Sensing dielectric film based on molecular imprinting nanospheres as well as preparation method and application thereof

A technology of molecular imprinting and nanospheres, which is applied in the field of sensing, can solve the problems of difficult adjustment of solvent parameters and in-situ polymerization of molecular imprinting systems to form films, etc., and achieve the effect of improving quality controllability and expanding types

Inactive Publication Date: 2010-10-27
NANTONG DOUBLE GREAT TEXTILE +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The purpose of the present invention is to provide a sensing medium film based on molecularly imprinted nanospheres, which solves the difficulty in adjusting the solvent parameters during the in-situ polymerization preparation of the sensing medium film formed based on molecularly imprinted polymers in the prior art, which leads to difficulties in the molecularly imprinted system. In-situ polymerization film formation and other issues

Method used

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  • Sensing dielectric film based on molecular imprinting nanospheres as well as preparation method and application thereof
  • Sensing dielectric film based on molecular imprinting nanospheres as well as preparation method and application thereof
  • Sensing dielectric film based on molecular imprinting nanospheres as well as preparation method and application thereof

Examples

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Embodiment 1

[0038] Example 1 Preparation of Medium Film Based on Chloramphenicol Molecularly Imprinted Nanospheres

[0039] The molecularly imprinted polymer in this example is chloramphenicol imprinted polymer. The film-forming material is polystyrene (PS) toluene solution. The preparation of chloramphenicol imprinted nanospheres is as follows: the template molecule chloramphenicol (0.1527g) and the functional monomer DEAEM (0.189ml) are fully dissolved in 200mL acetonitrile, mixed thoroughly by ultrasound, and then the cross-linking agent ethylene glycol dimethyl Acrylic acid ester (EGDMA) (2.3625ml) and initiator AIBN (20mg), sealed with N2 for 10min, placed on a rotary evaporator and heated at 70°C. After the reaction and polymerization are complete, the solution is settled and centrifuged, placed in an oven at 60 degrees to dry to remove the solvent, and the white polymer is collected and eluted with methanol-acetic acid (8:2, V / V) solution until it is detected in the eluent. If th...

Embodiment 2

[0043] Example 2 Preparation of Diethylstilbestrol-based Diethylstilbestrol Molecularly Imprinted Nanosphere Dielectric Film

[0044] The molecularly imprinted polymer in this example is diethylstilbestrol imprinted polymer. The film-forming material is polystyrene (PS) toluene solution. The preparation of diethylstilbestrol-imprinted nanospheres is as follows: the template molecule diethylstilbestrol (0.1342 g) and the functional monomer acrylamide (AA) (0.1422 g) were fully dissolved in 100 mL of acetonitrile, mixed thoroughly by ultrasound, and then the cross-linking agent ethylene glycol dimethyl Acrylic acid ester (EGDMA) (1.9ml) and initiator AIBN (19mg), sealed with N2 for 10min, placed on a rotary evaporator and heated at 60°C. After the reaction and polymerization are complete, the solution is settled and centrifuged, placed in an oven at 60 degrees to dry to remove the solvent, and the white polymer is collected and eluted with methanol-acetic acid (8:2, V / V) soluti...

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Abstract

The invention discloses a sensing dielectric film based on molecular imprinting nanospheres as well as a preparation method and application thereof. The sensing dielectric film is prepared by the following steps of: (1) synthesizing the molecular imprinting nanospheres as a film formation component raw material through a microemulsion polymerization process or a precipitation polymerization method; and (2) mixing the molecular imprinting nanospheres obtained in the step (1) and an auxiliary film formation material in a film formation solvent, and spin coating and curing on a non-conductive orconductive substrate by utilizing a spin coating method to form the sensing dielectric film based on the molecular imprinting nanospheres. The dielectric film has large selectable range of the variety of the molecular imprinting polymers, and effectively avoids the problem of mismatching of solvents in the processes of imprinting polymerization and film formation.

Description

technical field [0001] The invention belongs to the field of sensing technology, and in particular relates to a sensing medium film based on molecularly imprinted nanospheres and a preparation method and application thereof. Background technique [0002] White light interference reflectance spectroscopy (Reflectometry Interference Spectroscopy, RIfS) technology uses the principle of visible light interference to detect the enrichment of material interface molecules by analyzing the change of interference pattern, which has the advantages of easy to use, label-free and sensitive. The core of RIfS is the sensing medium membrane and the molecules combined on the membrane constitute the Fabry-Perot interference unit. The application of RIfS spectroscopy at home and abroad focuses on environmental protection, clinical testing and research on the biocompatibility of biological materials. The sensitive layer is mainly the sensing medium film of the polymer interference layer such ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L25/06C08L35/02C08L33/26C08L29/04C08J5/18G01N21/45
Inventor 付德刚戎非刘秋明刘冬梅王永向
Owner NANTONG DOUBLE GREAT TEXTILE
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