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35 results about "Dermatophyton" patented technology
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Dermatophyton is a genus of green algae, in the family Pithophoraceae.
PCR diagnostics of dermatophytes and other pathogenic fungi
InactiveUS20100311041A1Sugar derivativesMicrobiological testing/measurementFungal microorganismsSkin specimen
Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.
Owner:STATENS SERUM INST
Method for identifying five dermatophytes by utilizing high-resolution melting curve
PendingCN110055347AAvoid cross contaminationEasy to operateMicrobiological testing/measurementMicroorganism based processesFluorescenceBiology
The invention provides a method for identifying five dermatophytes by utilizing a high-resolution melting curve and belongs to the technical field of high-resolution melting curve analysis. The methodadopts a pair of specific primers and is based on real-time fluorescence PCR melting curve to identify trichophyton rubrum, trichophyton digitorum, epidermophyton floccosum, microsporum caninum and Microsporum incurvatum. The sequence of the pair of specific primers is as shown as SEQ ID NO.1-2. The method has the advantages of high sensitivity, good specificity and high detection speed, can be used for identifying dermatophytes on the aspects of clinical diagnosis, environmental monitoring, food safety and the like, and provides a reliable basis for infection treatment, environmental sanitation and food safety monitoring of dermatophytes.
Owner:JINHUA MUNICIPAL CENT HOSPITAL
Use of crataegus pit extract in preparation of medicine for treating mycosis
InactiveCN1502357ANo stimulationNon-toxic, side effectsAntimycoticsUnknown materialsDiseaseSide effect
The present invention discloses crataegus pit extract or its medicinal composition and its application in preparation of medicine for curing or preventing mycetes, specially for resisting dermatomycosis and candidiosis. Said invention uses the crataegus pit as raw material, and adopts the existent technological process including the steps of pyrogenic distillation, purification and others to obtain the crataegus pit distillate oil raw liquor. Said medicine has no any toxic side effects, and its therapeutic effect is obvious.
Owner:铁毅 +2
Primers and kit for fluorescent PCR detection of nine dermatophytes
ActiveCN111206114AStrong specificityHigh sensitivityMicrobiological testing/measurementMicroorganism based processesMicrosporumNucleotide
The invention relates to primers and kit for fluorescent PCR detection of nine dermatophytes, and belongs to the technical field of in-vitro molecular detection of pathogenic microorganisms. The primers include an upstream primer with a nucleotide sequence which is shown in SEQ ID No: 1 and a downstream primer with a nucleotide sequence which is shown in SEQ ID No: 2, wherein the nine dermatophytes include Trichophyton rubrum, Trichophyton mentagrophyte, Trichophyton violaceum, Trichophyton schoenleinii, Epidermophyton floccosum, Trichophyta verruca, Microsporum canis and Microsporum gypsum. The detection is fast, sensitive, specific and repeatable through the primers, and the primers can be applied to early, non-invasive and accurate detection of clinical patients, so that assistance of clinical and effective antifungal therapy is achieved.
Owner:杭州缔蓝生物技术有限公司 +1
Application of Torreya essential oil in the preparation of cosmetics and medicines against dermatophytes
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
Folium artemisiae argyi extract and preparation method and application thereof
ActiveCN113713003AHas inhibitory effectEfficient and significant antibacterial activityAntimycoticsDermatological disorderAntibacterial agentPharmacology
The invention discloses a folium artemisiae argyi extract and a preparation method and application thereof to dermatophyte antibacterial agents, and belongs to the field of technical application of plant source antibacterial agents. The antibacterial agents are folium artemisiae argyi extracts prepared by taking traditional Chinese medicinal materials of folium artemisiae argyi as raw materials through ultrasonic extraction (5-75% ethanol) or ethanol reflux extraction, and have an efficient inhibition effect on dermatophytes such as trichophyton rubrum, trichophyton mentagrophytes and microsporum gypseum. After the folium artemisiae argyi extracts are separated and purified through macroporous adsorption resin, 40-95% ethanol separation components have different degrees of inhibition activity on the dermatophytes, wherein the 95% ethanol separation components are most significant. Meanwhile, the main chemical components in the 95% ethanol separation components are eupatilin, physcion, vitexin, brown cyanidin and the like. The folium artemisiae argyi extract can efficiently inhibit the dermatophytes, has the advantages of safety, high efficiency and low toxic and side effects, and provides a new drug source for prevention and treatment of dermatophyte diseases such as tinea of feet and hands.
Owner:湖北嘉绘生物科技有限公司
Method for determining dermatophytes
The invention relates to methods assessing nucleic acids encoding a dermatophyte extracellular serine / threonine-rich protein (ESTRP gene) in identifying and preferably differentiating between dermatophytes. The invention relates further to corresponding detection kits, in addition to isolated probes and oligonucleotides.
Owner:DEHRM检测公司
Traditional Chinese medicine composition for tinea unguium as well as preparation method and application thereof
ActiveCN104138499AImprove the bactericidal effectEnhance the destructive effectAntimycoticsDermatological disorderDiseaseTinea unguium
The invention discloses a jiumiao jiaxianling traditional Chinese medicine composition which is prepared from the following components in parts by weight: 1-30 parts of golden larch bark, 1-30 parts of common goldenrod, 1-30 parts of fructus cnidii, 1-30 parts of dragon blood, 1-30 parts of rheum officinale, 1-30 parts of golden cypress, 1-15 parts of indigo naturalis, 1-15 parts of dried alum and medical oil, including 0.1g-3 parts of artemisia scoparia oil, 0.1g-3 parts of clove oil, 0.1g-3 parts of zanthoxylum oil and 0.1g-3 parts of artemisia oil. The traditional Chinese medicine composition has the killing effect on dermatophytes, trichophyton rubrum, trichophyton gypseum, epidermophyton floccosum, alpha fungus, molds, saccharomycetes and the like and has the advantages that a patient feel less pain, the effect is good, the disease is not easy to relapse, the bacteria can be thoroughly killed, and the small toxic or side effect is caused.
Owner:邓圣平 +2
Compound clobetasol propionate nano-medicament and preparation method thereof
InactiveCN102327273ASystem stabilityOrganic active ingredientsAntimycoticsPropanoic acidEczematous rash
Owner:NORTHWEST A & F UNIV
Artemisia apiacea pet shampoo formula and production process thereof
PendingCN113749989AHas antibacterial propertiesDisinfectantAntibacterial agentsCosmetic preparationsBiotechnologyAmmonium dodecyl sulfate
The invention discloses an artemisia apiacea pet shampoo formula and a production process thereof. The artemisia apiacea pet shampoo formula comprises the following main components in percentage by mass of 0.2 to 0.6 percent of artemisia apiacea oil, 10 to 18 percent of fatty alcohol-polyoxyethylene ether sodium sulfate, 3 to 5 percent of ammonium lauryl sulfate, 2 to 4 percent of an emulsifier, 2 to 4 percent of dodecyl dimethyl betaine, 3 to 5 percent of a thickening agent, 3 to 5 percent of a foam stabilizer, 0.4 to 0.6 percent of pearly concentrate, 0.2 to 0.4 percent of Casson preservatives, 1 to 3 percent of chlorhexidine gluconate and 55 to 65 percent of deionized water. 0.2-1% of artemisia apiacea oil is added into the pet shampoo, when the concentration of the artemisia apiacea oil is 0.25%, the pet shampoo has a bacteriostatic effect on all dermatophytes, when the concentration of the artemisia apiacea oil is 1%, the pet shampoo has a bactericidal effect on all dermatophytes, and the prepared shampoo is cool and mild and has the effects of clearing away heat and toxic materials and killing parasites to relieve itching.
Owner:河南海汇药物研究有限公司
Preparation method of household test strip for rapidly detecting dermatophytes
PendingCN113820484AReduce misdiagnosis and mistreatmentBiological material analysisHome useReagent strip
The invention discloses a preparation method of a household test strip for rapidly detecting dermatophytes. The preparation method is mainly characterized by comprising the following steps: obtaining dermatophytes antigens; preparing a dermatophyte monoclonal antibody; preparing a colloidal gold reagent strip for antigen-antibody reaction; preparing a clinical sample treating fluid; and preparing a complete reagent strip set and an operation instruction. The method adopts the colloidal gold reagent strip to rapidly detect dermatophytes, is suitable for home use or grassroots units, people can check whether they are infected by dermatophytes such as dermatophytosis or onychomycosis by themselves, and then interrogates in internet hospitals or goes to drugstores or purchases antifungal drugs on the internet. The occurrence of misdiagnosis and mistreatment of superficial fungal infection and the economic and time cost of visiting a doctor in a hospital can be effectively reduced.
Owner:HOSPITAL OF DERMATOLOGY CHINESE ACAD OF MEDICAL SCI
Model for simulating dermatophyte infection in vitro and establishment method and application thereof
PendingCN112574943AProne to immune responsePromote infectionCompound screeningFungiMatrigelCell layer
The invention discloses a model for simulating dermatophyte infection in vitro and an establishment method and application thereof, and belongs to the technical field of bioengineering. The model forsimulating dermatophyte infection in vitro comprises matrix glue, an epidermal analogue embedded in the solidified matrix glue and dermatophyte hyphae, the epidermal analogue is of a relatively complete solid sphere structure, and the exterior of the epidermal analogue is a cell layer which is composed of substrate layer cells and substrate upper layer cells and distributed in a surrounding mode,and a keratinization sample non-cell layer is arranged inside; hyphae invade basal layer cells outside the sphere structure and do not invade or only invade a small amount of basal layer cells, and donot invade the keratinization sample non-cell layer inside the sphere structure; the model can effectively simulate the state that dermatophyte infects normal skin tissue, the infection process of the model can be directly observed under a phase contrast microscope, the infection situation can be detected through omics methods such as high-throughput RNA sequencing, and the model can be effectively used for researching the pathogenic mechanism of dermatophyte infection and screening anti-dermatophyte drugs.
Owner:深圳钰捷生物医学科技有限公司
Anti-dermatophytic preparation and use thereof
InactiveUS7291349B2Reduce absorptionSkinBiocideHydroxy compound active ingredientsIn vivoSynergistic combination
The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.
Owner:COUNCIL OF SCI & IND RES
Compound Disaspidin BB and application of compound Disaspidin BB in antibiosis
PendingCN111269105AStrong antifungalBacteria are strongBiocideOrganic chemistryChemical compoundAntibacterial activity
The invention belongs to the technical field of medicines, and particularly discloses a dryopteris fragrans compound Disaspidin BB and application of the dryopteris fragrans compound Disaspidin BB inthe antibacterial aspect. According to the invention, the phloroglucinol compound Disaspidin BB is separated and prepared from the dryopteris fragrans (L.) Schiott.), and the research results show that the compound has good antibacterial activity, especially has a very good antibacterial effect on dermatophyte and bacteria and is extracted from natural plants and has the characteristics of low toxic and side effects and low possibility of generating drug resistance and provides a new choice and way for developing antibacterial drugs and has a very good application prospect.
Owner:GUANGDONG PHARMA UNIV +1
Compound clobetasol propionate nano-medicament and preparation method thereof
The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.
Owner:NORTHWEST A & F UNIV
PCR diagnostics of dermatophytes and other pathogenic fungi
ActiveUS20140154696A1Microbiological testing/measurementDNA preparationTinea InfectionEpidermophyton floccosum infection
Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.
Owner:STATENS SERUM INST
Compound Disalbaspidin PB and application of compound Disalbaspidin PB in antibiosis
ActiveCN111233647AStrong antifungalBacteria are strongAntibacterial agentsOrganic active ingredientsAntifungalAntibiosis
The invention belongs to the technical field of medicines, and particularly discloses a dryopteris fragrans compound Disalbaspidin PB and an application of the dryopteris fragrans compound Disalbaspidin PB in the antibacterial aspect. According to the invention, the phloroglucinol compound Disalbaspidin PB is separated and prepared from Dryopteris fragrans(L)Schott. The research results show thatthe compound has a good antibacterial effect on dermatophyte and bacteria, is low in side effect and not prone to drug resistance, provides a new choice and approach for development of antifungal andbacterial infection drugs, and has a good application prospect.
Owner:GUANGDONG PHARMA UNIV +1
Application of polyphyllin in preparation of anti-candida albicans fluconazole drug-resistant strain product and anti-dermatophyte product
PendingCN114432326ADelay drug resistanceLess irritatingOrganic active ingredientsAntimycoticsBiotechnologyAntifungal drug
The invention relates to the technical field of microbial antibiosis, and provides application of polyphyllin in preparation of a product for resisting a candida albicans fluconazole drug-resistant strain and a product for resisting dermatophyte. The polyphyllin has a definite inhibition effect on a candida albicans fluconazole drug-resistant strain, epidermophyton flocculent, microsporum gypsum and trichophyton rubrum, is steroidal saponin, and is greatly different from the currently common azole antifungal drugs such as ketoconazole, fluconazole, itraconazole and the like in structure. The mechanism of the polyphyllin for resisting a candida albicans fluconazole-resistant strain, epidermophyton flocculent, microsporum gypsum or trichophyton rubrum is different from that of azole antifungal drugs, and the polyphyllin is added into the antibacterial product, so that the common antifungal drug-resistant bacteria can be inhibited, the drug resistance and irritation of the preparation are reduced, and the safety of the preparation is improved.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Application of fluorescent whitening agent in fungal infection resistance
ActiveCN114010790AChange permeabilityStrong targetingAntimycoticsAerosol deliveryGel preparationAntimicrobial action
The application of the stilbene fluorescent whitening agent provided by the invention in inhibition of fungal activity has excellent antibacterial activity on dermatophytes, trichophyton rubrum, Microsporum gypseum and other fungi, and also has an antibacterial effect on drug-resistant candida albicans. In addition, the invention provides a fluorescent whitening agent 85 / linalool gel preparation which is stable, wide in temperature application range and free of skin irritation and toxicity. The preparation is used for treating a guinea pig model infected by trichophyton rubrum, occurrence and development of skin tinea can be controlled, the antibacterial treatment effect of the gel preparation is superior to that of a positive drug terbinafine in a treatment cycle, and the gel preparation is a potential stable efficient antifungal drug.
Owner:CHONGQING UNIV OF TECH
Formula of sweet wormwood herb rice crust and preparation method of sweet wormwood herb rice crust
PendingCN114304496AGood antibacterial effectAchieve bactericidal effectFood scienceBiotechnologyHealthy diet
The invention relates to the technical field of healthy diet products, in particular to a formula of sweet wormwood herb rice crust and a making method of the sweet wormwood herb rice crust, and the sweet wormwood herb rice crust comprises the following raw materials in parts by weight: 100-200 parts of wild sweet wormwood herb, 500-1000 parts of clean water, 50-100 parts of preserved meat, 70-90 parts of rice and 70-90 parts of glutinous rice. The wild wormwood has a relatively strong bacteriostatic effect on staphylococcus epidermidis, catarrha coccus, bacillus anthracis and corynebacterium diphtheriae, and also has a certain inhibiting effect on staphylococcus aureus, pseudomonas aeruginosa, shigella dysenteriae, mycobacterium tuberculosis and the like, so that the bactericidal effect on all dermatophytes is achieved; and meanwhile, the artemisinin also has an anti-influenza virus effect.
Owner:王基明
Anti-mite composition and application thereof
InactiveCN112043817AQuick killEfficient killingCosmetic preparationsBiocideBiotechnologyPharmaceutical Substances
The invention relates to an anti-mite composition and application thereof, and belongs to the technical field of medicine and health. The anti-mite composition is mainly prepared from the following components in parts by weight: 1 to 10 parts of antibacterial peptide, 1 to 10 parts of flos caryophylli extract and 1 to 10 parts of artemisia annua extract. The anti-mite composition provided by the invention is based on the pathogenesis and treatment principle of acariasis, natural active substances such as the antibacterial peptide, the flos caryophylli extract and the artemisia annua extract are selected, and the selected materials are scientific and reasonable in compatibility and have synergistic interaction; the anti-mite composition has the effects of quickly and efficiently killing mites, has a remarkable bacteriostatic or killing effect on dermatophytes, fungi, saccharomycetes, bacteria and the like, and also has excellent anti-inflammatory and itching relieving effects; and the anti-mite composition is natural in source, biodegradable, free of drug residues, unlikely to generate drug resistance, environment-friendly, safe and reliable.
Owner:北京皓尔生物科技有限公司
Application of locust glycolipid in preparing anti-skin ringworm medicament
InactiveCN101199539BSimple processing methodLow costOrganic active ingredientsAntimycoticsDiseaseSide effect
The invention discloses an application of sophorolipids in preparing drugs for resisting dermatophyte, and an application of a combination where the sophorolipids is used as an effective component inpreparing drugs for resisting dermatophyte. With low price, little dosage and remarkable antibacterial effect, the invention has no side effect on the human, and in certain aspects can be used as a drug for replacing conventional antifungal drugs which produce heat resistance easily and drugs for treating skin tinea disease such as corticosteroid with severe side effects. Thus, the invention has great application prospect.
Owner:SHANDONG UNIV
Phthalocyanine-based antifungal agents
A method is described for the photodynamic treatment of a fungal infection in a subject by administering a therapeutically effective amount of a phthalocyanine compound or a pharmaceutically acceptable salt thereof to the subject and activating the phthalocyanine compound with light. The method is useful for treating various dermatophyte infections such as onychomycosis, and in particular fungal infection by Candida and Trichophyton.
Owner:CASE WESTERN RESERVE UNIV
Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives
ActiveUS9637490B2Improve bioavailabilityImprove propertiesBiocideAntimycoticsBenzodiazepineAntifungal
The present invention concerns novel compounds of Formula (I):wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
![Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives](https://images-eureka.patsnap.com/patent_img/be03476d-e488-416c-95e8-2566164c76a2/US09637490-20170502-C00001.png "Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives")
![Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives](https://images-eureka.patsnap.com/patent_img/be03476d-e488-416c-95e8-2566164c76a2/US09637490-20170502-C00002.png "Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives")
![Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives](https://images-eureka.patsnap.com/patent_img/be03476d-e488-416c-95e8-2566164c76a2/US09637490-20170502-C00003.png "Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6<i>H</i>-pyrrolo[1,2-α][1,4]benzodiazepine derivatives")
Owner:JANSSEN PHARMA NV
A traditional Chinese medicine composition for treating tinea manus, pedis and onychomycosis, its preparation method and application
ActiveCN104138499BImprove the bactericidal effectEnhance the destructive effectAntimycoticsDermatological disorderDiseaseEpidermophyton floccosum infection
The invention discloses a jiumiao jiaxianling traditional Chinese medicine composition which is prepared from the following components in parts by weight: 1-30 parts of golden larch bark, 1-30 parts of common goldenrod, 1-30 parts of fructus cnidii, 1-30 parts of dragon blood, 1-30 parts of rheum officinale, 1-30 parts of golden cypress, 1-15 parts of indigo naturalis, 1-15 parts of dried alum and medical oil, including 0.1g-3 parts of artemisia scoparia oil, 0.1g-3 parts of clove oil, 0.1g-3 parts of zanthoxylum oil and 0.1g-3 parts of artemisia oil. The traditional Chinese medicine composition has the killing effect on dermatophytes, trichophyton rubrum, trichophyton gypseum, epidermophyton floccosum, alpha fungus, molds, saccharomycetes and the like and has the advantages that a patient feel less pain, the effect is good, the disease is not easy to relapse, the bacteria can be thoroughly killed, and the small toxic or side effect is caused.
Owner:邓圣平 +2
NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES
ActiveUS20130274250A1Improve bioavailabilityImprove propertiesBiocideAntimycoticsBenzodiazepineAntifungal drug
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I)wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES](https://images-eureka.patsnap.com/patent_img/c3257b85-3ff9-4604-b9c1-ca0afad028d2/US20130274250A1-20131017-C00001.png "NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES")
![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES](https://images-eureka.patsnap.com/patent_img/c3257b85-3ff9-4604-b9c1-ca0afad028d2/US20130274250A1-20131017-C00002.png "NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES")
![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES](https://images-eureka.patsnap.com/patent_img/c3257b85-3ff9-4604-b9c1-ca0afad028d2/US20130274250A1-20131017-C00003.png "NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES")
Owner:JANSSEN PHARMA NV
A kind of mugwort leaf extract and its preparation method and application
ActiveCN113713003BHas inhibitory effectEfficient and significant antibacterial activityAntimycoticsDermatological disorderPharmaceutical SubstancesAntibacterial agent
Owner:湖北嘉绘生物科技有限公司
Non-Heating Detection Method for Dermatophyte
ActiveUS20090226943A1Rapidly and conveniently detectConvenient and rapid and highly accurate detectionMicrobiological testing/measurementDisease diagnosisEnzymeAntibody
The present invention provides a method of detecting dermatophyte, which does not require a complicated operation such as an enzyme treatment and a heat treatment.The present invention provides a method of detecting dermatophyte, including a step of extracting a dermatophyte component from a sample with a treatment liquid containing a non-ionic surfactant or a zwitterionic surfactant, and a kit for diagnosing dermatophyte infection, containing a treatment liquid comprising the above surfactant, and an antibody specifically recognizing a dermatophyte component, which are housed in separate containers.
Owner:JNC CORP
Application of caragana korshinskii extract in preparing medicine for treating and preventing skin tinea
InactiveCN102772477BInhibiting Active IngredientsHigh antibacterial activityAntimycoticsDermatological disorderCaragana korshinskiiPlanting seed
Owner:湖州藏源生物科技有限公司
NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES
ActiveUS20140045827A1Improve bioavailabilityImprove propertiesBiocideAntimycoticsBenzodiazepineAntifungal
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I)wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES](https://images-eureka.patsnap.com/patent_img/c852948b-c632-4f24-b75d-89089c9a5423/US20140045827A1-20140213-C00001.png "NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES")
![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES](https://images-eureka.patsnap.com/patent_img/c852948b-c632-4f24-b75d-89089c9a5423/US20140045827A1-20140213-C00002.png "NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES")
![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES](https://images-eureka.patsnap.com/patent_img/c852948b-c632-4f24-b75d-89089c9a5423/US20140045827A1-20140213-C00003.png "NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES")
Owner:JANSSEN PHARMA NV
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