PCL-b-PEG-b-PCL carried hydrophobic medicine polymer vesica as well as preparation method and application thereof

A hydrophobic drug, pcl-b-peg-b-pcl technology, applied in the direction of drug combination, pharmaceutical formula, capsule delivery, etc., can solve the problems of unsatisfactory treatment effect, large toxic and side effects, etc., and achieve strong permeability and stability Good performance and prolong cycle time
CN101940792AInactive Publication Date: 2011-01-12INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Publication Date
2011-01-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a PCL-b-PEG-b-PCL carried hydrophobic medicine polymer vesica as well as a preparation method and application thereof. The polymer vesica is manufactured by the following steps of: (1) dissolving amphipathy triblock copolymer and hydrophobic medicine in organic solvent, evaporating to remove the organic solvent to prepare film, blowing and drying; and (2) adding double distilled water and the product in the step (1) in a container, hydrating, evenly mixing through oscillation, performing ultrasonic to form stable emulsion, collecting filtrate and freezing after filtering the film. The vesica has the main advantages of particle medicine carrying systems such as liposome and nanometer; the stability inside and outside the polymer vesica is remarkably superior to the liposome; the film layer is thicker and is beneficial to packaging hydrophobicity medicine; in the preparation process, emulsifier or surface active agent is not needed, thereby overcoming the defect that the a great amount of emulsifier or surface active agent is needed for traditionally preparing a medicine release system and avoiding toxic side effect to the organism caused by using reagent.
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Description

technical field

[0001] The invention relates to an amphiphilic block copolymer drug-loaded polymer vesicle and its preparation method and application Background technique

[0002] Vesicles are supramolecular aggregates formed by the self-assembly of amphiphilic molecules. They are spherical single-chamber or multi-chamber association structures formed by closed bilayers, similar to cell membrane structures. As a drug carrier, vesicles have the characteristics of changing the distribution of drugs in the body, preventing drug degradation and inactivation, prolonging the action time of drugs, and reducing the toxicity and side effects of drugs. Compared with micelles, vesicles have the following characteristics: (1) vesicles have a large specific surface area and can absorb more reactants than micelles; (2) vesicle membranes composed of bilayer amphiphilic molecules That is, the bilayer membrane of the vesicle has strong rigidity, which can solubilize large drug molecules or ...

Claims

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