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Quality detection method of five-flavor manna medicine bath preparation

A quality inspection method and preparation technology, which can be applied to measuring devices, instruments, scientific instruments, etc., can solve problems such as difficulty in ensuring the safety and effectiveness of preparations, no quality control means for Wuwei Ganlu preparations, and inability to accurately control the quality of ephedra.

Active Publication Date: 2012-10-03
JINHE TIBETAN MEDICINE
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Problems solved by technology

[0005] Patented a pharmaceutical composition and preparation process for treating rheumatism and rheumatoid diseases (CN1733025), which did not involve quality testing methods, patented a preparation method and quality control method of Tibetan medicinal bath powder (CN1660051), only determined ephedra The content of ephedrine hydrochloride, ephedrine hydrochloride and pseudoephedrine hydrochloride in ephedra are isomers with similar properties and can be transformed into each other under certain conditions, so only measuring ephedrine hydrochloride can not accurately control the quality of ephedra, so it is difficult to ensure the preparation safe and effective
No reports on more advanced quality control methods for the above-mentioned Wuwei Ganlu preparations were found in the literature search

Method used

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  • Quality detection method of five-flavor manna medicine bath preparation
  • Quality detection method of five-flavor manna medicine bath preparation
  • Quality detection method of five-flavor manna medicine bath preparation

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0052] Experimental example 1: identification experiment (method adopts the method in embodiment 1)

[0053] Wuwei Ganlu medicinal bath powder is provided by Qinghai Jinhe Tibetan Medicine Pharmaceutical Co., Ltd.

[0054] A. TLC identification of ephedra

[0055] Take 5g of the finely ground powder of this product, add 50ml of 1% aqueous hydrochloric acid solution by volume and fraction ratio, ultrasonically treat for 30min, filter, adjust the pH value of the filtrate to 10 with ammonia water, extract it with 20ml of dichloromethane, and extract dichloromethane The methane solution was evaporated to dryness, and the residue was dissolved by adding 2ml of absolute ethanol, which was used as the test solution. Another ephedra reference drug 1g, according to the preparation method of the test solution in the same way to prepare the reference drug solution. Take the ephedra-deficiency negative control substance prepared according to the prescription ratio, and prepare the negat...

experiment example 2

[0070] Experimental example 2: Ephedra content determination experiment

[0071] 1. Instruments, reagents and test samples

[0072] Instruments: Hitachi L-2100 pump, Hitachi L-2400 ultraviolet detector, Shimadzu AUW-220D electronic balance.

[0073] Reference substance: ephedrine hydrochloride reference substance (National Institute for the Control of Pharmaceutical and Biological Products) batch number: 171241-201007, pseudoephedrine hydrochloride reference substance (National Institute for the Control of Pharmaceutical and Biological Products) batch number: 171237-200807; ) Batch number: 121051-200704.

[0074] Sample: Wuwei Ganlu Herbal Bath Powder (Qinghai Jinhe Tibetan Medicine Pharmaceutical Co., Ltd.) Batch number: 20100701, 20100702, 20100703.

[0075] 2. Selection of detection wavelength

[0076] Take the mixed solution of ephedrine hydrochloride reference substance and pseudoephedrine hydrochloride reference substance, scan in the wavelength range of 190~400nm, an...

experiment example 3

[0138] Experimental Example 3: Determination of the content of Rhododendron lanceolata

[0139] 1. Instruments, reagents and test samples

[0140] Instruments: Hitachi L-2100 pump, Hitachi L-2400 ultraviolet detector, Shimadzu AUW-220D electronic balance.

[0141] Reference substance: hyperoside reference substance (National Institute for the Control of Pharmaceutical and Biological Products) batch number: 111521-201004, and rhododendron reference substance (National Institute for the Control of Pharmaceutical and Biological Products) batch number: 121394-200401.

[0142] Sample: Wuwei Ganlu Herbal Bath Powder (Qinghai Jinhe Tibetan Medicine Pharmaceutical Co., Ltd.) Batch number: 20100701, 20100702, 20100703.

[0143] 2. Selection of detection wavelength

[0144] Take the hyperin reference substance solution, scan in the wavelength range of 190~500nm, and select 360nm as the detection wavelength according to the ultraviolet absorption spectrum.

[0145] 3. Mobile phase sel...

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Abstract

The invention discloses a quality detection method of a five-flavor manna medicine bath preparation. The five-flavor manna medicine bath preparation is made from raw materials of Juniperus formosana, ephedra, rhododendron anthopogonoide, myricaria and artemisia sieversiana according to a conventional method of pharmaceutics. On the basis of the primary standard, the thin layer chromatography of ephedra and rhododendron anthopogonoide is revised, the thin layer chromatography of Juniperus formosana and artemisia sieversiana is added. Under the simple and convenient condition of mobile phase, octyl silane bonding silica gel or phenyl bonding silica gel is used as filler, and simultaneously, the contents of ephedrine hydrochloride and pseudoephedrine hydrochloride in the ephedra are detected. The invention also provides a method for measuring the content of hyperoside in five-flavor manna preparation rhododendron anthopogonoide, thus ensuring the safety, effectiveness and controllability of product quality. By the quality detection method, the quality standard of the existing five-flavor manna medicine bath preparation is improved correspondingly.

Description

technical field [0001] The invention relates to a quality detection method of medicines, in particular to a quality detection method of five-flavored nectar medicinal bath preparation. Background technique [0002] Tibetan medicine bath is one of the unique external treatment methods of Tibetan medicine. It is created on the basis of hot spring bath therapy and the basic theory of traditional Tibetan medicine. "Wuwei Ganlu Fang" is the basic formula of Tibetan medicine bath, and has now developed into a classic formula. It has good curative effect in the treatment of various skin diseases, rheumatism and rheumatoid arthritis. [0003] Wuwei Ganlu Fang combines modern new preparation technology to produce Wuwei Ganlu Medicinal Bath Powder, Wuwei Ganlu Medicinal Bath Granules, and Wuwei Ganlu Medicinal Bath Lotion (the above dosage forms are all produced by Jinhe Tibetan Medicine Co., Ltd.). The appearance of the above-mentioned preparation facilitates the medication of pati...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 江玉娟刘玉芹杨敬燕董玉波白文静彭坤王悦
Owner JINHE TIBETAN MEDICINE
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