Method for preparing phosphosilicate based glass

Abstract

The invention belongs to the field of materials, and in particular relates to a method for preparing phosphosilicate based glass. The method takes water, ethanol or mixture of ethanol and water as solvent, and comprises the following steps: phytic acid, ethyl orthosilicate or calcium chloride are mixed to prepare gel precursor sol solution, and gel precursor sol solution is placed until becoming sol; the sol is aged at 60 DEG C, and is baked in an oven to ensure that the solvent is completely volatilized, and is cooled to room temperature; the temperature rises from the room temperature to the temperature of between 300 and 400 DEG C; and the dry gel is sintered at constant temperature of between 300 and 400 DEG C for at least 10 minutes, and is naturally cooled so as to obtain the phosphosilicate based glass. Compared with the conventional phosphorous precursor, the phytic acid serving as the precursor of phosphorous has smaller toxicity, so the biocompatibility of the material is improved, and the phosphosilicate based glass can be prepared in the conditions of low temperature, low toxicity and low cost, and the method can successfully prepare in a larger component range the phosphosilicate based glass with biodegradation speed which can be regulated in a wider range.

Description

technical field [0001] The invention belongs to the field of materials, in particular to a preparation method of phosphosilicate-based glass. Background technique [0002] With the increase of human life expectancy, artificial implant materials are facing new challenges. The life expectancy of more and more patients exceeds the designed service life of artificial implants, and they have to bear the pain of secondary surgery to replace implants. Therefore, it is necessary to design bioactive and biodegradable materials. [0003] In the early 1970s, Professor L.L. Hench of the University of Florida in the United States invented bioactive glass and applied it to the field of biomedicine for the first time, thus creating a new field of research on biomedical materials-bioactive glass and bioactive glass ceramics. As a biomedical material, this kind of material has incomparable advantages over metals, polymer materials and biologically inert materials, and can form a direct chem...

AI Technical Summary

Problems solved by technology

But this kind of bioglass has certain problems, such as the degradation rate is very slow, and it usually takes 1-2 years for complete degradation

The synthesis method used in this kind of bioglass-melt-extraction-cooling reaction temperature is too high to form porous materials, and it is difficult to achieve a high degree of compounding with organic materials to expand functions. Therefore, it is necessary to study new biomaterials and their preparation methods.

[0005] The introduction of phosphorus can usually increase the degradation rate of glass, but the range of biologically active components in phosphosilicate-based glasses prepared by traditional methods is relatively narrow, usually limited to low phosphorus content, which limits the improvement of glass degradation rate

When using the sol-gel method to prepare phosphosilicate-based glasses, it is usually found that the common precursors of phosphorus (such as phosphoric acid, triethyl phosphate, etc.) and the common precursors of calcium (such as calcium nitrate) have poor compatibility, which is easy to cause phase separation

In order to achieve effective mixing of phosphorus and calcium precursors, people sometimes have to choose a more toxic solvent (such as ethylene glycol) and reduce the concentration of the precursor, which will consume a lot of energy and time in the process of solvent removal , so that its practical operability is greatly reduced

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