Polymer composite micro-bead and preparation method thereof

A technology of polymers and microbeads, which is applied in the direction of microsphere preparation, microcapsule preparation, chemical instruments and methods, etc., can solve the problems that the particle size of droplets cannot be precisely controlled, the internal structure cannot be obtained, and the structure of complex microbeads, etc., to achieve The effect of low equipment requirements, low cost, and simple operation

Inactive Publication Date: 2012-01-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods are simple and easy to implement, but their shortcomings are also obvious
These methods cannot precisely control the particle size of the droplets and have a large particle size distribution, while the polymer droplets have a wider particle size distribution ...

Method used

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  • Polymer composite micro-bead and preparation method thereof
  • Polymer composite micro-bead and preparation method thereof
  • Polymer composite micro-bead and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 2% sodium polystyrene sulfonate aqueous solution and 2% chitosan acetic acid / water solution are used as core layers A and B respectively, 5% polylactic acid / methylene chloride is used as shell layer, and the speed ratio of core layer and shell layer is 1 : 2, the water and shell velocity ratio is 30: 1, the diameter of the microtube is 300 microns, the diameter of the microbeads obtained is 200 microns, the core layer is 80 microns, each microbead contains 3 cores, and the shell layer is solidified by solvent volatilization.

Embodiment 2

[0031] 2% sodium hydroxymethyl cellulose aqueous solution and 2% polyacrylamide aqueous solution are used as core layers A and B respectively, 3% polyethylene / white oil solution is used as shell layer, and the speed ratio of core layer and shell layer is 1:5. The velocity ratio of water and the shell layer is 1:1, the diameter of the microtube is 2 mm, the diameter of the obtained microbead is 1.5 mm, and the core layer is 1 mm. Each microbead contains a core, and the shell layer is solidified by solvent extraction. Different drugs are added to the two core layers respectively to obtain drug sustained-release microbeads.

Embodiment 3

[0033] A 5% polyvinylpyrrolidone ethanol solution and a 4% polyvinyl alcohol aqueous solution are used as core layers A and B respectively, silicone oil is used as a shell layer, and toluene diisocyanate is added to the shell layer as a film-forming agent. The velocity ratio of the core layer and the shell layer is 1:10, the velocity ratio of water and the shell layer is 100:1, the diameter of the microtube is 500 microns, the diameter of the obtained microbeads is 400 microns, the core layer is 150 microns, and each microbead contains 1 nuclear. The core layer has two components, one component is added with ferric oxide powder and the other is added with titanium dioxide powder or water-soluble dye to obtain magnetically responsive chromogenic microspheres.

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Abstract

The invention relates to a polymer composite micro-bead and a preparation method thereof. The micro-bead which is in a core-shell structure comprises 1-3 inner cores and an outer shell. Each inner core is composed of two hemispherical polymer droplets; the outer shell is composed of polymer droplets that are incompatible with the shell; the diameter of each inner core is in a range from 50 microns to 1 millimeter; and the diameter of the outer shell is in a range from 100 microns to 1.5 millimeters. The preparation method comprises the steps of: introducing a shell layer polymer solution and two core layer polymer solutions into a micro-tube to form a micro-sphere; then introducing water into the micro-tube; and finally solidifying the shell layer to obtain the micro-bead. The composite micro-bead disclosed by the invention can be prepared through a multi-level micro-tube reactor; and the diameter and the structure of the micro-bead can be controlled by the structure of the micro-tubereactor and preparation parameters. The composite micro-bead disclosed by the invention can be applied to the fields, such as drug carriers and release, cell transplantation and culture, micro-reactors, display devices and the like. The preparation method disclosed by the invention is simple in operation, less in procedures and low in cost and has low requirements on apparatuses.

Description

technical field [0001] The invention belongs to the field of polymer microbeads and preparation thereof, in particular to a kind of polymer composite microbeads and a preparation method thereof. Background technique [0002] Polymer microbeads are used in high-end and civilian fields such as drug carrier and release, cell culture, polymerization, coatings, and cosmetics. The preparation of polymer microbeads usually adopts thermodynamic or mechanical methods, such as emulsification and phase separation. These methods are simple and easy to implement, but their shortcomings are also obvious. These methods cannot precisely control the particle size of the droplets and have a large particle size distribution, while the polymer droplets have a wider particle size distribution during the preparation process due to their higher viscosity than the solvent; methods such as emulsification and phase separation are usually Only single-phase polymer droplets can be obtained, but micro...

Claims

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Application Information

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IPC IPC(8): A61K47/32B01J13/02A61K47/38A61K47/44B01J19/00A61K9/16
Inventor 俞昊朱树琦马骁朱美芳傅武兴郑阳杨玢
Owner DONGHUA UNIV
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