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Absorbable Vascular Stent

A vascular stent and polylactic acid technology, applied in medical science, surgery and other directions, can solve the problems of unfavorable support of blood vessels and low mechanical strength of vascular stent, and achieve the effect of good mechanical strength and good supporting effect.

Inactive Publication Date: 2011-12-21
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The vascular stent is biodegradable and will not cause vascular restenosis, but the mechanical strength of the vascular stent is low, which is not conducive to supporting the blood vessel during the healing period

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0063] The L-polylactic acid with an intrinsic viscosity of 2.5dL / g and the D-polylactic acid with an intrinsic viscosity of 2.3dL / g were mixed in a banbury mixer at the ratio of 90:10, 70:30, and 50:50, Banburying at 200°C for 5 minutes to obtain a polylactic acid stereocomplex;

[0064] The melting point of the polylactic acid stereocomplex was tested respectively, and the results showed that the polylactic acid stereocomplex obtained in Example 1 had two melting peaks, and the melting temperatures were 175°C and 209°C respectively; the polylactic acid obtained in Example 2 The stereocomplex has two melting peaks, and the melting temperatures are 176°C and 210°C respectively; the polylactic acid stereocomplex obtained in Example 1 has one melting peak, and the melting temperature is 225°C;

[0065] The polylactic acid stereocomplexes were respectively pressed into 2 mm thick sheets in a flat vulcanizing machine at 200° C. while hot.

Embodiment 4

[0075] Mix L-polylactic acid with an intrinsic viscosity of 2.5dL / g, D-polylactic acid with an intrinsic viscosity of 2.3dL / g, and micron-sized hydroxyapatite in an internal mixer, and banbury at 200°C for 5 minutes to obtain Polylactic acid stereocomplex, wherein the mass ratio of the total amount of L-polylactic acid and D-polylactic acid to hydroxyapatite is 90:10, and the mass ratio of L-polylactic acid and D-polylactic acid is 90:10 ;

[0076] Test the melting point of the polylactic acid stereocomplex, which has two melting peaks, and the melting temperatures are 176°C and 205°C respectively;

[0077] While hot, the polylactic acid stereocomplex was pressed into a sheet with a thickness of 2 mm in a flat vulcanizing machine at 200°C.

[0078] The sheet was crystallized at 120° C. for 1 hour, and the mechanical strength of the sheet was tested. See Table 2 for the results. Table 2 shows the test results of the mechanical strength of the sheets provided in Examples 4-5 an...

Embodiment 5

[0080] Mix L-polylactic acid with an intrinsic viscosity of 2.5dL / g, D-polylactic acid with an intrinsic viscosity of 2.3dL / g, and micron-sized hydroxyapatite in an internal mixer, and banbury at 200°C for 5 minutes to obtain Polylactic acid stereocomplex, wherein the mass ratio of the total amount of L-polylactic acid and D-polylactic acid to hydroxyapatite is 90:10, and the mass ratio of L-polylactic acid and D-polylactic acid is 70:30 ;

[0081] Test the melting point of the polylactic acid stereocomplex, which has two melting peaks, and the melting temperatures are 175°C and 216°C respectively;

[0082] While hot, the polylactic acid stereocomplex was pressed into a sheet with a thickness of 2 mm in a flat vulcanizing machine at 200°C.

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Abstract

The invention provides an absorbable vascular stent, which is made of biodegradable materials, and the biodegradable materials include polylactic acid stereocomplexes, and the polylactic acid stereocomplexes are D-polylactic acid and L-polylactic acid. A mixture of lactic acid, or a polymer of D-polylactic acid and L-polylactic acid, the polylactic acid stereocomplex has at least one melting temperature above 200°C. The polylactic acid stereocomplex has good mechanical strength, biocompatibility and biodegradability, and the stent made by processing it also has good mechanical strength, biocompatibility and biodegradability, and is used for vascular The interventional treatment of obstructive diseases has a good supporting effect, and side effects such as thrombosis and restenosis will not occur. Experiments show that the bending strength of the absorbable vascular stent provided by the present invention can reach more than 140 MPa, and the tensile strength can reach more than 60 MPa.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to an absorbable vascular stent. Background technique [0002] Transcatheter interventional therapy is one of the most commonly used treatment methods for vascular obstructive diseases. It has been widely used clinically due to its advantages of less trauma, quick effect, and low mortality. Vascular stent is a commonly used interventional device for catheter interventional therapy. On the basis of lumen balloon expansion, a vascular stent is placed in the lesion segment to support the stenotic and occluded segment of the vessel, reduce the elastic retraction of the vessel, and maintain the smooth blood flow in the lumen. Some internal stents also have the function of preventing restenosis. [0003] Traditional vascular stents are generally made of metal, such as tantalum, stainless steel, nickel-titanium alloy, etc. Metal vascular stents have good mechanical properties...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/02A61L31/16
Inventor 高战团庄秀丽陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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