Polyethylene glycol electrolyte granular preparation and production method

A technology for polyethylene glycol and granule preparations, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. , poor treatment effect and other problems, to achieve good taste, reduce the probability of disadvantages and side effects, and achieve good results

Active Publication Date: 2010-07-07
STAIDSON (BEIJING) BIOPHARMACEUTICALS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the above, the problem to be solved in the present invention is that the quality of the polyethylene glycol electrolyte compound preparation is uncontrollable, and it is cumbersome to take, resulting in poor therapeutic effect and the like.

Method used

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  • Polyethylene glycol electrolyte granular preparation and production method
  • Polyethylene glycol electrolyte granular preparation and production method
  • Polyethylene glycol electrolyte granular preparation and production method

Examples

Experimental program
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Effect test

preparation example 1

[0069] Preparation of Polyethylene Glycol Electrolyte Granules:

[0070] Weigh 13125g of polyethylene glycol 4000 and pulverize it, pass through a 60-mesh sieve to obtain fine particles of polyethylene glycol 4000 with a particle size (D90) of 250 μm. Weigh 178.5g of sodium bicarbonate, 350.7g of sodium chloride, 46.6g of potassium chloride, and 10g of acesulfame potassium, mix them, pulverize them, and pass through an 80-mesh sieve to obtain electrolyte fine particles with a particle size (D90) of 180 μm. After mixing the polyethylene glycol 4000 fine particles obtained above and the electrolyte fine particles uniformly according to the method of equal volume addition, use about 1371 g of 95 volume % ethanol aqueous solution to make a soft material, and then use a 40 mesh sieve to granulate, and the fluidized bed temperature is 10 ° C ~ Boiling and drying at 60° C. for 20 minutes, sizing with a 40-mesh sieve to prepare polyethylene glycol electrolyte particles with a particle...

preparation example 2～ preparation example 6

[0072] According to Table 1, change the composition and dosage of the preparation of polyethylene glycol electrolyte granule preparations, and the type of sieve used, and follow the same operation steps as in Preparation Example 1 to manufacture the polyethylene glycol electrolyte particles of Preparation Examples 2 to 6. Alcohol electrolyte granular preparation.

[0073]

[0074] Hereinafter, the technical effect of the polyethylene glycol electrolyte particle preparation and the manufacturing method thereof of the present invention will be further described through test examples.

[0075] In the present invention, the evaluation method of fluidity (angle of repose) is as follows.

[0076]

[0077] Take the sample particles and flow them into a circular watch glass from a fixed small funnel until the highest cone is obtained. Measure the height H and radius R of the cone, and calculate the angle of repose α according to the following formula. The larger the angle of rep...

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Abstract

The invention provides a polyethylene glycol electrolyte granular preparation and a production method. The polyethylene glycol electrolyte granular preparation comprises polyethylene glycol with the average molecular weight of 3000 to 4000 and electrolyte, and the granule diameter of the polyethylene glycol electrolyte granule is 180Mu m to 850Mu m. The invention at least solves the following problems of the prior polyethylene glycol electrolyte granular preparation that: the production cost is high, the mixing of components is not uniform, the weight cannot be controlled, use is complex, the granule diameters of medicinal powder are not uniform, fluidity is not good, and stability is poor.

Description

technical field [0001] The invention relates to a polyethylene glycol electrolyte soluble particle preparation and a manufacturing method thereof. Background technique [0002] The compound preparation of polyethylene glycol and electrolytes is dissolved in water to form an isotonic solution. The combination of polyethylene glycol and water molecules forms a relatively stable hydrogen bond. After entering the intestinal tract, the water in the intestinal contents is not excessively absorbed by the colon. Thereby lubricating the intestinal tract, softening the feces, increasing the volume of intestinal contents, and promoting the recovery of normal physiological movement of the colon. Taking large doses (2-3 liters) of polyethylene glycol electrolyte compound preparations can flush and lavage the intestinal tract. Moreover, the net exchange of water and electrolyte between the preparation and the mucous membrane of the gastrointestinal tract is basically zero during use, so ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/16A61P1/10A61K31/765A61K33/04A61K33/00
CPCA61K31/765A61K33/14A61K47/10A61P1/10
Inventor 谭剑平张洪山蒋立新
Owner STAIDSON (BEIJING) BIOPHARMACEUTICALS CO LTD
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