Novel bioresorbable slide fastener scaffold and use thereof

Abstract

The invention discloses use of a novel bioresorbable slide fastener scaffold as a cardiovascular system scaffold or endoluminal stent for cardiovascular disease or luminal stenosis disease. The invention has the advantages that: the novel bioresorbable slide fastener scaffold has good degradability and biocompatibility, is more suitable for a blood vessel scaffold in paediatrics, and cannot causelate stent thrombosis after being implanted so as to ensure that the patient does not need taking an anti-platelet agent for a long time and the subsequently possible surgical operation cannot be influenced; the novel bioresorbable slide fastener scaffold has strong support force, and can serve as the cardiovascular system scaffold or endoluminal stent to be widely applied to the cardiovascular disease or luminal stenosis disease; the novel bioresorbable slide fastener scaffold is easy and convenient to manufacture, is convenient to load medicines and can be used as a carrier of medicines or a vector for gene therapy; the scaffold is equipped with a deliver system to reduce the surgical operating difficulty; and a large number of animal experiments prove that the novel bioresorbable slidefastener scaffold has higher success rate during use, obvious treatment effect and better clinical application prospect.

Description

【Technical field】 [0001] The invention relates to a medical device, in particular to a novel sliding buckle bioabsorbable bracket and its application. 【Background technique】 [0002] Congenital heart disease (hereinafter referred to as congenital heart disease) is the most common cardiovascular disease in childhood, with an incidence rate of 0.678% of live-born babies. Congenital heart disease in infants is accompanied by congenital pulmonary artery and pulmonary vein stenosis, systemic vein and main artery Stenosis of arteries and their branches accounts for 7%-15% of all congenital heart diseases, and right ventricle-pulmonary artery artificial conduit (RV-PA conduit) stenosis after acquired surgery, postoperative restenosis of pulmonary artery and pulmonary vein, systemic vein and aorta The number of patients with restenosis of its branches and stenosis of Fontan's channel will continue to rise with the increase in the surgical capacity of congenital heart disease. [00...

AI Technical Summary

Problems solved by technology

However, the fixed size of the metal stent will not change with the growth of the blood vessel after implantation, and it is easy to cause artificial stenosis due to the mismatch with the size of the blood vessel in the later stage. It is especially not suitable for pediatric vascular stents for children with growth characteristics.

[0005] The metal stent also has the following defects: (1) it is prone to thrombosis and requires long-term antiplatelet therapy; (2) it stays in the human body for life, which affects subsequent possible surgical treatment; (4) It may change the geometric configuration of the blood vessel and block the branches; (5) It hinders the subsequent reconstruction and expansion of the lumen; (6) If the metal stent does not fit tightly with the vessel wall, there will often be small residual gaps after implantation

However, there is no report on the new type of sliding buckle bioabsorbable stent with strong support and easy manufacture and use, and its application as a cardiovascular system stent or luminal stent in cardiovascular or luminal stenosis diseases.

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