Poly (L-glutamic acid)/polyacrylic acid hydrogel and preparation method thereof

A technology of polyacrylic acid and glutamic acid, applied in the field of hydrogels, can solve the problems of long release time, increased metabolic burden, inappropriateness, etc.

Active Publication Date: 2010-08-11
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experiments have shown that the release time of the drug used as a drug carrier is longer, it takes 24 hours to release 50%, and 80 to 120 hours to release 80%. It is not suitable as a carrier for oral drugs; the caprolactone produced after the degradation of polycaprolactone will increase the metabolic burden in the body

Method used

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  • Poly (L-glutamic acid)/polyacrylic acid hydrogel and preparation method thereof
  • Poly (L-glutamic acid)/polyacrylic acid hydrogel and preparation method thereof
  • Poly (L-glutamic acid)/polyacrylic acid hydrogel and preparation method thereof

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preparation example Construction

[0032] Another embodiment of the present invention discloses a preparation method of poly(L-glutamic acid) / polyacrylic acid hydrogel, including:

[0033] a) Adjust the pH value of the buffer solution of acrylic acid to 8-9 to obtain the first reaction solution;

[0034] b) adding a buffer solution of poly(L-glutamic acid-g-hydroxyethyl methacrylate) to the first reaction solution to obtain a second reaction solution;

[0035] c) adding an initiator to the second reaction solution to obtain a third reaction solution, and heating or irradiating the third reaction solution to obtain a reaction product;

[0036] d). Soak the reaction product in deionized water to obtain poly(L-glutamic acid) / polyacrylic acid hydrogel.

[0037] According to the present invention, the purpose of adjusting the pH value of the buffer solution of acrylic acid to 8-9 is to make the first reaction solution weakly alkaline, because poly(L-glutamic acid-g-hydroxyethyl methacrylate) is insoluble The acidic solution ...

Embodiment 1

[0053] 1. Take 0.005mol of BLG-NCA monomer into a dry round bottom flask, add 300mL of anhydrous dioxane to the round bottom flask, the BLG-NCA monomer will dissolve, add while stirring the solution in the round bottom flask 0.002mol of triethylamine, then the solution was stirred and reacted at room temperature for 72h, and finally the solution was settled with 3000mL ethanol, filtered, washed with ethanol three times, and dried under vacuum at room temperature for 24h to obtain poly(γ-benzyl-L-gu Amino acid ester).

[0054] 2. Take 5g of the poly(γ-benzyl-L-glutamate) prepared in step 1, dissolve it with 50mL of dichloroacetic acid and add 30mL of hydrogen bromide / glacial acetic acid with a mass content of hydrogen bromide of 33% while stirring. Then, the solution was stirred and reacted at 30° C. for 1.5 hours, and finally settled with 500 mL of acetone, filtered, washed with acetone three times, and vacuum dried at room temperature for 24 hours to obtain poly(L-glutamic acid)...

Embodiment 2

[0056] Take 1g of poly(L-glutamic acid) prepared in Example 1 and mix with 0.1g of hydroxyethyl methacrylate monomer, and dissolve in 30mL DMSO, dissolve all the solids to obtain solution a; then add 0.20g of N, N'-cyclohexylcarbodiimide and 0.10g 4-dimethylaminopyridine were dissolved in 1.5mL DMSO to obtain solution b; pour the above solution b into solution a, react at room temperature for 72 hours, and then filter out the resulting precipitate The filtrate was settled with 400 mL of ether, filtered, washed with ether for three times, dried in vacuum at room temperature for 24 hours, and then dried in vacuum at 40° C. for 24 hours to obtain a polymer with the structure of Formula II.

[0057]

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Abstract

The invention provides a poly (L-glutamic acid)/polyacrylic acid hydrogel and preparation method thereof. The hydrogel contains poly (L-glutamic acid-g-hydroxy ethyl acrylate), polyacrylic acid and water. The preparation method includes the following steps: pH value of acrylic acid buffer solution is regulated to be 8-9, so as to obtain a first reaction solution; poly (L-glutamic acid-g-hydroxy ethyl acrylate) buffer solution is added into the first reaction solution, so as to obtain a second reaction solution; initiator is added into the second reaction solution to obtain a third reaction solution, the third reaction solution is subject to heating or irradiation to obtain reaction product; and the reaction product is placed into deionized water to be soaked, thus obtaining the poly (L-glutamic acid)/polyacrylic acid hydrogel. The poly (L-glutamic acid)/polyacrylic acid hydrogel prepared by the preparation method has biodegradability and high pH sensibility and is especially suitable for being used as oral drug release carrier.

Description

Technical field [0001] The invention relates to the field of hydrogels, in particular to a poly(L-glutamic acid) / polyacrylic acid hydrogel and a preparation method thereof. Background technique [0002] Intelligent polymer hydrogel means that when the external environment, such as temperature, pH value, solution ionic strength or electric field strength changes, it can make a physical or chemical response, and its shape, volume, or water absorption performance will change dramatically. A class of polymers. Due to the unique responsiveness of smart gel under environmental stimuli, it has a wide range of applications in the field of biomedical materials. Among them, pH-sensitive hydrogels have attracted much attention due to their close correlation with human physiological conditions, and are widely used in the fields of biomedicine and pharmacy, such as the preparation of temperature-sensitive tissue engineering hydrogels or pH-sensitive targeted drug release Carrier etc. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L77/02C08L33/02C08J3/24
Inventor 庄秀丽高晓晔汤朝晖陈学思
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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