Preparation method of medical porous metal implant material

A technology of porous materials and metals, applied in the field of preparation of porous niobium implant materials, can solve the problems of reduced biological safety, insufficient purity of finished products, carbon skeleton residues, etc., and achieves improved purity, low viscosity and good biological safety. Effect

Active Publication Date: 2014-08-06
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Preparation method of medical porous metal implant material
  • Preparation method of medical porous metal implant material
  • Preparation method of medical porous metal implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Weigh 8 g of starch and put it into a container with 240 ml of distilled water; place it on an electric stove to heat and stir to make it an aqueous starch solution. Use a 200g balance to weigh 60g of niobium powder with an average particle size of less than 43 microns and an oxygen content of less than 0.1%, add 15ml of cooled starch aqueous solution, stir and mix evenly, and make it into a niobium powder slurry. Use 10×10×30mm porous polyurethane foam (average pore diameter is 0.48mm, density 0.025g / cm 3 , hardness 50°) into it and pour until the pores of the polyurethane foam are filled with niobium powder slurry, then use a clip to take out the polyurethane foam filled with niobium powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 70° C., a drying time of 8 hours, and a vacuum degree of 1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 600°C, holding time 2h. Vacuum...

Embodiment 2

[0033] Example 2: Weigh 5 g of starch and put it into a container with 200 ml of distilled water; place it on an electric stove to heat and stir to make it an aqueous starch solution. Use a 200g balance to weigh 40g of niobium powder with an average particle size of less than 43μm and an oxygen content of less than 0.1%, add 10ml of starch aqueous solution, stir and mix evenly, and make it into a niobium powder slurry. Use 10×10×25mm porous polyurethane foam (average pore diameter is 0.56mm, density 0.030g / cm 3 , hardness 60 0 ) into it and pour until the pores of the polyurethane foam are filled with the niobium powder slurry, then use a clamp to take out the polyurethane foam that has absorbed the niobium powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 80°C for a drying time of 4 hours and maintain a vacuum of 1×10 -2 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 800°C, holding ti...

Embodiment 3

[0036] Example 3: Weigh 6 g of starch and put it into a container with 220 ml of distilled water; place it on an electric stove to heat and stir to make it an aqueous starch solution. Use a 200g balance to weigh 45g of niobium powder with an average particle size of less than 43μm and an oxygen content of less than 0.1%, add 12ml of starch aqueous solution, stir and mix evenly, and make it into a niobium powder slurry. Use 8×8×25mm porous polyurethane foam (average pore size is 0.70mm, density 0.035g / cm 3 , hardness 70°) into it and pour until the pores of the polyurethane foam are filled with niobium powder slurry, then use a clip to take out the polyurethane foam filled with niobium powder slurry and put it into a porcelain plate. Dry in a vacuum drying oven, the drying temperature is 78 ° C, the drying time is 6 hours, and the vacuum degree is kept at 1×10 -1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 700°C, holding time 1.5h. Vacu...

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Abstract

A preparation method of a medical porous metal implant material includes steps of mixing solution, prepared by starch which serves as an organic binder and distilled water which serves as a dispersant, with niobium powder of the average particle size smaller than 43 mu m and oxygen content lower than 0.1% to prepare niobium slurry, pouring the niobium slurry into an organic foam body, impregnating the organic foam body until holes of the organic foam body are filled with the niobium slurry, drying and removing the dispersant, removing the organic binder and the organic foam body in a degreasing manner under the protection atmosphere of inert gas, producing a porous sintered body by vacuum sintering, and finally preparing porous niobium after vacuum annealing and conventional post-treatments, wherein the mass percentage concentration of starch solution ranges from 2% to 6%. The porous niobium of the medical metal implant material, which is prepared by the preparation method, has excellent biological compatibility and safety. Meanwhile, since the porous niobium has the sintered neck structure, mechanical properties such as ductility and the like of the porous niobium are improved, and the preparation method is good and convenient for practical application of the porous niobium in medical metal implanting.

Description

technical field [0001] The invention relates to a method for preparing a porous material for medical metal implantation, in particular to a method for preparing porous niobium as a medical implant material, in particular to a porous niobium implant suitable for biocompatibility and safety The method of preparation of the material. Background technique [0002] Porous medical metal implant materials have important and special purposes such as treating bone tissue trauma and femoral tissue necrosis. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and uniformly distributed, or partially connected and uniformly distributed according to the needs, so that it can be connected with The growth of bone tissue in the human body is consistent, and the weight of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/56B22F3/11
Inventor 阮建明叶雷谢健全节云峰王志强冯华周健
Owner CHONGQING RUNZE PHARM CO LTD
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