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Application of naringenin in preparing medicines for resisting apoptosis of retinal photoreceptor cell

A technology of photoreceptors and naringenin, which is applied in drug combinations, sensory diseases, and pharmaceutical formulations, can solve problems such as adverse consequences and different duration of action, and achieve the effect of easy absorption

Inactive Publication Date: 2012-10-10
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that supplementing large doses of these substances can delay the progression of retinal diseases such as RP; 2) neurotrophic factors such as FGF and TGF can delay the apoptosis of photoreceptor cells, but the duration of the effect is different, and it is currently limited to animals Experimental stage; (3) Calcium antagonists can delay the development of photoreceptor cell apoptosis in rd mice, but how to determine the safe dose of calcium antagonists for RP treatment, whether long-term application will have adverse consequences on the body, etc., need to be further investigated. Research

Method used

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  • Application of naringenin in preparing medicines for resisting apoptosis of retinal photoreceptor cell
  • Application of naringenin in preparing medicines for resisting apoptosis of retinal photoreceptor cell
  • Application of naringenin in preparing medicines for resisting apoptosis of retinal photoreceptor cell

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: (eye drops)

[0023] 1. Take 400ml of water for injection, add 10g of polycarbophil under stirring, swell for more than 2 hours, adjust the pH value to 6.0-6.5 with NaOH solution with a concentration of 2mol / L, sterilize by autoclaving, and use it as solution I for later use.

[0024] 2. Take 400ml of water for injection, add 150g of hydroxypropyl-β-cyclodextrin, stir to dissolve, add 10g of naringenin and sonicate for 2h to dissolve; then add 2g of poloxamer 407, sonicate for 0.5h to dissolve; add 1g of edetic acid Disodium, 2g sodium chloride and 0.1g benzalkonium chloride are stirred and dissolved, and used as solution II for subsequent use;

[0025] 3. Mix solution Ⅰ and solution Ⅱ evenly under constant stirring, add water for injection to make up to 1000ml, and finally adjust the pH value to 6.0-7.0 with filter-sterilized sodium hydroxide solution with a concentration of 2mol / L, stir well and Filling 100 pieces. Contains 10mg of naringenin per ml. ...

Embodiment 2

[0027] Embodiment 2: (tablet)

[0028] 1. Preparation of tablet core: Pass 75g of naringenin and 23g of starch through an 80-mesh sieve, mix well, add an appropriate amount of 5% PVP K30 aqueous solution to make a soft material, granulate with a 16-mesh sieve, and place at 60°C-70°C After drying, use a 16-mesh sieve to sieve the granules, add 2 g of sodium carboxymethyl starch and 0.5 g of magnesium stearate, mix well and press into 1000 tablets, each containing 75 mg of naringenin.

[0029] 2. Preparation of coating liquid: take 10 g of HPMC ethanol solution with a concentration of 6%, 0.20 g of Tween 80, 0.30 g of polyethylene glycol 6000 and 0.50 g of talcum powder, and mix well;

[0030] 3. Coating: Put the tablet core into the coating pan, spray the coating solution, and control the weight gain of the coating to 5%;

[0031] 4. Usage and dosage: 2-8 tablets each time, 1-3 times a day. 10-20 days a course of treatment.

Embodiment 3

[0032] Embodiment 3: (oral suspension)

[0033] 1. Take 5g of naringenin, 200ml of glycerin and 5g of Tween 80 and grind them into a uniform paste in a mortar to prepare a naringenin paste for later use;

[0034] 2. Dissolve 5g of sodium benzoate, 20g of citric acid, 0.5g of aspartame and 0.5g of strawberry essence in an appropriate amount of purified water to prepare solution I;

[0035] 3. Take 20g of xanthan gum and use appropriate amount of purified water to make a glue, and add it to the naringenin paste while stirring to prepare solution II;

[0036]4. Add solution I to solution II under stirring, stir well, add pure water to 1000ml, stir well to get it. Each milliliter of oral suspension contains 5 mg of naringenin.

[0037] 5. Usage and dosage: 5-40ml each time, three times a day. 10-20 days is a course of treatment.

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Abstract

The invention relates to a flavonoid organic effective component-containing medicinal preparation, in particular to the application of naringenin in preparing medicines for resisting apoptosis of a retinal photoreceptor cell. According to the application, the compound naringenin embodying the uses has a protective action on the photochemical damage of the retinal photoreceptor cell, can be used for resisting the apoptosis of the retinal photoreceptor cell and can be used for preparing various medicines for resisting the apoptosis of the retinal photoreceptor cell so as to be in favor of increasing the life quality of human.

Description

technical field [0001] The invention relates to medical preparations, in particular to medical preparations containing flavonoid organic active ingredients. technical background [0002] Photoreceptor cells refer to sensory cells that can sense light stimuli and generate impulses that are transmitted to the central nervous system. There are two main types of photoreceptor cells in humans, rods and cones. If photoreceptor cells undergo apoptosis, it will be difficult to regenerate and repair, which will lead to a variety of refractory blinding diseases, such as retinitis pigmentosa (RP), diabetic retinopathy (diabetic retinopathy, DR) and retinal detachment. [0003] Retinal diseases caused by photoreceptor cell apoptosis can be treated by photodynamic therapy, intravitreal injection of various anti-vascular endothelial growth factor (VEGF) drugs, etc. to inhibit neovascularization, and vitreoretinal surgery. These methods are mainly used in the late stage of the disease. P...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P27/02A61P9/10
Inventor 林宝琴
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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