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Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation

A technology of atorvastatin calcium and amlodipine, which is applied in the field of medicine and can solve the problems of a single drug that cannot fully control mild to moderate hypertension

Inactive Publication Date: 2012-02-22
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many antihypertensive drugs on the market, but each has advantages and disadvantages. Most of them are single drugs, which cannot fully control mild to moderate essential hypertension.

Method used

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  • Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation
  • Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation
  • Amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The preparation prescription (1000) of embodiment 1 amlodipine atorvastatin calcium liposome tablet:

[0072] Amlodipine besylate (calculated as amlodipine) 5g

[0073] Atorvastatin calcium (calculated as atorvastatin) 10g

[0074] Soy Phosphatidylglycerol 20g

[0075] Sodium Glycocholate 4g

[0076] Cholesterol 8g

[0077] Starch 38g

[0078] Lactose 30g

[0079] Crospovidone 6g

[0080] Povidone K30 5g

[0081] Magnesium Stearate 1.5g

[0082] making process:

[0083] (1) Dissolve 20g of soybean phosphatidylglycerol, 4g of sodium glycocholate and 8g of cholesterol in 400ml of a mixed solvent of dichloromethane and ether at a volume ratio of 1:5, mix well, and decompress on a rotary film evaporator Remove the mixed solvent to obtain a phospholipid film;

[0084] (2) Add phosphoric acid-disodium hydrogen phosphate buffer solution with a pH value of 6.0, shake and stir to completely hydrate the phospholipid membrane, emulsify at a high speed, and filter through...

Embodiment 2

[0089] The preparation prescription (1000) of embodiment 2 amlodipine atorvastatin calcium liposome tablet:

[0090]Amlodipine besylate (calculated as amlodipine) 5g

[0091] Atorvastatin calcium (calculated as atorvastatin) 80g

[0092] Soy Phosphatidylglycerol 120g

[0093] Sodium Glycocholate 30g

[0094] Cholesterol 40g

[0095] Microcrystalline Cellulose 55g

[0096] Lactose 76g

[0097] Low-substituted hydroxypropyl cellulose 25g

[0098] Hypromellose 4g

[0099] Magnesium Stearate 5g

[0100] Talc powder 15g

[0101] making process:

[0102] (1) Dissolve 120g of soybean phosphatidylglycerol, 30g of sodium glycocholate and 40g of cholesterol in 700ml of a mixed solvent of dichloromethane and ether at a volume ratio of 1:5, mix well, and decompress on a rotary film evaporator Remove the mixed solvent to obtain a phospholipid film;

[0103] (2) Add phosphoric acid-disodium hydrogen phosphate buffer solution with a pH value of 6.0, shake and stir to completely hy...

Embodiment 3

[0109] The preparation prescription (1000) of embodiment 3 amlodipine atorvastatin calcium liposome capsules:

[0110] Amlodipine besylate (calculated as amlodipine) 10g

[0111] Atorvastatin calcium (calculated as atorvastatin) 10g

[0112] Soy Phosphatidylglycerol 150g

[0113] Sodium Glycocholate 30g

[0114] Cholesterol 50g

[0115] Starch 90g

[0116] Carboxymethyl Starch Sodium 15g

[0117] Povidone K30 10g

[0118] Magnesium Stearate 5g

[0119] making process:

[0120] (1) Dissolve 150g of soybean phosphatidylglycerol, 30g of sodium glycocholate and 50g of cholesterol in 800ml of a mixed solvent of dichloromethane and ether at a volume ratio of 1:5, mix well, and decompress on a rotary film evaporator Remove the mixed solvent to obtain a phospholipid film;

[0121] (2) Add citric acid-sodium citrate buffer solution with a pH value of 6.0, shake and stir to completely hydrate the phospholipid membrane, emulsify at a high speed, and filter through a 0.45 μm micr...

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PUM

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Abstract

The invention relates to an amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation which is prepared from amlodipine besylate and atorvastatin calcium medicine compound liposome and other solid preparation auxiliary materials; and the amlodipine besylate and atorvastatin calcium medicine compound liposome is prepared from benzene sulfonic acid amlodipine, atorvastatin calcium, soybean phosphatidyl glycerin, kennedy acute-inflammation sodium and cholesterol. Compared with traditional preparation, the preparation greatly improves the stability and the bioavailability, and has the advantages of stable medicine delivery, small side effect and more significant curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical solid preparation, in particular to an amlodipine atorvastatin calcium pharmaceutical composition liposome solid preparation and a preparation method thereof, which belong to the technical field of medicine. Background technique [0002] With the development of society, people's living standards are getting higher and higher, and more and more people suffer from hypertension. However, hypertension itself is not terrible, and diagnosis and treatment are easy. Complications: In hypertensive patients, due to the continuous increase of arterial pressure, arteriolar sclerosis in the whole body is caused, which affects the blood supply of tissues and organs, causing various serious consequences and becoming a complication of hypertension. [0003] There are many antihypertensive drugs currently on the market, but each has advantages and disadvantages, and most of them are single drugs, which cannot fully control mild...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61K31/40A61K9/127A61P9/12A61P9/10
Inventor 王明
Owner HAINAN MEILAN SMITH KLINE PHARMA