Agent for promoting vitamin c transporter production

A vitamin and transporter technology, applied in skin care preparations, plant raw materials, food preparation, etc., can solve problems such as use restrictions and side effects

Inactive Publication Date: 2010-12-15
FUAN KERU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since dexamethasone exhibits hormonal action, its use is greatly restricted from the viewpoint of side effects.
In addition, there are no reports on compounds or plants that enhance the expression of SVCT1

Method used

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  • Agent for promoting vitamin c transporter production
  • Agent for promoting vitamin c transporter production
  • Agent for promoting vitamin c transporter production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] (plant extraction)

[0099]Magnolia obovata, Prunus dulcis, Hydrangea macrophylla, Citrus paradise, Ophiopogon jponicus, Hedera helix, Saponiria officinalis, Houttuynia cordata, Matricaria chamomilla, uncalia gambir, Hamamelis virginiana, Morus alba, Oryza sativa, Equisetum arvense Add 12 L (liter) of 90% ethanol solution to 1000 g of dried product, stir at 40° C. for 5 hours, and recover the filtrate with filter paper. This operation was repeated twice, and the filtrate was concentrated under reduced pressure using an evaporator to remove the ethanol solvent. As a result, 120.6 g of magnolia magnolia extract, 150.4 g of almond extract, 170.9 g of sweet tea extract, 127.3 g of grapefruit extract, 115.3 g of Ophiopogon japonicus extract, 204.8 g of ivy extract, and saponaria extract 143.7g, Houttuynia cordata extract 133.9g, chamomile extract 193.2g, palm catechu extract 168.2g, witch hazel extract 112.0g, mulberry root 103.8g, rice bran extract 184.7g, quince extract ...

Embodiment 2

[0101] (Measurement of production-promoting activity of vitamin C transporter (SVCT) in hepatocytes)

[0102] HepG2 cells (manufactured by Dainippon Pharmaceutical Co., Ltd.) derived from human liver cancer were seeded into a 3.5 cm diameter petri dish (manufactured by Farcon) so that it became 5×10 3 The cells were cultured at 37° C. in the presence of 5% carbon dioxide for 3 days in DMEM medium (manufactured by Gibuko) containing 10% inactivated fetal bovine serum (FBS). After 3 days, it was replaced with a new culture medium and used as cells for adding the test substance. As the tested substances, solstice, cholesteryl benzoate, ugaferine, lapiferine, geranyl acetate, nerolidol, dihydrojasmone, carcelyl acetic acid, guaiazulene, dihydroconiferyl alcohol, Stevioside, DL-α-pinene, verbenoside, 1-heptacosanol, 4-hydroxycoumarin, cholic acid, cholesteryl oleate, ashin, and bergamot were purchased from Funakoshi Corporation. The test substance was dissolved in dimethyl sulfox...

Embodiment 3

[0129] (Measurement of production-promoting activity of vitamin C transporter (SVCT) in melanocytes)

[0130] Human normal melanocyte-derived NHEM cells (manufactured by Kraboo) were seeded in a 3.5-cm-diameter petri dish (manufactured by Farcon) so that 5×10 3 The cells were cultured at 37° C. in the presence of 5% carbon dioxide for 8 days in 254S culture medium (manufactured by Kraboo) containing specific additives. Eight days later, the culture medium was replaced with a new one and used as cells for adding the test substance. As the test substance, the plant extracted from Example 1, Magnolia obovata (Magnolia obovata), almond (Prunus duicis), sweet tea (Hydrangea macrophylla), grapefruit (Citrus paradise), Ophiopogon jponicus (Ophiopogon jponicus), Ivy (Hedera helix), Soapwort (Saponiria officinalis), Houttuynia cordata, Matricaria chamomilla, Uncalia gambir, Hamamelis virginiana, Mulberry (Morus alba), Rice bran (Oryza sativa), quince (Equisetum arvense). The test su...

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Abstract

It is intended to provide a substance having an action of promoting vitamin C transporter production. An agent for promoting vitamin C transporter production contains, as an active ingredient, a compound of marrubiin, cholesteryl benzoate, ugaferin, rapiferin, geranyl acetate, nerolidol, dihydrojasmone, carbacryl acetate, guaizulene, dihydroconiferyl alcohol, stevioside, DL-alpha pyrene, verbenalin, 1-heptacosanol, 4-hydroxycoumarin, cholic acid, cholesteryl oleate, fraxin or bergaptol, or an extract of Magnolia obovata, almond, Hydrangea macrophylla, grapefruit, Ophiopogon japonicus, Hedera helix L, Saponaria officinalis L., Houttuynia cordata, chamomile, Uncaria gambir, hamamelis, Morus alba, rice bran or field horsetail.

Description

technical field [0001] The present invention relates to compounds and plants having a vitamin C transporter production-promoting effect. In addition, it relates to a vitamin C absorption-promoting composition using the compound and a plant, a whitening composition or a collagen synthesis-promoting composition containing the vitamin C absorption-promoting composition. Background technique [0002] As a water-soluble antioxidant substance in organisms, vitamin C has excellent antioxidant effects on superoxide anion and other active oxygen species, and prevents the oxidation of lipid components in cells. In addition, by controlling tyrosinase known to be the rate-limiting enzyme for hydroxylation of proline residues in collagen synthesis and melanin synthesis, adjustment of iron transport by vitamin C chelation, and further regulation of oxidation and reduction to participate in various enzymatic reactions. Although it is a multifunctional vitamin C, groundhogs and primates i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/67A61K8/60A61K8/66A61K8/99A61K36/752A23L1/30A23L1/302A61Q19/02A61P3/00A61K31/375A61K31/7048A23L33/15
CPCA61K8/602A61K8/31A61K8/35A61Q19/08A61K8/494A61K8/37A61K8/342A61K8/498A61K8/97A61Q19/02A61K31/375A61K8/34A61K31/365A61K8/9741A61K8/9789A61K8/9794A61P3/00A61P17/00A61P43/00
Inventor 千场智寻相部香宿里充穗樱井哲人山崎奈穗子人见高正
Owner FUAN KERU
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