Compound malic acid Ringer's solution and application thereof

Abstract

The invention provides a compound malic acid Ringer's solution comprising the following components: 0.0150-0.0155mol / L of sodium malate, 0.1-0.11mol / L of sodium chloride, 0.0038-0.0042mol / L of potassium chloride, and 0.0018-0.0022mol / L of calcium chloride, wherein the pH is 7.35-7.45, and the osmotic pressure is 295-300mOsm / Kg. The invention fully explains that the malic acid Ringer's solution can provide corresponding extracellular fluid ion ingredients compared with other crystalloid fluids, can notably improve the functions of the viscera of rats with hemorrhagic shock, can maintain a good and stable hemodynamic level, and is safe and reliable. The synthesis and invention of the compound malic acid Ringer's solution can change the traditional idea that the crystalloid fluids only feed in the extracellular fluid ion ingredients, and bring about new breakthrough and leap of the therapeutic actions of the crystalloid fluids.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a compound ringer's malic acid solution and an application thereof. Background technique [0002] Fluid loss in the body is one of the most common conditions in clinical work. Fluid loss will lead to a decrease in circulating blood volume and, in severe cases, shock. The most important pathophysiological changes in shock are the lack of oxygen energy supply caused by massive fluid loss and the changes in systemic organ function caused by peroxidation reactions, which pose a huge threat to life safety (Adams H A Vogt P M. Circulation therapy for severe burn injuries . Unfallchirurg, 2009, 112: 462-71). For the loss of fluid in the body, the most important method in clinical treatment is to infuse crystalloid fluid to supplement extracellular fluid. The most commonly used crystalloids in clinical practice include physiological saline, Ringer's solution, Ringer's lactate soluti...

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Problems solved by technology

Lactated Ringer's solution contains electrolytes similar to those of extracellular fluid, but the pH is only 6.5, and the osmotic concentration is 273mOsm / L. Patients with injury, cerebral edema and severe liver function impairment should not be used (Huang Wenqi. Expert consensus on fluid therapy during anesthesia surgery (2007). Chinese Journal of Practical Surgery, 2008, 28: 422-6.)

Now the latest crystalloid researched in the world is Bomaili, the compound sodium acetate Ringer’s solution, which was launched by American Baxter Company at the end of last century. This crystalloid has the same pH value, similar ion composition and osmotic pressure as the extracellular fluid. However, the disadvantage of Ringer acetate solution is that it does not contain calcium ions, the metabolism of acetic acid is not complete, and it has the effect of dilating blood vessels, which will interfere with the results of enzyme-linked immunosorbent assays, and the price is relatively expensive, and its clinical application is limited (Santry H P Alam H B.Fluidresuscitation : past, present, and the future. Shock, 2010, 33: 229-41)

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