Preparation method of water-insoluble drug microcapsule

Abstract

The invention relates to a preparation method of a water-insoluble drug microcapsule. The water-insoluble drug microcapsule is a capsule with a multi-layer shell structure, and the wall of the water-insoluble drug microcapsule consists of a water-insoluble drug and a membrane layer formed by alternating deposition of a plurality of layers of polyelectrolyte with opposite charges. The preparation steps are as follows: 1), at first, preparing a soluble template microsphere with the surface thereof absorbed with a plurality of polyelectrolyte membranes; 2) then, removing the soluble template microsphere to prepare a hollow polyelectrolyte capsule; and 3), finally, loading the water-insoluble drug in the hollow polyelectrolyte capsule. The insoluble drug microcapsule prepared in the method has the advantages of uniform size, high drug solubility, controllable drug releasing rate and good dispersibility in various kinds of aqueous solution, and can also be connected with biologically active substances, such as antibodies, antigens, enzymes, proteins or nucleic acid, in order to achieve drug targeting.

Description

technical field

[0001] The invention relates to a method for preparing microcapsules of poorly water-soluble medicines, in particular to a method for preparing microcapsules with multi-layer shell structure and containing medicines with strong fat solubility and weak water solubility. Background technique

[0002] There are serious problems in the application of poorly water-soluble drugs: First, poor water solubility will lead to poor absorption and low bioavailability, especially for oral administration. Second, intravenous administration of drugs with poor water solubility may cause serious adverse reactions such as pulmonary embolism and even respiratory failure, and may also deposit locally, resulting in excessive local drug concentration and side effects. Data in recent years have shown that nearly 40% of candidate compounds with good therapeutic potential that have been screened through high-throughput have terminated further research and development, including formul...