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Pharmaceutical composition containing propofol and opioid analgesics and use thereof

A composition and opioid technology, applied in the field of medicine, can solve problems such as inconvenience in use, and achieve the effects of low water content, reasonable formulation and good reconstitution property

Inactive Publication Date: 2012-08-08
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, opioid analgesics and propofol are administered separately clinically, which is inconvenient to use during surgery

Method used

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  • Pharmaceutical composition containing propofol and opioid analgesics and use thereof
  • Pharmaceutical composition containing propofol and opioid analgesics and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Remifentanil and Propofol Lyophilized Powder for Injection

[0027] Remifentanil 20mg

[0028] Propofol 5g

[0029] Arginine 5.02g

[0030] Add water for injection to 50ml, make 10 tubes in total

[0031] In this embodiment, the specification is that each bottle contains 0.502 g of the composition of remifentanil and propofol.

[0032] Arginine is selected as the backbone support part of the pharmaceutical composition of remifentanil and propofol. Based on literature reports and combined with practical experience in the production of other lyophilized preparations. Tested by simulating actual production, it is determined that the mass ratio of the pharmaceutical composition to arginine is 1:1. Water for injection is used as a solvent for dissolving raw materials, and an appropriate amount is added according to the concentration of the liquid medicine and the loading amount of each medicine. The preparation process of the preparation as follows:

[0033]...

Embodiment 2

[0036] Embodiment 2: Alfentanil and propofol freeze-dried powder for injection

[0037] Alfentanil 20mg

[0038] Propofol 10g

[0039] Histidine 10.02g

[0040] Add water for injection to 50ml, make 10 tubes in total

[0041] In this embodiment, the specification is that each bottle contains 10.02 g of the composition of alfentanil and propofol.

[0042] Histidine is selected as the backbone support part of the pharmaceutical composition of alfentanil and propofol. Based on literature reports and combined with practical experience in the production of other lyophilized preparations. Tests were carried out by simulating actual production, and it was determined that the ratio of the pharmaceutical composition to arginine was 1:1. Water for injection was used as a solvent for dissolving raw materials, and an appropriate amount was added according to the concentration of the liquid medicine and the loading amount of each medicine. The preparation process of the preparation is ...

Embodiment 3

[0046] Example 3: Sufentanil and Propofol Sublingual Tablets

[0047] Sufentanil 20mg

[0048] Propofol 5g

[0049] Mannitol 300g

[0050] Lactose 200g

[0051] Carboxymethyl Starch Sodium 18g

[0052] Citric acid 18g

[0053] Magnesium stearate 1.8g

[0054] Makes 100 pieces

[0055] The raw and auxiliary materials are weighed according to the above-mentioned prescription quantity, passed through a 60-120 mesh sieve, mixed evenly, and pressed into tablets by using a suitable die to obtain the product.

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Abstract

The invention discloses a pharmaceutical composition containing propofol and opioid analgesics and a use thereof. The pharmaceutical composition comprises pharmaceutically acceptable carriers, propofol as a first active component and opioid analgesics as second active components selected from fentanyl, remifentanil, sufentanil and alfentanil. The pharmaceutical composition containing propofol and opioid analgesics utilizes the combination of narcotic analgesics and a narcotic sedative, has effects of analgesia and sedation, reduces the frequency of drug administration carried out by an analgesist, makes an anesthesia induction process more convenient, obviously reduces an incidence rate and the severity of the propofol injection pain, and reduces adverse reactions of monotherapy.

Description

technical field [0001] The invention relates to a compound pharmaceutical preparation, in particular to a compound preparation composed of propofol and an opioid analgesic, and belongs to the technical field of medicine. Background technique [0002] Analgesic and sedative anesthetic drugs are used simultaneously for anesthesia induction in surgery at present. In clinical practice, fentanyl-based narcotic analgesics and anesthetic and sedative drug propofol are often combined. [0003] Opioid analgesics play an important role in pain management, and fentanyl, remifentanil, sufentanil, and alfentanil are commonly used opioid analgesics. Opioids are easily degraded by non-specific esterases in blood and other tissues, so they are quickly cleared in the body and have a short half-life. The elimination speed is not affected by the administration time and dose, and the elimination half-life is short. It has strong analgesic effect, but extremely weak sedative effect, and has lit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4468A61K31/05A61K31/4535A61K31/454A61P29/00A61P25/20
Inventor 熊利泽文爱东贾娜奚苗苗朱艳荣关月郭超王艳华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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