Degradable medical composite conduit containing functional nano coating and preparation method thereof
A nano-coating and functional technology, applied in catheters, other medical devices, etc., can solve the problem of difficult control of drug release rate, degradable catheter degradation rate, etc., to achieve good biodegradability, good tissue compatibility, porosity high rate effect
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Embodiment 1 3
[0038] Example 1 Preparation of three-layer degradable medical composite catheter
[0039] Take 140g polylactic acid (molecular weight is 300,000) and 60g polyglycolic acid (molecular weight is 80,000). Then vacuum-dry at 45° C. for 24 hours, and add a polylactic acid nucleating agent with a total mass of 0.6 g after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material C; at an extrusion temperature of 170°C, a screw speed of 50 rpm and a feed rate of 4.0kg / h Next, the mixed raw material C and 200g polylactic acid (molecular weight: 300,000) are melted and compounded by two medical catheter precision extruders to co-extrude the double-layer composite tube (the mixed raw material C is in the inner layer, and the raw material A is in the middle layer), Clean the surface of the double-layer composite tube, and then fumigate and sterilize it with ethylene peroxide before use; use chloroform as a solvent, make chit...
Embodiment 2 3
[0040] Example 2 Preparation of three-layer degradable medical composite catheter
[0041] Take 140g polylactic acid (molecular weight: 300,000) and 60g polycaprolactone (molecular weight: 80,000). Then vacuum-dry at 45° C. for 24 hours, and add a polylactic acid nucleating agent with a total mass of 0.6 g after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material C; at an extrusion temperature of 170°C, a screw speed of 50 rpm and a feed rate of 4.0kg / h Next, the mixed raw material C and 200g polylactic acid (molecular weight: 300,000) are melted and compounded by two medical catheter precision extruders to co-extrude the double-layer composite tube (the mixed raw material C is in the inner layer, and the raw material A is in the middle layer), Clean the surface of the double-layer composite tube, and then fumigate and sterilize it with ethylene peroxide before use; use chloroform as a solvent, make chitin in...
Embodiment 3 3
[0042] Example 3 Preparation of three-layer degradable medical composite catheter
[0043] Take 120g polylactic acid (molecular weight: 300,000) and 80g polycaprolactone (molecular weight: 80,000). Then vacuum-dry at 45° C. for 24 hours, and add a polylactic acid nucleating agent with a total mass of 0.6 g after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material C; at an extrusion temperature of 180°C, a screw speed of 50 rpm and a feed rate of 4.0kg / h Next, the mixed raw material C and 200g polylactic acid (molecular weight: 300,000) are melted and compounded by two medical catheter precision extruders to co-extrude the double-layer composite tube (the mixed raw material C is in the inner layer, and the raw material A is in the middle layer), Clean the surface of the double-layer composite tube, and then fumigate and sterilize it with ethylene peroxide before use; use chloroform as a solvent, make chitin in...
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