mannitol and glycerin injection and its preparation, can solve the problems of hemolysis, electrolyte disorder, recovery and rebound, etc., achieve the inhibition of nerve cell apoptosis, mild and slow effect, and reduce intracranial pressure Effect

CN101732287AActive Publication Date: 2010-06-16北京圣方达隆医药科技发展有限责任公司 +2
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  • Injection of mannite and glycerol and preparation method thereof
  • Injection of mannite and glycerol and preparation method thereof
  • Injection of mannite and glycerol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Mannitol glycerin injection, the ratio of each component is as follows:

[0043] Mannitol 18g

[0044] Glycerin 5g

[0045] Add water for injection to 100ml.

[0046] Preparation:

[0047] Dissolve mannitol and glycerin in an appropriate amount of water for injection; add 0.1-0.2% W / V activated carbon for needles, heat to boil, and filter; add the rest of water for injection, mix well, filter, fill and seal, and store at 121°C for 15 Minutes autoclave and ready to serve.

Embodiment 2

[0049] Mannitol glycerin injection, the ratio of each component is as follows:

[0050] Mannitol 15g

[0051] Glycerin 3g

[0052] Add water for injection to 100ml.

[0053] Preparation:

[0054] Dissolve mannitol and glycerin in an appropriate amount of water for injection; add 0.1-0.2% W / V activated carbon for needles, heat to boil, and filter; add the rest of water for injection, mix well, filter, fill and seal, and store at 121°C for 15 Minutes autoclave and ready to serve.

Embodiment 3

[0056] Mannitol glycerin injection, the ratio of each component is as follows:

[0057] Mannitol 15g

[0058] Glycerin 5g

[0059] Add water for injection to 100ml.

[0060] Preparation:

[0061] Dissolve mannitol and glycerin in an appropriate amount of water for injection; add 0.1-0.2% W / V activated carbon for needles, heat to boil, and filter; add the rest of water for injection, mix well, filter, fill and seal, and store at 121°C for 15 Minutes autoclave and ready to serve.

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Abstract

The invention discloses injection of mannite and glycerol, which contains mannite, glycerol and water for injection. Furthermore, the invention also discloses a method for preparing the injection, which comprises the following steps: taking the mannite and the glycerol, dissolving into the water for injection, filtering and filling. The injection of the mannite and the glycerol is clinically used for treating cerebrovascular diseases, brain trauma, cerebral tumors, intracranial inflammation and the diseases of acute and chronic intracranial hypertension, hydrocephalus and the like caused by other reasons. The injection of the mannite and the glycerol has the functions of lowering the intracranial pressure quickly and eliminating the hydrocephalus and can also avoid death because of acute renal failure caused by the injury of the kidney; the injection of the mannite and the glycerol suppresses the apoptosis of neural cells and achieves the function of protecting the brain; the function of lowering the intracranial pressure is stable and has long retention time; crystals occurring because of the change of the air temperature or in the processes of storage and transportation are eliminated; and the glycerol is used as a caloric agent and can improve and recover the energy metabolism of the important viscera of the heart, the brain, the kidney and the like during oxygen deficiency. The injection of the mannite and the glycerol is a very effective, stable and safe medicine for promoting urination and removing water clinically.

Description

technical field [0001] The present invention relates to a compound pharmaceutical preparation, especially a kind of mannitol glycerin injection and its preparation method and application Background technique [0002] Intracranial pressure refers to the pressure generated by the contents of the cranial cavity on the wall of the cranial cavity, which is composed of two factors: hydrostatic pressure and vascular dynamic pressure. Since the total volume of the cranial cavity is relatively fixed, the intracranial pressure remains relatively stable. Normal supine intracranial pressure is about 1.33kPa (10mmHg). Intracranial hypertension is called intracranial hypertension when brain tissue swelling; intracranial space-occupying lesions; excessive secretion of cerebrospinal fluid, malabsorption, obstructed circulation, or excessive cerebral blood perfusion lead to intracranial pressure continuously maintained above 2.0kPa (15mmHg). [0003] The clinical manifestations of intracra...

Claims

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Application Information

Patent Timeline
16 Jun 2010
Publication
CN101732287A
IPC
A61K31/047; A61K9/08; A61P7/10; A61P43/00
Inventors
张潞