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Coptis antidotal powder solid dispersion and preparation method thereof

A technology of solid dispersion and Huanglianjiedu powder, which is applied to medical preparations containing active ingredients, antiviral agents, and pharmaceutical formulas, can solve problems such as difficulties, low drug percentages, and large doses, and achieve increased dispersion and Effects of specific surface area, bioavailability enhancement, and solubility enhancement

Inactive Publication Date: 2011-05-18
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The amount of carrier used in the preparation of solid dispersion is relatively large, and the percentage of drugs is not high (less than 1:1.5), so it is still difficult to apply to larger doses of drugs
Traditional Chinese medicine prescriptions often have large doses, which greatly restricts the application of solid dispersion technology in the field of traditional Chinese medicine. It is urgent to have a new type of carrier that has a large drug load and can promote the stability of solid dispersions.

Method used

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  • Coptis antidotal powder solid dispersion and preparation method thereof
  • Coptis antidotal powder solid dispersion and preparation method thereof
  • Coptis antidotal powder solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Coptidis jiedu powder solid dispersion, the raw materials used and their mass percentages are:

[0024] Coptis 20%

[0025] Skullcap 15%

[0026] Cork 15%

[0027] Gardenia 10%

[0028] Polyethylene glycol 6000 20%

[0029] Poloxamer 15%

[0030] Glycerin or Propylene Glycol 5%.

[0031] The preparation includes the following steps: (1) Take each raw material in proportion, use the superfine pulverization method to pulverize Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron and Gardenia through a 100-mesh sieve, and mix to obtain superfine powder; (2) Then superfine the superfine powder with 95% (v / v) Soak in ethanol to obtain intermediate product a, the dosage of 95% ethanol is twice the mass of superfine powder; (3) dissolve poloxamer in ethanol and mix with intermediate product a to obtain intermediate product b, the dosage of ethanol 2 times the mass of poloxamer; (4) Dissolve polyethylene glycol 6000 and glycerin at 65°C by heating, then mix wit...

Embodiment 2

[0033] Coptidis jiedu powder solid dispersion, the raw materials used and their mass percentages are:

[0034] Coptis 20%

[0035] Skullcap 15%

[0036] Cork 15%

[0037] Gardenia 10%

[0038] Polyethylene glycol 6000 30%

[0039] Poloxamer 5%

[0040] Glycerin or Propylene Glycol 5%.

[0041] The preparation includes the following steps: (1) taking each raw material in proportion, using the superfine pulverization method to pulverize Coptidis Rhizome, Scutellaria baicalensis, Cortex Phellodendron and Gardenia through a 100-mesh sieve, and mix to obtain superfine powder; (2) superfine powder with 95% ( v / v) soaking in ethanol to obtain intermediate product a, the amount of 95% ethanol is 2.5 times the quality of the superfine powder; (3) dissolving poloxamer in ethanol and mixing with intermediate product a to obtain intermediate product b, the amount of ethanol is 2 times the mass of poloxamer; (4) Dissolve polyethylene glycol 6000 and propylene glycol at 68°C, then mix...

Embodiment 3

[0043] Coptidis jiedu powder solid dispersion, the raw materials used and their mass percentages are:

[0044] Coptis 20%

[0045] Skullcap 15%

[0046] Cork 15%

[0047] Gardenia 10%

[0048] Polyethylene glycol 6000 25%

[0049] Poloxamer 5%

[0050] Glycerin or Propylene Glycol 10%.

[0051] The preparation includes the following steps: (1) taking each raw material in proportion, using the superfine pulverization method to pulverize Coptidis Rhizome, Scutellaria baicalensis, Cortex Phellodendron and Gardenia through a 100-mesh sieve, and mix to obtain superfine powder; (2) superfine powder with 95% ( v / v) Soak in ethanol to obtain intermediate product a, the dosage of 95% ethanol is 3 times of the quality of superfine powder; (3) dissolve poloxamer with ethanol and mix with intermediate product a to obtain intermediate product b, the dosage of ethanol is 2 times the mass of the poloxamer; (4) Heat and dissolve polyethylene glycol 6000 and glycerin at 70°C, then mix it...

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Abstract

The invention belongs to the technical field of livestock and poultry Chinese medicines and in particular relates to a coptis antidotal powder solid dispersion which comprises the following components: coptis, scutellaria, cortex phellodendri, fructus gardenia, polyethylene glycol 6000, poloxamer, glycerol or propylene glycol. In the invention, the coptis antidotal powder solid dispersion is prepared by utilizing an ultramicro pulverizing technology and a solid dispersing technology; a suitable carrier is selected to benefit the leaching of effective components in the coptis antidotal powder solid dispersion; the dispersion degree and the specific surface area of a drug are increased, thereby increasing the solubility and the dissolution speed of the coptis antidotal powder solid dispersion, enhancing the bioavailability of the drug and benefiting the dispensing, drug taking and curative effect playing. The coptis antidotal powder solid dispersion has the effects of clearing heat and detoxifying, purging fire and cooling blood, detoxifying and eliminating pathogen, cooling temperature and stopping diarrhea, resisting bacteria and diminishing inflammation and the like and can be used for treating febrile diseases such as livestock and poultry tri-jiao heat, sores, pyogenic infections and the like caused by virus and bacteria.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a solid dispersion of Coptis chinensis powder and a preparation method thereof. Background technique [0002] Coptidis Jiedu Powder is a compound traditional Chinese medicine composed of Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendri, Gardenia, etc. It has the function of purging fire and detoxifying, and it is clinically used to treat livestock and poultry Sanjiao excessive heat, sore yellow swelling, etc. caused by viruses and bacteria. disease. Coptidis jiedu powder prepared by the conventional method is prepared by pulverizing Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron and Gardeniae and mixing them uniformly. Due to the poor solubility of its active ingredients, this method leads to low bioavailability of Huanglian Jiedu powder. [0003] Solid dispersion technology is a new technology in which solids are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/14A61P31/12A61P31/04A61P29/00A61P17/00
Inventor 李明魁张遂平郭芳茹郭彦磊韩莹王菊萍
Owner 河南亚卫动物药业有限公司
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