Preparation method of ease powder antidepressant extractive

An antidepressant and extract technology, which is applied in the field of preparation of traditional Chinese medicine compound extracts, can solve problems such as difficult industrial production, low solvent safety, and difficult quality control, and achieve controllable quality, easy quality control, and reliable curative effect Effect

Active Publication Date: 2011-08-31
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are various dosage forms such as powders, pills, concentrated pills, granules, etc., these medicines all use medicinal materials as raw materials, are simply processed, have difficulties in quality control, many ineffective ingredients, large dosages, and poor compliance.
[0004] In the early stage, our research group app

Method used

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  • Preparation method of ease powder antidepressant extractive
  • Preparation method of ease powder antidepressant extractive

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0011] Example 1 Preparation of Xiaoyao Powder antidepressant extract of the present invention

[0012] Weigh 150g Bupleuri, 150g Atractylodes macrocephala, 150g Radix Paeoniae Alba, 150g Angelica sinensis, 150g Poria cocos, 75g licorice, 50g mint, and 50g ginger, crush them and mix well, add 6 liters of ethyl acetate, heat and reflux for extraction twice (2 hours each time) , combine the extracts, filter, recover the solvent, concentrate to the extract, and dry in a vacuum oven (60°C) to obtain the extract X 1 .

Example Embodiment

[0025] Example 2 Screening of antidepressant activity of extracts of Xiaoyao powder under different extraction solvents and processes

[0026] 2.1 Drug preparation

[0027] The doses of antidepressant extracts under different extraction processes of Xiaoyao powder were equivalent to 46g of raw medicinal materials / Kg of animals. When used, it was dissolved in 0.5% Tween 80 (w / v) 1% cmc-Na solution.

[0028] 2.2 Experimental method

[0029] Mouse tail suspension test. The experimental animals were dosed continuously for 2 weeks according to the corresponding dose, and the spontaneous activity of the mice within 5 minutes was measured the day before the administration. 1 hour after the last gavage, the autonomous activities of the mice were measured within 5 minutes, and then the tail end of a single mouse (2 cm away from the tail end) was glued to the upper part of the carton with adhesive tape, making it in an upside-down state, with the head 15 cm away from the bottom of th...

Example Embodiment

[0039] Example 3 Xiaoyao Powder Extract X 1 Chemical Composition Analysis

[0040] Using advanced analysis methods such as HPLC, GC-MS and modern separation technology, through computer mass spectrometry database search and comparison with standard spectra, combined with the research basis of the standard product and the chemical components of each single medicinal material in Xiaoyao San compound, the extract X 1Contains the following ingredients: liquiritin, p-cymene, menthol, trans-anethole, camphene, phellandrene, syringene, arbyne, 2,6-bis(1,1-dimethylethane) base)-4-methylphenol, orangerene, caryophyllene oxide, piperonene, pinene, β-caryophyllene, guaiacene, β-cydrene, atractone, ligustilide Z, Ligustilide E, Ethyl Linoleate, Dibutyl-phthalate, Butyl Phthalate, Dibutyl Phthalate, Ethyl Cetanoate, Atractylodes I, Atractylodes II , Atractylodes lactone III, methyl linoleate, palmitic acid, etc.

[0041] Experimental results:

[0042] In the present invention, the Xiao...

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Abstract

The invention provides a preparation method of an ease powder antidepressant extractive, which comprises the steps of: weighing radix bupleuri, angelica sinensis, poria cocos, white paeony root, bighead atractylodes rhizome, radix glycyrrhizae preparata, mentha haplocalyx and ginger according to the weight preparation of the prescription of the ease powder; and reflowing and extracting by adding ethyl acetate, filtering, and drying to obtain the ease powder extractive. Compared with the ease powder compound, the ease powder antidepressant extractive is relatively clear and definite in chemical constituents, stable in technology, controllable in quality, lower in dosage, higher in medicine compliance, and convenient to store and transport. Compared with the patent application 201010110283.7, the ease powder antidepressant extractive is equal in antidepressant activity, simplified in technology, observably short in production cost and time, and green and environment-friendly in the use of dissolvent, and convenient to realize the industrialize most importantly. The analysis shows that the extractive mainly comprises the chemical constituents such as ligustilide, butenolide I, butenolide II, butenolide III, palmitic acid and the like. The preparation method is simple in technology, and is controllable in extractive quantity; and the dissolvent is safe to a human body, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine compound extract, in particular to a preparation method of a Xiaoyao powder antidepressant extract. Background technique [0002] Depression is a common mental illness characterized by high morbidity, relapse and disability. According to the prediction of WHO: by 2020, single depression will become the second most disabling disease, and its harm has attracted more and more attention from the medical and health circles. [0003] Xiaoyao San is a classic prescription with a history of nearly a thousand years of application. Modern clinical and pharmacological studies have confirmed that it has obvious antidepressant effects, and no toxic side effects have been found. Although there are many dosage forms such as powders, pills, concentrated pills, and granules, these medicines all use medicinal materials as raw materials. After simple processing, quality control is difficult...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P25/24
Inventor 周玉枝秦雪梅高晓霞李震宇田俊生张丽增
Owner SHANXI UNIV
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