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Xinkangtai orally disintegrating tablet and preparation method thereof

An orally disintegrating tablet, Xinkang technology, applied in the field of orally disintegrating tablets, can solve the problems of unstable curative effect, prone to allergic reactions, damage to the liver, etc., and achieve the effect of moderate hardness, stable content, and small side effects

Inactive Publication Date: 2012-07-04
刘瑶泰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, Danhong Injection is the most researched and clinically used preparation of cardiovascular and cerebrovascular drugs, but it has gradually exposed some problems during its clinical use for many years, such as unstable curative effect, prone to allergic reactions, severe diarrhea, venous Inflammation, liver damage and other adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of Xinkangtai orally disintegrating tablet, by mass, each tablet contains:

[0032] Total saponins of ginseng stems and leaves 20-40mg;

[0033] Danshen extract 70-100mg;

[0034] Safflower extract 20-40mg;

[0035] Microcrystalline cellulose 80mg;

[0036] Croscarmellose 20mg;

[0037] Protein sugar (aspartame) 5mg;

[0038] Sodium carboxymethyl starch 5mg;

[0039] Mannitol 20mg;

[0040] Starch 20-40mg.

[0041] Among them, the effective ingredient Tanshinone II in the Danshen extract -A-- (C-- 19 H 18 O 3 ) The content is 20%.

[0042] The safflower extract is a finished product with the batch number of SFHH111109 from Shaanxi Sunfor Biotechnology Co., Ltd.

[0043] The above-mentioned preparation method of Xinkangtai orally disintegrating tablets includes the following steps in an amount of 300,000 tablets:

[0044] The first step, raw material processing: Weigh the total saponins of ginseng stems and leaves, salvia miltiorrhiza extract, and safflower extract larger than the ...

Embodiment 2

[0052] A kind of Xinkangtai orally disintegrating tablet, by mass, each tablet contains:

[0053] Total saponins of ginseng stems and leaves 20-40mg;

[0054] Danshen extract 70-100mg;

[0055] Safflower extract 20-40mg;

[0056] Tianqi 20-40 mg;

[0057] Microcrystalline cellulose 80mg;

[0058] Croscarmellose 20mg;

[0059] Protein sugar 5mg;

[0060] Sodium carboxymethyl starch 5mg;

[0061] Mannitol 20mg;

[0062] Starch 20-40mg.

[0063] Correspondingly, based on 300,000 tablets, the preparation method of the Xinkangtai orally disintegrating tablet of this embodiment is as follows:

[0064] Step 1: Raw material processing: Weigh the total saponins of ginseng stems and leaves, salvia miltiorrhiza extract, safflower extract, and Tianqi that are larger than the formula amount, crush them through 80 mesh, and then sieve 80 mesh for use;

[0065] Step 2: Weigh the total saponins of ginseng stems and leaves, salvia miltiorrhiza extract, safflower extract, and Tianqi from the spare raw materials;...

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PUM

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Abstract

The invention provides a Xinkangtai orally disintegrating tablet preparation and a preparation method thereof. Each Xinkangtai orally disintegrating tablet comprises 20-40mg of ginseng stem-leave total saponins, 70-100mg of salvia miltiorrhiza extract, 20-40mg of safflower extract, 80mg of microcrystalline cellulose, 20mg of crosslinking carboxymethylcellulose, 5mg of protein sugar, 5mg of carboxymethyl starch sodium, 20mg of mannitol and 20-40mg of starch. The orally disintegrating tablet provided by the invention is smooth in surface, uniform in color and moderate in hardness, and can be disintegrated within 1 minute in an oral cavity; the contents of two major medicines in the preparation are stable, the purity of active ingredients is high, the bioavailability is high, the side effect of the medicine is less, and the prepared product can be used for effectively treating cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris and the like; and on the other hand, the orally disintegrating preparation can be prepared into various dosage forms for doctors and patients to select, thereby meeting the use requirements of different people in different environments.

Description

Technical field [0001] The present invention relates to the technical field of Chinese patent medicines, and in particular to a kind of medicine which has the functions of softening blood vessels, removing blood fat, replenishing vital energy, restoring pulse, strengthening spleen and lung, promoting body fluid, and soothing the nerves. An orally disintegrating tablet for spleen deficiency, lack of food, lung deficiency, asthma and cough, chronic deficiency, palpitations, insomnia, impotence, uterine cold, heart failure and cardiogenic shock and its preparation process. Background technique [0002] At present, the most researched and clinically applied preparation for cardiovascular and cerebrovascular drugs is Danhong injection, but it has gradually exposed some problems during its clinical use for many years, such as unstable efficacy, prone to allergic reactions, severe diarrhea, intravenous Inflammation, liver damage and other adverse reactions. Summary of the invention [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P1/14A61P3/06A61P9/02A61P9/04A61P11/00A61P15/08A61P15/10A61P25/20
Inventor 刘瑶泰
Owner 刘瑶泰