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Mesoporous silica particle compound carrier with controlled-release function as well as preparation method and application thereof

A technology of mesoporous silica and composite carrier, applied in chemical instruments and methods, silicon compounds, inorganic chemistry, etc., can solve the problems of unstable drying and preparation, and achieve favorable drug loading, low preparation temperature, convenient large-scale The effect of mass production

Inactive Publication Date: 2011-09-28
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Spray drying technology is a drying technology widely used in industry, which has played a great role in the drying and preparation of thermally unstable materials or biological materials, but it has not been applied to the surface modification of slow-release or controlled-release carriers. see the report

Method used

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  • Mesoporous silica particle compound carrier with controlled-release function as well as preparation method and application thereof
  • Mesoporous silica particle compound carrier with controlled-release function as well as preparation method and application thereof
  • Mesoporous silica particle compound carrier with controlled-release function as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 0.15g of SBA-15 solid particles and disperse them into 100mL of water under ultrasonic conditions, then add 0.05mL of a silica colloidal solution with a mass concentration of 40%, and then ultrasonically disperse for half an hour to obtain a uniformly mixed suspension. The uniformly mixed suspension is spray-dried through a spray dryer with a maximum power of 3 kilowatts (produced by Shanghai Shunyi Experimental Equipment Co., Ltd.). The spray drying temperature is controlled at 160-250°C, and the flow rate is controlled at 150-200mL / h. The white powder obtained by drying is the mesoporous silica particle composite carrier, such as figure 1 As shown, the carrier core is short rod-shaped mesoporous silica particles with regular mesoporous pores, and the outer surface of the particles is covered with a thin layer of silica nanoparticles to modify the outer surface and pore openings of the mesoporous silica particles. Control the surface properties of mesoporous silica...

Embodiment 2

[0031] Weigh 0.15g of SBA-15 solid particles and disperse them into 100mL of water, then add 0.1mL of a 40% mass concentration of silica colloidal solution, and ultrasonically disperse for half an hour to obtain a well-mixed suspension, and then mix the well-mixed suspension The spray drying is carried out by a spray dryer with a maximum power of 3 kilowatts. The spray drying temperature is controlled at 160-250℃, and the flow rate is controlled at 150-200mL / h. The white powder obtained by drying is covered with silica nanoparticles. Thin layer of short rod-shaped mesoporous silica composite carrier, such as figure 2 Shown.

Embodiment 3

[0033] Weigh 0.1g of MCM-41 solid particles and disperse them into 50mL of water, then add 0.02mL of a 40% mass concentration of silica colloidal solution, and ultrasonically disperse for half an hour to obtain a well-mixed suspension, and then mix the well-mixed suspension The spray drying is carried out by a spray dryer with a maximum power of 3 kilowatts. The spray drying temperature is controlled at 160-250℃, and the flow rate is controlled at 150-200mL / h. The white powder obtained by drying is covered with silica nanoparticles. Thin layer of spherical mesoporous silica composite carrier, such as image 3 Shown.

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Abstract

The invention discloses a mesoporous silica particle compound carrier with a controlled-release function. The core of the carrier is a spherical or rodlike mesoporous silica particle with a regular mesoporous passage; the external surface of the particle is covered by a silica nano-particle or titanium dioxide nano-particle thin layer; the thickness of the thin layer is 30-150nm and can be specifically controlled by changing the mass ratio of mesoporous particles in a suspending liquid and nano-particles in sol; the preparation method of the mesoporous silica particle compound carrier comprises the following steps of: dispersing a certain amount of silica sol or titanium dioxide sol and rodlike SBA-15 or spherical MCM-41 in water to prepare a suspending liquid, and then carrying out spray drying on the suspending liquid by using a spray dryer, wherein the drying temperature is 160-220 DEG C. The mesoporous silica particle compound carrier prepared by using the preparation method can be used as the controlled-release carrier of a functional object such as an inorganic packing material, an antibacterial agent and the like in fields of rubber plastics and coatings and the carrier of medicine controlled-release formulations in medicine fields and can be applied to the environmental friendliness field for adsorbing harmful substances.

Description

Technical field [0001] The invention relates to a mesoporous silica particle composite carrier with slow-release function. At the same time, the invention also relates to a preparation method and application of the mesoporous silica particle composite carrier. Background technique [0002] Controllable sustained-release agents can achieve long-term and stable administration, greatly reduce the number of patients taking, and improve patient compliance with drugs and therapeutic effects. It is a research hotspot in the field of medicine in recent years, and drug carriers are the key to preparing sustained-release preparations. . Drug carrier refers to a system that can change the way drugs enter the human body and their distribution in the body, control the release rate of drugs, or deliver drugs to targeted organs. Various drug carriers are required to have sustained-release or targeted functions in order to reduce drug degradation and loss, reduce toxic side effects, and improve...

Claims

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Application Information

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IPC IPC(8): C08K9/04C08K9/10C08K7/26C08K3/36C09D7/12A61K47/02B01J20/10B01J20/30C09C1/28C09C3/06
Inventor 李洪亮李玲傅爱萍刘慧赵修松
Owner QINGDAO UNIV
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