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Preparation method of polymer/inorganic particle composite bone repair porous scaffold

A technology of inorganic particles and porous scaffolds, applied in medical science, prosthesis, etc., can solve problems such as limiting the interaction of inorganic particles, and achieve the effect of repairing application value, high production efficiency, and improving biological activity.

Inactive Publication Date: 2010-08-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the scaffolds prepared by these methods, the inorganic particles are distributed in the polymer matrix, thus limiting the interaction of cells with the bioactive inorganic particles

Method used

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  • Preparation method of polymer/inorganic particle composite bone repair porous scaffold
  • Preparation method of polymer/inorganic particle composite bone repair porous scaffold
  • Preparation method of polymer/inorganic particle composite bone repair porous scaffold

Examples

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Effect test

example 1

[0026] (1) Calcium nitrate and diammonium hydrogen phosphate are dissolved in water respectively, the preparation 400ml concentration is the diammonium hydrogen phosphate aqueous solution of 0.3mol / L and the calcium nitrate aqueous solution that concentration is 0.5mol / L; Add dropwise into calcium nitrate aqueous solution, stir magnetically, adjust the pH value to 10, react in a 60°C water bath for 2 hours, and then age for 24 hours; repeatedly wash with deionized water, freeze-dry to obtain hydroxyapatite nanoparticles, Such as figure 1 shown. It can be seen from the figure that the hydroxyapatite nanoparticles are needle-shaped and about 300 nanometers long.

[0027] (2) adding hydroxyapatite particles to deionized water, preparing a suspension with a concentration of 30 mg / ml, ultrasonically dispersing, and heating to 70° C.; heating the solid paraffin to obtain molten paraffin liquid;

[0028] (3) Add 30ml of molten paraffin liquid to 100ml of hydroxyapatite particle sus...

example 2

[0033] (1) Calcium nitrate and sodium silicate are dissolved in water respectively, the preparation 400ml concentration is the sodium silicate aqueous solution of 0.5mol / L and the calcium nitrate aqueous solution that concentration is 0.5mol / L; The aqueous solution of sodium silicate is added dropwise to In the calcium nitrate aqueous solution, stir magnetically, adjust the pH value to 10, react in a 60°C water bath for 2 hours, and then age for 24 hours; repeatedly wash with deionized water, and freeze-dry to obtain calcium silicate particles;

[0034] (2) adding calcium silicate particles into deionized water, preparing a suspension with a concentration of 40 mg / ml, ultrasonically dispersing, and heating to 70°C; heating the solid paraffin to obtain molten paraffin liquid;

[0035] (3) Add 20ml of molten paraffin liquid to 100ml of calcium silicate particle suspension, stir to obtain a pickering emulsion, cool to room temperature, filter, wash with deionized water, and freeze...

example 3

[0039](1) With the step (1) in example 1, but the aqueous solution of 0.5mol / L calcium nitrate becomes the mixed aqueous solution of the calcium nitrate of 0.45mol / L and the strontium nitrate of 0.05mol / L, prepares strontium doped hydroxyl Apatite particles.

[0040] (2) adding strontium-doped hydroxyapatite particles into deionized water, preparing a suspension with a concentration of 40mg / ml, ultrasonically dispersing, and heating to 70°C; heating the solid paraffin to obtain molten paraffin liquid;

[0041] (3) Add 20ml of molten paraffin liquid to 100ml of strontium-doped hydroxyapatite particle suspension, stir to obtain a pickering emulsion, cool to room temperature, filter, wash with deionized water, and freeze-dry to obtain a surface-coated strontium-doped hydroxyapatite emulsion. Paraffin microspheres of heterohydroxyapatite particles;

[0042] (4) at room temperature, the paraffin microspheres obtained in step (3) are mixed with the dioxane solution of polylactic ac...

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Abstract

The invention discloses a prepration method of a polymer / inorganic particle composite bone repair porous scaffold. The process comprises the following steps: adding inorganic particles into deionized water and preparing suspension of the inorganic particles; adding molten paraffin wax into the suspension, and obtaining pickering emulsion after stirring; cooling the emulsion to room temperature, filtering, and then obtaining paraffin wax microspheres coated with the inorganic particles on the surface; mixing the paraffin wax microspheres with polymer solution, reducing the temperature, leading the polymer solution to carry out phase separation, freeze-drying, further using n-hexane for washing and removing the paraffin wax microspheres, drying and finally obtaining the polymer / inorganic particle composite bone repair porous scaffold. The prepared polymer / inorganic particle composite porous scaffold has high porosity and pore connectivity, and the inorganic particles are distributed on the pore surface of the porous scaffold, thereby having better biological activity; and the scaffold can meet the requirements of bone tissue engineering scaffold materials on pores and pore diameter structure, thereby having great application prospects.

Description

technical field [0001] The invention relates to a preparation method of a polymer / inorganic particle composite porous support for bone repair, in particular to a preparation method for preparing a polymer / inorganic particle composite porous support with paraffin balls coated with inorganic particles as porogens. Background technique [0002] Bone injury and bone defect are common diseases at present, and the traditional treatment method is autologous or allogeneic bone transplantation for bone tissue repair. Autologous bone grafting has a good repair effect, but there are disadvantages of insufficient donors, secondary surgery, and donor site complications. Allogeneic bone grafting has the disadvantages of immunogenicity and the risk of disease transmission. The techniques and methods of tissue engineering and regenerative medicine can grow into living bone tissue through the growth of osteoblasts or the induction and differentiation of stem cells, and be used for bone repai...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/56
Inventor 高长有李丹仝维鋆王玮
Owner ZHEJIANG UNIV