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Medicament or health-care food composition for preventing or/and treating erythremia

A technology for polycythemia and health food, applied in drug combination, food preparation, extracellular fluid diseases, etc., can solve the problems of not meeting clinical needs, less polycythemia, etc., to improve hypoxia tolerance and relieve physical strength Improvement of fatigue and fatigue symptoms

Inactive Publication Date: 2012-07-04
西藏藏医药大学 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few drugs for the prevention and / or treatment of polycythemia, which cannot meet the clinical needs

Method used

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  • Medicament or health-care food composition for preventing or/and treating erythremia
  • Medicament or health-care food composition for preventing or/and treating erythremia
  • Medicament or health-care food composition for preventing or/and treating erythremia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 The preparation of medicine of the present invention

[0029] Raw materials: Rhodiola daflora 300g, emblica 300g, seabuckthorn 200g, dried ginger 100g

[0030] Excipients: 40g starch, 25g talcum powder, 5g magnesium stearate

[0031] A total of 1000 capsules were made from the above

[0032] Preparation method:

[0033] Add water to decoct the above four flavors three times, add 10 times the amount of water for the first time, add 6 times the amount of water for the second and third times, each time for 3 hours, combine the decoction, and centrifugally filter (3000 rpm), and the filtrate is concentrated to relative Clear paste with a density of 1.05-1.10 (50-60°C), spray-dry to make dry paste powder, add 40g of starch, 25g of talc powder, and 5g of magnesium stearate to the dry paste powder, mix well, make granules, and dry , sieved, put into capsules, and get ready.

Embodiment 2

[0034] Embodiment 2 Drug quality control method of the present invention

[0035] (1) Instruments and reagents

[0036] Instruments: Japan Shimadzu LC-10Avp high performance liquid chromatography, SPD-10AV ultraviolet detector; CBL-100 thermostat. N-2000 chromatographic data workstation (Zhejiang University Zhida Information Co., Ltd.). Shanghai Branson CQ-250 ultrasonic cleaner; BP211D, BP121S electronic balance (German Sartorius company), thin-layer chromatography silica gel G (Qingdao Ocean Chemical Co., Ltd.).

[0037] Reagents: Methanol and tetrahydrofuran are chromatographically pure, and water is redistilled water.

[0038] Reference substance: salidroside was provided by China Institute for the Control of Pharmaceutical and Biological Products (batch number: 110818-200404, for content determination).

[0039] (2) Chromatographic conditions

[0040] Column: Diamonsil TM (Diamond) C 18 250×4.6mm 5μm

[0041] Mobile phase: methanol-tetrahydrofuran-water (5:2:93); ...

Embodiment 3

[0052] Embodiment 3 Determination of the content of gallic acid in the medicine of the present invention

[0053] 1.1. Instruments

[0054] Shimadzu LC-10Avp high performance liquid chromatograph, SPD-10AV UV detector, AT-330 column thermostat;

[0055] N2000 chromatography workstation (Zhejiang University Zhida Information Co., Ltd.);

[0056] BP211D electronic balance (Germany Sartorius company);

[0057] Q-250 ultrasonic cleaner (Shanghai Branson Instrument Manufacturing Co., Ltd.);

[0058] Lambda 35Uv / Vis Spectrometer (Perkin Elmer, USA).

[0059] 1.2. Test drug

[0060] Methanol (chromatographically pure, Fisher Scientific), acetonitrile (chromatographically pure, Fisher Scientific), phosphoric acid (85%, analytically pure, Chengdu Kelong Chemical Reagent Company), and water were deionized pure water.

[0061] Gallic acid (for content determination, China Institute for the Control of Pharmaceutical and Biological Products, 110831-200302).

[0062] The medicine of t...

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PUM

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Abstract

The invention provides a medicament or a health-care food composition for preventing or / and treating erythremia. The medicament or the health-care food composition is prepared from the following bulk pharmaceuticals in parts by weight: 200-400 parts of rhodiola rosea, 200-400 parts of emblic leaf flower fruit, 100-300 parts of sea buckthorn and 50-150 parts of dried ginger. The invention further provides a preparation method and an application of the composition. The medicament is used for preventing or / and treating, has a physical fatigue relieving function, and has a definite action; and a new option is provided for clinical use.

Description

technical field [0001] The invention relates to a medicine or health food composition for preventing or / and treating polycythemia. It belongs to the field of medicine. Background technique [0002] Polycythemia is characterized by significantly higher than normal levels of red blood cell count, hemoglobin, hematocrit, and total blood volume. Hemoglobin exceeds 180g / L (16g / dl), hematocrit is greater than 55% and the absolute value of red blood cell volume exceeds 35ml per kilogram of body weight in childhood, excluding relative erythrocytosis caused by hemoconcentration caused by acute dehydration or burns, etc. can be diagnosed. Polycythemia can be divided into two categories: primary and secondary. Primary is polycythemia vera; secondary is mainly caused by tissue hypoxia. [0003] High altitude polycythemia (referred to as "high redness" high altitude polycythemia or "high altitude plethora") is a clinical type of chronic altitude sickness, which means that the human bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P7/00A61P39/00A23L1/29A23L33/00
Inventor 索朗其美张艺松桂花孟宪丽泽仁达瓦赖先荣伍文彬
Owner 西藏藏医药大学
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