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Multi-trace element injection and preparation method thereof

A technology of trace elements and injections, which is applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of long intravenous infusion time, poor patient compliance, high failure rate of clarity, etc., and achieve good patient compliance and clinical use Convenience, optimize the effect of adding order

Active Publication Date: 2013-11-13
HAISCO PHARMA GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various trace element injection pharmaceutical compositions on the domestic market have problems such as poor product stability, high failure rate of clarity, and darkening of color. Discoloration or precipitation
The specifications of various trace element injection pharmaceutical compositions on the domestic market are 10ml. For clinical use, 10ml of this product needs to be added to 500ml compound amino acid injection or glucose injection, and intravenously dripped for 6-8 hours, and it cannot be mixed with other drugs. Combined use, there are problems such as too long intravenous infusion time, poor patient compliance, difficulty in combined medication, and inability to use in children

Method used

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  • Multi-trace element injection and preparation method thereof
  • Multi-trace element injection and preparation method thereof
  • Multi-trace element injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription

[0028]

[0029]

[0030] (1) Weigh the raw and auxiliary materials according to the prescription amount, stir and dissolve sorbitol, taurine, and glycine with 80% of the prescription amount of water for injection, and add chromium chloride, copper chloride, and chlorine Manganese chloride, zinc chloride, sodium fluoride;

[0031] (2) Add 0.02% activated carbon (W / V) in the solution volume, stir for 15 minutes for adsorption, and circulate decarbonization for 20 minutes;

[0032] (3) Add ferric chloride dissolved in 8ml of 2mol / L hydrochloric acid solution in advance, add sodium selenite, potassium iodide, and sodium molybdate dissolved in 20ml water for injection in sequence, and stir for 15 minutes;

[0033](4) Adjust the pH value to 2.4 with hydrochloric acid solution, add water for injection to the full amount, stir evenly and circulate and filter for 15 minutes;

[0034] (5) After passing the inspection of visible foreign matter and pH value, ...

Embodiment 2

[0036] prescription

[0037]

[0038]

[0039] (1) Weigh the raw and auxiliary materials according to the prescription amount, stir and dissolve sorbitol, taurine, and glycine with 70% of the prescription amount of water for injection, and add chromium chloride, copper chloride, and chlorine Manganese chloride, zinc chloride, sodium fluoride;

[0040] (2) Add 0.02% activated carbon (W / V) in the solution volume, stir for 10 minutes for adsorption, and circulate for 10 minutes for decarbonization;

[0041] (3) Add ferric chloride dissolved in 8ml of 2mol / L hydrochloric acid solution in advance, add sodium selenite, potassium iodide and sodium molybdate dissolved in 20ml water for injection in sequence, and stir for 10min;

[0042] (4) Adjust the pH value to 2.2 with hydrochloric acid solution, add water for injection to the full amount, stir evenly and circulate and filter for 10 minutes;

[0043] (5) After passing the inspection of visible foreign matter and pH value, f...

Embodiment 3

[0045] prescription

[0046]

[0047] (1) Weigh the raw and auxiliary materials according to the prescription amount, stir and dissolve sorbitol, taurine, and glycine with 60% of the prescription amount of water for injection, and add chromium chloride, copper chloride, and chlorine Manganese chloride, zinc chloride, sodium fluoride;

[0048] (2) Add 0.02% activated carbon (W / V) in the solution volume, stir for 20 minutes for adsorption, and circulate for 15 minutes for decarbonization;

[0049] (3) Add ferric chloride dissolved in 8ml of 2mol / L hydrochloric acid solution in advance, add sodium selenite, potassium iodide and sodium molybdate dissolved in 20ml water for injection in sequence, and stir for 15min;

[0050] (4) Adjust the pH value to 2.0 with hydrochloric acid solution, add water for injection to the full amount, stir evenly and circulate and filter for 20 minutes;

[0051] (5) After passing the inspection of visible foreign matter and pH value, fine filter w...

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Abstract

The invention relates to the field of pharmaceutical preparation. To solve the problem in the prior art that a multi-trace element injection is liable to oxidation-reduction reaction to discolor or generate precipitate, the invention discloses a multi-trace element injection, characterized in that a unit dose of the injection contains chromium chloride (CrCl3 6H2O), copper chloride (CuCl2 2H2O), iron chloride (FeCl3 6H2O), manganese chloride (MnCl2 4H2O), sodium molybdate (Na2MoO4 2H2O), sodium selenite (Na2SeO3 5H2O), zinc chloride (ZnCl2), potassium iodide (KI), sodium fluoride (NaF), sorbitol, taurine, glycine and hydrochloric acid. The multi-trace element injection disclosed by the invention has improved stability and clarity and increases the patient compliance.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of various trace element injections and a preparation method thereof. Background technique [0002] Trace elements play an important role in meeting the nutritional needs of the human body, maintaining the normal biochemical reactions of the human body, and maintaining the normal metabolism and physiological functions of the body. When the supply of trace elements is insufficient, the activity of enzymes can be reduced or completely lost, and the synthesis and metabolism of hormones, proteins, vitamins, etc. will be hindered, causing metabolic disorders in the body, and severe cases can be life-threatening. Therefore, trace elements are widely used clinically. [0003] Chinese patent application CN1517085A discloses a pharmaceutical composition of multiple trace element injections, specifically containing 42.6-64.0 μg of chromium chloride, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/34A61K9/08A61P3/02A61K31/045A61K31/19A61K31/198A61K33/00A61K33/04A61K33/16A61K33/18A61K33/24A61K33/26A61K33/30A61K33/32
Inventor 莫毅杨平
Owner HAISCO PHARMA GRP INC