Liranaftate and mometasone furoate containing locally applied compound pharmaceutical composition

A technology for topical application of mometasone furoate, applied in the direction of drug combinations, medical preparations containing active ingredients, local antibacterial agents, etc., can solve the problems of obvious, easy to relapse, and ineffective curative effect
CN102379879AActive Publication Date: 2012-03-21南昌百济制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南昌百济制药有限公司
Publication Date
2012-03-21

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Abstract

The invention relates to the technical field of antimycotic medicaments, specifically to a liranaftate and mometasone furoate containing locally applied compound pharmaceutical composition, which contains one or more acceptable auxiliary materials for local application. The invention is characterized in that the weight ratio of liranaftate to mometasone furoate is 1:80-80:1; the balance contains matrix auxiliary materials; The pharmaceutical composition can be emulsifiable paste or ointment, gelata, a solution or an emulsion or a suspension, a coating agent, aerosol or a spraying agent or spray-film, a foaming agent and patch. With the application of the liranaftate and mometasone furoate compound pharmaceutical composition, as mometasone furoate has a vasoconstriction effect, the transdermal absorption rate of liranaftate slows down, local skin tissue concentration of liranaftate is increased, the medicament is minimized to penetrate through the skin into blood, and local skin concentration of the antimycotic medicament is maintained for a longer time.
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Description

[technical field]

[0001] The patent of the present invention relates to the technical field of antifungal drugs, specifically a compound pharmaceutical composition for local application containing liranaftate and mometasone furoate. [Background technique]

[0002] Fungi are usually conditional pathogens for healthy humans, but when the body's resistance is reduced and external factors are unfavorable, they may cause systemic or local fungal infections. Clinically, they are divided into superficial fungal infections and deep fungal infections.

[0003] Superficial fungi mainly refer to dermatophyton, including trichophyton, microsporum and epidermophyton. Skin, hair, deck, the infection that causes is collectively referred to as dermatophytosis (dermatophytosis), abbreviated tinea (tinea), can be divided into several categories such as tinea capitis, tinea corporis, tinea manuum and tinea unguium according to the affected part. Dermatophytosis is the most common superficial ...

Claims

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