Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition with blood uric acid adjusting function

A composition and blood uric acid technology, applied in the field of medicine, can solve the problems of renal function impact, uric acid rebound, and ineffective effects, etc., and achieve the effect of reducing the impact of renal function, promoting uric acid excretion, and outstanding health care effects

Inactive Publication Date: 2012-09-05
KPC PHARM INC
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, mangiferin is an active ingredient of non-uric acid-excretion-lowering uric acid, and its effect on uric acid excretion is not obvious. Taking mangiferin alone has the problem of rapid rebound of uric acid after short-term use, and long-term use has a certain impact on kidney function.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition with blood uric acid adjusting function
  • Composition with blood uric acid adjusting function
  • Composition with blood uric acid adjusting function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Effect of the mangiferin composition of the present invention on uric acid in normal mice

[0027] 110 male Kunming mice, weighing 18-22 g, were randomly divided into 9 groups, 10 in each group, respectively: normal control group, 4 different dosage groups of mangiferin, and the composition 4 of mangiferin: Poria cocos=1:20 different dosage groups (hereinafter referred to as the mangiferin composition group). The test compound was prepared into a suspension with 0.5% sodium carboxymethylcellulose (0.5% CMC-Na). The normal control group was given an equal volume of vehicle (0.5% CMC-Na) by intragastric administration, and the mangiferin group and the mangiferin composition group were intragastrically administered according to the mangiferin content of 1.0, 3.0, 10.0, and 30.0 mg / kg, and 10ml / kg was administered intragastrically every day Administration 2 times, 5 consecutive times. One hour after the last administration, the eyeball was removed to take blood...

Embodiment 2

[0032] Example 2: Effect of the mangiferin composition of the present invention on serum uric acid in mice with hyperuricemia

[0033]140 healthy male Kunming mice, weighing 18-22 g, were provided by the Experimental Animal Center of Kunming Medical College [Experimental animal production license number: SCXK (Dian) 2005-2008]. Animals were randomly divided into normal control group, hyperuricemia model group, mangiferin: Poria cocos=1:0.1 composition (calculated according to mangiferin content) 0.78, 1.56, 3.13 and 6.25 mg / kg dosage groups and mangiferin: Poria cocos different Proportional dose group. The test compound was formulated into a suspension with 0.5% sodium carboxymethylcellulose (0.5% CMC-Na), and administered by intragastric administration, twice a day for five consecutive times.

[0034] Modeling method of hyperuricemia: mice were intraperitoneally injected with 400 mg / kg oxonic acid potassium salt 2 hours before blood sampling to inhibit uricase activity and c...

Embodiment 3

[0039] Example 3: Effect of the mangiferin composition of the present invention on the excretion of phenol red in normal rats

[0040] 70 male SD rats, weighing 130-150g, were randomly divided into 7 groups, 10 in each group, respectively: normal control group, 3 different dose groups of mangiferin dose group, and the combination of mangiferin:poria cocos=1:30 3 different dosage groups of the compound were administered intragastrically with equal volume of vehicle (0.5% CMC-Na), mangiferin and mangiferin composition (calculated according to mangiferin content) 3.0, 6.0, 12.0mg / kg, and 10ml / kg per day Dosing once, 7 times in total, refer to the literature (H.G Vogel, W.H Vogel, edited. Du Guanhua, Li Xuejun, Zhang Yongxiang, et al. Translated. Pharmacological Experiment Guide--New Drug Discovery and Pharmacological Evaluation. First Edition, 2001, p238-239.) method: 3% phenol red (2.5ml / kg) was injected into the tail vein 30 minutes after the last administration, and 20 μL of b...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of medicines and discloses a composition with a blood uric acid adjusting function. The composition consists of mangiferin and poria in a mass ratio of 1:0.1-100 and can be combined with conventional auxiliary materials to prepare a medicament and functional food with the blood uric acid adjusting function. The composition with the blood uric acid adjusting function can be used for remarkably improving the blood uric acid reduction effect, promoting the discharge of uric acid, compensating the shortcoming of the uric acid discharging function of the mangiferin and greatly reducing the influence on renal functions due to taking the single mangiferin reparation for a long time, and has the effect of assisting in improving the immunity. The medicament and functional food with the blood uric acid adjusting function prepared from the composition disclosed by the invention has the advantages of being simple in production process, stable in product quality, clear in functional factor, outstanding in health care effect, small in taking dosage, safe to use, free from side and toxic effects and the like, and is suitable for being taken by wide population with high uric acid.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition with the function of regulating blood uric acid. Background technique [0002] Hyperuricemia refers to the disorder of the metabolism of purine substances in the human body, and the oxidative metabolite of purine, uric acid, is overproduced or poorly excreted and accumulates in the body, resulting in excessive uric acid in the blood. According to statistics, there are currently about 130 million hyperuricemia patients in China, accounting for about 10% of the total population. Hyperuricemia has become the fourth largest disease after hypertension, hyperlipidemia and hyperglycemia, and is threatening human health. The further development of hyperuricemia will lead to gout. According to statistics, currently 10-15% of the population with hyperuricemia is prone to gout. Gout is a persistently high uric acid level that deposits in the joints, soft tissues, cartilage and kidneys...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/076A61P19/06A61K31/352
Inventor 张伟杨兆祥刘一丹廖荣龚云麒高小惠
Owner KPC PHARM INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com