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Konjak polysaccharide compound soft capsule shell and preparation method thereof

A compound soft capsule and konjac polysaccharide technology, which is applied in capsule delivery, food science, etc., can solve the problems of unfavorable drug digestion and absorption, complex composition of main raw materials, and small range of drug selection, and achieve favorable digestion and absorption, good appearance and shape, The effect of stable performance

Inactive Publication Date: 2013-04-24
SHANDONG INST OF COMMERCE & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method only replaces the production material of the capsule shell, but the composition of the main raw materials is complex, the controlled release effect is not obvious, the range of drug selection is small, and it is not conducive to the digestion and absorption of the drug, and the sealing performance is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The formula is: including the following components by weight: 3 parts of konjac polysaccharide, 6 parts of wheat starch, 8 parts of κ-carrageenan, 0.6 parts of xanthan gum, 32 parts of expanding agent (modified pregelatinized starch: guar Soybean gum: gum arabic is 1.3:1.7:1.5), other additives 1.5 parts, plasticizer 23 parts (glycerin: propylene glycol is 1.3:1.2).

[0021] The preparation method is as follows:

[0022] (1) Preparation of solid raw materials: Weigh the materials and their component content (by weight) is: 3 parts of konjac polysaccharide, 8 parts of κ-carrageenan, 6 parts of wheat starch, 0.6 parts of xanthan gum, puffed 32 parts of agent, 1.5 parts of other additives (such as coloring agents, flavoring agents, opacifiers, etc.), placed in a dry container, and stirred and mixed evenly for use;

[0023] (2) Preparation of composite sol solution: weigh 23 parts of plasticizer, take 62 parts of purified water (filtered distilled water), place in a mixer, and st...

Embodiment 2

[0038] The formula is: including the following components by weight, 2.5 parts of konjac polysaccharide, 8 parts of wheat starch, 10 parts of κ-carrageenan, 0.3 parts of xanthan gum, and 29 parts of bulking agent (modified pregelatinized starch: guar Soybean gum: gum arabic is 1.5:2.0:1.5), other additives 1.0 part, plasticizer 21 parts (glycerin: propylene glycol 1.5:1.3).

[0039] The preparation method is as follows:

[0040] (1) Preparation of solid raw materials: Weigh the raw materials according to the dosage relationship of the formula, 2.5 parts of konjac polysaccharide, 10 parts of κ-carrageenan, 8 parts of wheat starch, 0.3 part of xanthan gum, 29 parts of bulking agent, 1.0 part of other additives, Put it in a dry container and mix it evenly for later use;

[0041] (2) Preparation of composite sol solution: weigh 21 parts of plasticizer, take 68 parts of purified water (filtered distilled water), place in a mixer, stir at a speed of 65.0r / min at 58℃ for 20.0min, Then slo...

Embodiment 3

[0046] The formula is: including the following components by weight, 5.3 parts of konjac polysaccharide, 3 parts of wheat starch, 6 parts of κ-carrageenan, 0.6 parts of xanthan gum, 21 parts of expanding agent (modified pregelatinized starch: guar Soybean gum: gum arabic is 1.7:1.9:1.5), 0.7 parts of other additives, 21 parts of plasticizer (glycerin: propylene glycol is 1.5:1.2).

[0047] The preparation method is as follows:

[0048] (1) Preparation of solid raw materials: Weigh the raw materials according to the dosage of the formula, 5.3 parts of konjac polysaccharide, 6 parts of κ-carrageenan, 3 parts of wheat starch, 0.6 part of xanthan gum, 21 parts of expanding agent, and other additives (such as coloring agent) , Flavoring agent, opalescent agent, etc.) is 0.7 parts, placed in a dry container, and stirred and mixed evenly, set aside;

[0049] (2) Preparation of composite sol solution: Weigh 21 parts of plasticizer, take 80 parts of purified water (filtered distilled water),...

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Abstract

The invention relates to a capsule shell and a preparation method thereof, in particular to a konjak polysaccharide compound soft capsule shell and a preparation method thereof. The capsule shell comprises the following components in parts by weight: 0.5-8 parts of konjak polysaccharide, 2-10 parts of wheat starch, 3-15 parts of k-carrageenan, 0.2-4 parts of xanthan gum, 7-45 parts of swelling agent, 6-30 parts of plasticizer and 0.5-3 parts of other additives, wherein the other additives refer to a coloring agent, a preservative, a seasoning agent, a flavoring agent, an opacifying agent, an opalizer and the like. The capsule shell has the advantages of low cost, high moisture retention, long storage time, contribution to digestive absorption of medicaments, reduction in the stimulation of medicaments on the stomach, wide medicament selecting range, stable performance, good appearance, high airtightness and high toughness.

Description

technical field [0001] The invention relates to a capsule shell and a preparation method thereof, in particular to a konjac polysaccharide composite soft capsule shell and a preparation method thereof. Background technique [0002] Capsule shell is an egg-shaped hollow shell used to contain solid powder or granules. It has good bioavailability and can dissolve quickly, reliably and safely. It is the shell for packaging self-made powders, health products, pharmaceuticals, etc. Gelatin is the main raw material for the production of capsule shells. It is collagen obtained by hydrolyzing and concentrating the bones and skin of animals (such as pigs, cattle, sheep, etc.). Currently, most pharmaceutical companies use gelatin as the shell material for soft capsules. However, with the deteriorating global climate and environment, a variety of strange animal diseases have emerged one after another, which undoubtedly has a serious negative impact on the quality and safety of the main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A23L33/00
Inventor 张长峰聂小宝张家国侯成杰王国利
Owner SHANDONG INST OF COMMERCE & TECH
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