Application of oligomeric mannuronic acid to preparation of medicine for resisting influenza A virus subtype H1N1

A mannuronic acid, influenza virus technology, applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of large molecular weight, poor solubility and absorption, limited application, etc. Activity, small molecular weight, good solubility and stability of influenza A H1N1 virus
CN102488697AInactive Publication Date: 2012-06-13OCEAN UNIV OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
OCEAN UNIV OF CHINA
Publication Date
2012-06-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides application of oligomeric mannuronic acid to preparation of a medicine for resisting influenza A virus subtype H1N1. Through experiment, the oligomeric mannuronic acid (OM) has a good function of protecting madin-darby canine kidney cells which are infected by influenza A virus subtype H1N1 in vitro, can effectively reduce virus reproduction, and has an effect equal to thatof a positive control medicine ribavirin. Moreover, OM can also reduce the death of mice which is caused by infection of influenza A virus subtype H1N1 obviously, and prolong the survival time. The oligomeric mannuronic acid (OM) has the advantages of high water solubility and stability, and safety and low toxicity and the like; and in an in vivo-in vitro experiment, the OM can resist influenza Avirus subtype H1N1 well, and the oligomeric mannuronic acid can be expected to be developed to the medicine for resisting influenza A virus.
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Description

technical field

[0001] The invention belongs to the field of marine drugs and relates to the application of oligomannuronic acid in the preparation of drugs against influenza A (H1N1) virus. Background technique

[0002] Influenza A Virus (IAV) belongs to Orthomyxoviridae and has enveloped negative-strand RNA virus, according to the hemagglutinin protein (HA) and neuraminidase protein (NA) on its surface Different structural and genetic characteristics can be divided into several subtypes, such as H1N1, H5N1 and H3N2. IAV has caused at least three large-scale influenza outbreaks in the last century, the worst of which was the Spanish flu outbreak in 1918-1919, which killed more than 40 million people. Since April 2009, the H1N1 subtype influenza A virus originating in Mexico has caused worldwide influenza outbreaks, posing a huge threat to human health. According to the statistics of the World Health Organization, about 600 million people around the world are infected with...

Claims

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