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Hydroxy propyl cellulose graft copolymer, preparation method and application thereof

A technology of hydroxypropyl cellulose and copolymer, which is applied in the field of hydroxypropyl cellulose graft copolymer and its preparation, can solve problems such as not being able to meet environmental protection, and achieve large specific surface area, large biological functionality, and diameter thickness uniform effect

Inactive Publication Date: 2010-12-22
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the viscose spinning used in the past can no longer meet the needs of environmental protection and cost reduction, so many new spinning methods have been proposed.

Method used

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  • Hydroxy propyl cellulose graft copolymer, preparation method and application thereof
  • Hydroxy propyl cellulose graft copolymer, preparation method and application thereof
  • Hydroxy propyl cellulose graft copolymer, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1) Preparation of HPC-g-PMPC

[0045]In a 100ml single-necked bottle, add 50ml of twice distilled water and 0.5g of hydroxypropyl cellulose (purchased from Aldrich, USA, Mn=10 000, Mw=80 000), after fully dissolving, add 1ml of 0.5mol / L Cerium ammonium nitrate solution and nitric acid solution, nitrogen bubbling for 30 minutes, add 0.3g 2-methacryloyloxyethyl phosphorylcholine (purchased from Nanjing Letianran Science and Technology Development Institute), after sealing, place in a 30°C water bath After reacting for 3 hours, air was introduced to terminate the reaction, the reaction solution was put into a dialysis bag, and dialyzed in secondary water for 5 days to obtain a clear and transparent solution, which was freeze-dried to obtain the product with a yield of 60%, H 1 In the formula I detected by NMR, m=30, n=0.20.

[0046] 2) Electrospinning

[0047] Dissolve 0.4 g of HPC-g-PMPC in 3 ml of methanol, stir evenly, and let stand to defoam to obtain HPC-g-PMPC spin...

Embodiment 2

[0049] 1) Preparation of HPC-g-PMPC

[0050] In a 100ml single-necked bottle, add 50ml of twice distilled water and 0.5g of hydroxypropyl cellulose (purchased from Aldrich, USA, Mn=10 000, Mw=80 000), after fully dissolving, add 1ml of 0.5mol / L Cerium ammonium nitrate solution and nitric acid solution, nitrogen gas bubbling for 30 minutes, 0.3g of 2-methacryloyloxyethyl phosphorylcholine was added, sealed, placed in a water bath at 30°C for 8 hours, and air was introduced to terminate the reaction. The reaction solution was put into a dialysis bag, and dialyzed in secondary water for 5 days to obtain a clear and transparent solution, which was freeze-dried to obtain the product with a yield of 82%, H 1 In formula I detected by NMR, m=30, n=0.51.

[0051] 2) Electrospinning

[0052] Dissolve 0.4 g of HPC-g-PMPC in 3 ml of methanol, stir evenly, and let stand to defoam to obtain HPC-g-PMPC spinning solution. Use a 10ml disposable syringe to extract the spinning solution, fix ...

Embodiment 3

[0054] 1) Preparation of HPC-g-PMPC

[0055] In a 100ml single-necked bottle, add 50ml double-distilled water and 0.5g hydroxypropyl cellulose (purchased from Aldrich, USA, Mn=100 000, Mw=80 000), after fully dissolving, add 1ml 0.5mol / L Cerium ammonium nitrate solution and nitric acid solution, nitrogen bubbling for 30 minutes, add 0.3g 2-methacryloyloxyethyl phosphorylcholine (purchased from Nanjing Letianran Science and Technology Development Institute), after sealing, place in a 30°C water bath After reacting for 3 hours, air was introduced to terminate the reaction, the reaction solution was put into a dialysis bag, and dialyzed in secondary water for 5 days to obtain a clear and transparent solution, which was freeze-dried to obtain the product with a yield of 65%. h 1 In formula I detected by NMR, m=300, n=0.22.

[0056] 2) Electrospinning

[0057] Dissolve 0.4 g of HPC-g-PMPC in 5 ml of methanol, stir evenly, and let stand for defoaming to obtain HPC-g-PMPC spinning...

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Abstract

The invention discloses a hydroxy propyl cellulose graft copolymer, a preparation method and an application thereof. The method comprises the following steps: in an acid aqueous solution, utilizing cerium salt to trigger hydroxy propyl cellulose to be grated with poly(2-methacryloyloxyethyl phosphorylcholine) (MPC), thereby introducing the MPC with an imitated biomembrane structure into the main chain of the hydroxy propyl cellulose; controlling reaction time to obtain anticoagulant hydroxy propyl cellulose derivatives with different grafting ratios; and utilizing an electrostatic spinning technology and adjusting solvent and relevant spinning condition parameters to obtain nanoscale cellulose fiber. The nanoscale HPC-g-PMPC fiber prepared in the invention has large specific surface area and biological functionality, thereby being capable of being applied to the biological medical fields of preparing anticoagulation non-woven fabrics, tissue engineering support materials, wound clad materials, medicine controlled release films and the like.

Description

technical field [0001] The invention relates to the field of cellulose graft copolymer biomedical materials, in particular to a hydroxypropyl cellulose graft copolymer and its preparation method and application. Background technique [0002] Hydroxypropyl cellulose (HPC) is a water-soluble non-ionic cellulose derivative, which is a semi-synthetic high molecular polymer made from natural cellulose through chemical modification. Due to its excellent biocompatibility, it is widely used in biomedical fields such as coating materials, sustained-release materials, thickeners, film-forming materials, suspending agents, gels, tablet disintegrating agents and adhesives . HPC also has thermoplasticity, cementation ability, emulsification ability and foaming ability. Its concentrated solution can form liquid crystal and has good film-forming property. HPC has better resistance to biodegradation due to its full substitution than HEC (hydroxyethyl cellulose). However, HPC is prone to ...

Claims

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Application Information

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IPC IPC(8): C08F251/02D01F2/24A61L27/20A61L15/28
Inventor 刘瑞刚马林李虹黄勇
Owner INST OF CHEM CHINESE ACAD OF SCI
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