Freezing method for spleen arousing oral liquid medicinal material water extract

A freezing method and oral liquid technology, which can be applied in the directions of pharmaceutical formulations, drug combinations, plant raw materials, etc., can solve the problems of wasting manpower, material resources, and wasting energy, and achieve the effects of energy saving, cost reduction, and stable and uniform product quality.

Inactive Publication Date: 2012-07-04
吉林益民堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of ethanol for precipitation treatment is a waste of manpower, material resources, and energy. Therefore, it is an urgent problem to find a new precipitation method for the water extract of Qipi oral liquid medicinal materials.

Method used

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  • Freezing method for spleen arousing oral liquid medicinal material water extract
  • Freezing method for spleen arousing oral liquid medicinal material water extract
  • Freezing method for spleen arousing oral liquid medicinal material water extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation of Frozen Qipi Oral Liquid Medicinal Material Water Extract

[0019] Weigh 10g of tangerine peel, 20g of Atractylodes macrocephala (stir-fry), 20g of poria cocos, 10g of licorice, 20g of Chinese yam, 20g of lotus seeds (stir-fry), 10g of hawthorn (stir-fry), 16g of Liushenqu (stir-fry), 10g of malt (stir-fry) and Alisma 10g. Combine the dregs and aqueous solution of tangerine peel and Atractylodes atractylodes distillation with Poria cocos, licorice, yam, lotus seeds, hawthorn, Liushenqu, malt and Alisma, add 6 or 5 times the amount of water to decoct twice, the first time for 2 hours, the second time The second time is 1 hour, filter, combine the filtrates, concentrate to a relative density of 1.12-1.20 (85°C), and place it at -20°C for 48 hours (until the solution is completely frozen and placed for more than 24 hours).

[0020] The process of distilling and extracting tangerine peel and Atractylodes macrocephala is as follows: adding 4 times the...

Embodiment 2

[0021] Example 2 Construction of HPLC Fingerprint of Qipi Oral Liquid Medicinal Material Water Extract Liquid Freezing Liquid

[0022] 1. Instruments and reagents

[0023] 1.1 Instrument: Shimadzu LC-2010AHT high performance liquid chromatography (quaternary pump, online degasser, column thermostat (column temperature 28°C), automatic sampler, UVD detector); BS210S electronic balance; chromatographic column: Agilent ZORBAX SB-C 18 (5μm, 4.6×250mm).

[0024] 1.2 Reagent: hesperidin reference substance (purchased from China National Institute of Pharmaceutical and Biological Products). The reagents used for liquid chromatography analysis are chromatographically pure, the rest of the reagents are analytically pure, and the water is ultrapure water.

[0025] 2. High performance liquid chromatography

[0026] 2.1 Preparation of reference substance solution: Accurately weigh an appropriate amount of hesperidin reference substance, accurately weigh it, and add methanol to make a ...

Embodiment 3

[0030] Example 3 Construction of HPLC Standard Fingerprint of Qipi Oral Liquid Medicinal Material Water Extract Freezing Liquid

[0031] Get 8 batches of Qipi Oral Liquid Medicinal Material Water Extract Freezing Liquid, detect by the conditions of Example 1, obtain the HPLC collection of illustrative plates of 8 batches of samples, as figure 2 shown. Through the comparison of 8 batches of HPLC chromatograms, the similarity evaluation system of the HPLC chromatograms was evaluated using the software "Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System" recommended by the Chinese Pharmacopoeia Commission, and the common characteristic peaks were determined to obtain the standard fingerprint of Qipi Oral Liquid.

[0032] In the standard fingerprint spectrum, the fingerprint spectrum of Qipi oral liquid medicinal material water extract frozen solution contains 6 common characteristic peaks, and the reference peak is hesperidin (peak No. 6).

[0033] The re...

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PUM

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Abstract

The invention provides a freezing method for a spleen arousing oral liquid medicinal material water extract. The method comprises the following steps of: combining decoction dregs and an aqueous solution left by distilling and extracting dried orange peel and large-head atractylodes rhizome with indian buead, liquoric root, Chinese yam, lotus seed, fructus crataegi, medicated leaven, malt and oriental waterplantain rhizome; adding water for decocting twice; combining filtrates; concentrating till the relative density is 1.12-1.20 (85 DEG C); and standing at the temperature of 20 DEG C below zero till a solution is fully frozen. According to HPLC (High Performance Liquid Chromatography) analysis, the Chinese medicinal fingerprints of the spleen arousing oral liquid medicinal material waterextract obtained with the method and a spleen arousing oral liquid medicinal material water extract obtained with an alcohol deposition method are completely similar to each other. The method can be used for fully replacing the conventional alcohol deposition process, manpower and materials are saved, saving in energy is facilitated, and stable and uniform quality of a spleen arousing oral liquidmedicinal material water extract product can be ensured.

Description

technical field [0001] The invention relates to a method for freezing the medicinal material water extract of Qipi oral liquid, in particular to a freezing precipitation method for the medicinal material water extract of Qipi oral liquid. Background technique [0002] Qipi Oral Liquid is four types of new drugs (traditional Chinese medicine) produced by Jilin Yimintang Pharmaceutical Co., Ltd., mainly composed of ginseng, fried Atractylodes macrocephala, Poria cocos, licorice, tangerine peel, yam, fried lotus seeds, fried hawthorn, fried Liushenqu, fried Maigan Composed of Bud and Alisma raw materials, according to preclinical pharmacology and toxicology studies, it has the effect of invigorating the spleen and stomach, and is mainly used to treat spleen and stomach weakness, indigestion, abdominal distension and sugar caused by spleen deficiency. [0003] According to the analysis of prescriptions based on TCM theory and experience, the spleen deficiency syndrome of weak sp...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P1/14
Inventor 徐有章徐阳李艳茹丁爱英
Owner 吉林益民堂制药有限公司
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