Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases

A technology for human placenta and dry eye syndrome, applied in sensory diseases, drug combinations, pharmaceutical formulas, etc., can solve problems that are difficult to cure, have low curative effect, affect people's vision and quality of life, etc.

Inactive Publication Date: 2011-01-19
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dry eye, also known as dry eye syndrome, is a common chronic ophthalmic disease that can lead to erosion and inflammation of the conjunctiva and corneal epithelium. It is difficult to treat and is difficult to cure, seriously affecting people's vision and quality of life
Topical application of artificial tears and growth factors is the main method for the treatment of dry eye. Commonly used eye drops are: sodium hyaluronate eye drops, hydroxypropyl methylcellu

Method used

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  • Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases
  • Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases
  • Applications of human placenta peptide in preparing drugs for treating dry eye syndrome and other ocular surface diseases

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0071] 1. Preparation of human placental peptide stock solution:

[0072] Select healthy maternal placenta that is negative for HIV, hepatitis B virus, hepatitis C virus, and syphilis in prenatal serological tests. The placenta of pregnant women suffering from infectious hepatitis, AIDS, syphilis and other diseases, as well as the placenta of artificial abortion, stillbirth, and various deformities, are not used. The placenta is immediately brought back on ice under aseptic conditions after delivery. The placenta can also be refrigerated below -10°C. It should also be refrigerated during collection and transportation. If the placenta is frozen below -30°C, it should be 3 Applied within months. Take the placenta cord blood for HIV, hepatitis B virus, hepatitis C virus, syphilis, etc. The placenta with negative results can be selected and used.

[0073] Wash the brought back fresh placenta twice with pre-cooled medical physiological saline on the ultra-clean table according to the ...

Example Embodiment

[0077] Example 1. Preparation of 50% (volume fraction) human placental peptide eye drops

[0078] Human placental peptide stock solution 500ml

[0079] Sodium chloride 4g

[0080] 1mol / L sodium hydroxide appropriate amount

[0081] Add water for injection to 1000ml

[0082] Take 4g of sodium chloride and add appropriate amount of water for injection to dissolve it, stir well, adjust the pH to 7.2±0.2 with 1mol / L sodium hydroxide, then add 500ml of human placental peptide stock solution, and then add water for injection to 1000ml. 0.2μm filter membrane filter sterilization, aseptic packaging, each 0.5ml.

[0083] 2. Preparation of thickening human placental peptide eye drops

Example Embodiment

[0084] Example 2. Preparation of 25% (volume fraction) human placental peptide stock solution + 0.1% (mass fraction) sodium hyaluronate eye drops

[0085] Human placental peptide stock solution 250ml

[0086] Sodium chloride 6.0g

[0087] Sodium Hyaluronate 1g

[0088] 1mol / L sodium hydroxide appropriate amount

[0089] Add water for injection to 1000ml

[0090] Take 6.0g of sodium chloride and add appropriate amount of water for injection and dissolve it, stir well, adjust the pH to 7.2±0.2 with 1mol / L sodium hydroxide, then add 1g of sodium hyaluronate, soak to swell, stir and mix well. Autoclave for 30 minutes, cool, make up to 750ml of sterile water for injection, add 250ml of human placental peptide stock solution under aseptic conditions, mix well, sterile aliquot, 0.5ml each.

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PUM

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Abstract

The invention discloses applications of human placenta peptide in preparing drugs for treating simple keratitis, dry eye syndrome, corneal epithelium erosion, corneal alkali burn, various keratititides, LASIK corneal laser surgery and other ocular surface diseases. The experiment proves that the human placenta peptide can increase the tear liquid secretion amount of a dry eye model of New Zealand white rabbits, promote the repairation of corneal epithelium cell damage, increase the quantity of conjunctiva goblet cells, has no stimulation to eyes, and has therapeutic effect on the dry eye model of the New Zealand white rabbit with obvious curative effect, thus the human placenta peptide can be used for treating the dry eye syndrome, the corneal epithelium erosion, corneal epithelium defect, the corneal alkali burn, keratitis and the LASIK corneal laser surgery and the other ocular surface diseases.

Description

Technical field: [0001] The invention belongs to the field of medicine, and specifically relates to the application of human placental peptides in preparing medicines for treating ocular surface diseases such as dry eye, corneal epithelial erosion, corneal epithelial defects, corneal alkali burns, keratitis, LASIK corneal laser surgery and the like. Background technique: [0002] Dry eye, also known as dry eye, is a common chronic ophthalmological disease that can cause erosion and inflammation of the conjunctiva and corneal epithelium. The treatment is difficult and difficult to cure, which seriously affects people's vision and quality of life. Topical application of artificial tears and growth factors is the main method for the treatment of dry eye. Commonly used eye drops are: sodium hyaluronate eye drops, hydroxypropyl methylcellulose eye drops, methyl cellulose eye drops , Polyvinyl alcohol eye drops, polyacrylic acid eye drops, dextran-70 eye drops, epidermal growth factor ...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61K35/50A61P27/02
Inventor 邓新国高杨孙倩娜何梅风李娜
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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