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Method for extracting L-arabinose and D-galactose from Arabic gum

A technology of arabinose and gum arabic, applied in chemical instruments and methods, monosaccharides, sugar derivatives, etc., can solve the problems of high production cost, limited production capacity, complicated operation, etc., and achieve excellent product quality, low production cost, and easy operation. easy effect

Inactive Publication Date: 2011-08-10
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the above methods obtain L-arabinose and D-galactose through column chromatography or ion exchange resin separation. These methods are complex in operation, high in production cost, low in yield, and limited in production capacity, and are not suitable for large-scale industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Hydrolysis: Weigh 12g of gum arabic, put it into a 250mL three-necked bottle, add 0.6g of 98% concentrated sulfuric acid, 60mL of water, stir, heat, control the temperature at 90°C, and react for 30 hours. After the reaction is finished, take stoichiometric calcium hydroxide to neutralize to neutral or slightly alkaline. filter. The solution is dehydrated to obtain a crude syrup.

[0031] Etherification: Add 24mL of methanol to a 250mL single-necked bottle filled with crude syrup to disperse evenly. Control the temperature to less than 5°C, stir, add 120mL of acetone, and dropwise add 6.0g of 98% concentrated sulfuric acid. After the dropwise addition, adjust the reaction temperature to 10°C to 15°C, and react for 18 hours. After the reaction, add calcium hydroxide to neutralize to neutral or slightly alkaline, filter, and distill the filtrate. Add 60 mL of methanol aqueous solution (methanol:water=1:3) to the obtained residue (mixed etherified product), dissolve the...

Embodiment 2

[0034] Hydrolysis process is with example 1.

[0035] Etherification: Add 120mL of acetone to a 250mL single-necked bottle with crude syrup, add dropwise 4.56g of 98% concentrated sulfuric acid, and slowly raise the reaction temperature to 17°C after the dropwise addition, and react for 25 hours. Sodium is neutralized to neutral or slightly alkaline, filtered, and the filtrate is distilled. Add 80 mL of methanol water (methanol:water=1:3) to the obtained residue (i.e. mixed etherified product), dissolve the residue, add 90 mL of petroleum ether for extraction three times, combine the organic phases and evaporate the solvent to obtain arabinose etherified product. The aqueous phase was extracted with 70 mL of dichloromethane, and the combined organic phase was evaporated to remove the solvent to obtain galactose ether compound. The obtained arabinose ether compound was recrystallized with n-hexane to obtain 2.32g; the galactose ether compound was recrystallized with petroleum ...

Embodiment 3

[0038] Hydrolysis process is with example 1.

[0039] Etherification: Add 120mL of acetone to a 250mL single-necked bottle filled with crude syrup, add 18.0g of 98% concentrated sulfuric acid dropwise, after the dropwise addition, the reaction temperature slowly rises to 17°C, react for 25 hours, and add sodium carbonate after the reaction Neutralize to neutral or slightly alkaline, filter, and distill the filtrate. Add 40 mL of methanol water (methanol:water = 1:3) to the obtained residue (mixed etherified product), dissolve the residue, add 160 mL of petroleum ether for extraction three times, combine the organic phases and evaporate the solvent to obtain arabinose etherified product. The aqueous phase was extracted with 140 mL of chloroform, and the combined organic phases were evaporated to remove the solvent to obtain a galactose ether compound. The obtained arabinose ether compound was recrystallized with n-hexane to obtain 4.05 g; the galactose ether compound was recry...

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Abstract

The invention discloses a method for extracting L-arabinose and D-galactose from Arabic gum, which comprises the following steps of: (1) performing catalytic hydrolysis on the Arabic gum by using an acid catalyst A1, neutralizing, and evaporating out moisture from the obtained reaction liquid to obtain mixed thick syrup; (2) adding an acid catalyst A2 and ketone compounds into the mixed thick syrup for etherification reaction, and after the reaction is finished, neutralizing, distilling to recover the ketone compounds, dissolving the residue by using a mixture of alcohol compounds and water, and performing extraction treatment to respectively obtain arabinose etherate and galactose etherate; and (3) dehydrating and de-etherizing the obtained arabinose etherate and galactose etherate under the catalysis of an acid catalyst A3, neutralizing, and performing decoloration, drying by distillation and crystallization on the obtained solution to obtain the L-arabinose and the D-galactose. The method has the advantages of simple operation, high quality and yield of products, low production cost, capacity of recycling a solvent, suitability for large-scale industrial production and the like.

Description

(1) Technical field [0001] The invention relates to a new chemical method for extracting L-arabinose and D-galactose from gum arabic. (2) Background technology [0002] L-arabinose is mainly used as a pharmaceutical intermediate for the suppression of obesity, preparation of anti-cancer, anti-viral drugs, and drugs for the prevention and treatment of cardiovascular diseases. It can also be used as a biochemical reagent for the preparation of bacterial culture media and for synthesis spices. D-galactose is mainly used as pharmaceutical intermediates, food additives, biochemical reagents and synthetic spices. [0003] Before the present invention was made, the preparation method of L-arabinose was reported in the following documents. For example: CN1373135A discloses using gum arabic as a raw material, hydrolyzing with inorganic acid, neutralizing with alkali, extracting with alcohol, and separating through two columns to prepare L-arabinose. CN 101100685 discloses a method...

Claims

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Application Information

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IPC IPC(8): C07H3/02C07H1/00
Inventor 李永曙谭成侠梅丽琴
Owner ZHEJIANG UNIV OF TECH
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