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Hyperoxia compound glycine pyridoxal electrolyte injecta

A technology of electrolyte injection and hyperoxia compound glycopyrrole, which can be used in blood diseases, extracellular fluid diseases, active ingredients of alkaline/alkaline earth metal chlorides, etc., can solve swelling, aggravate renal function damage, affect clinical safety and be widely used and other problems to achieve the effect of reducing intraocular pressure, protecting important organs from hypoxia damage, reducing injection pain and nephrotoxicity

Active Publication Date: 2014-07-02
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] ② When large doses of dehydrating drugs are rapidly infused, the high osmotic pressure in the renal tubules can cause swelling of the renal tubular epithelial cells and aggravate the damage of renal function;
[0005] ③At present, all the dehydration medicines used clinically at home and abroad cannot not only have dehydration effects, but also supplement oxygen supply, supplement electrolytes and improve important organs at the same time;
[0006] ④ Mannitol, the most commonly used clinical dehydration drug, crystallizes when the ambient temperature is lower than 15°C, which greatly affects clinical safety and wide application

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment 1

[0026] Embodiment 1: Preparation of hyperoxic compound glycoside sodium lactate injection

[0027] 1. Prescription:

[0028]

[0029]

[0030] 2. Preparation method:

[0031] (1) Prepare Lactated Ringer's Injection according to the ministerial standard: 30.0Kg sodium chloride, 15.5Kg sodium lactate, 1.0Kg calcium chloride, 1.5Kg potassium chloride are fully dissolved in the In an appropriate amount of water for injection, the total amount is 5000L to make Lactated Ringer's Injection according to the ministerial standard;

[0032] (2) Preparation of glycopyrrolate sodium lactate injection: 500.0Kg mannitol powder and 500.0Kg piracetam powder were fully dissolved in 5000L lactated Ringer's injection in step (1) using a vibrating mixer to make glycosides Sodium Pilactate Injection;

[0033] (3) Preparation of high-oxygen compound sodium glycoside lactate injection: pre-fill a 5000L release storage tank with medical pure oxygen, and input 5000L of glycopyril sodium lactat...

Embodiment 2

[0035] Embodiment 2: the preparation of hyperoxic compound sodium glycoside injection

[0036] 1. Prescription:

[0037]

[0038]

[0039] 2. Preparation method:

[0040](1) Prepare Lactated Ringer's Injection according to the ministerial standard: 58.5Kg sodium chloride, 61.2Kg sodium acetate, 3.33Kg calcium chloride, 3.0Kg potassium chloride are fully dissolved in a vibrating mixer according to the routine operation of medical liquids In an appropriate amount of water for injection, the total amount is 5000L, and made into Ringer's Acetate Injection issued by the Ministry;

[0041] (2) Preparation of Glycylic Electrolyte Injection: 500.0Kg of mannitol powder and 500.0Kg of piracetam powder were fully dissolved in 5000L of Ringer's Acetate Injection in step (1) using a vibrating mixer to make Glycyrrhiza. Sodium Piacetic Acid Injection;

[0042] (3) Preparation of high-oxygen compound glycopyrrole electrolyte injection: pre-fill a 5000L release storage tank with medi...

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Abstract

The invention discloses hyperoxia compound glycine pyridoxal electrolyte injecta which contains high-concentration dissolved oxygen, electrolyte, mannitol and piracetam. After intravenous infusion, the hyperoxia compound glycine pyridoxal electrolyte injecta can not only play a conventional role of dehydration, but also notably improve oxygen content of blood, replenish loss of the electrolyte caused by the dehydration, play important roles in lightening electrolyte disturbance and protecting important viscera from anoxia damage, and be safely and widely used to cure encephaledema, reduce intracranial pressure and intraocular pressure, effectively reduces occurrence rates of various complications, and has good double functions of cerebral protection. A plurality of kinds of effective composite ingredients contained by the hyperoxia compound glycine pyridoxal electrolyte injecta respectively reduce working concentration and working dosage of single drug. The hyperoxia compound glycine pyridoxal electrolyte injecta greatly reduces injection pains and renal toxicity, overcomes three big difficult problems that mannitol is crystallized below 15 DEG C and the like, is favorable for being used for emergency treatment at different environment temperatures, and has rather important clinical application values, and wide social and economic benefits.

Description

technical field [0001] The invention belongs to medical liquids, and particularly relates to a high-oxygen compound glycopyrrole electrolyte injection. The injection contains high-concentration dissolved oxygen and electrolytes of physiological concentration, which can obtain dehydration, replenish electrolytes, assist oxygen supply, and improve brain metabolism and cerebral insufficiency. The hemoprotective effect can be applied to compound injections of osmotic diuretics and brain protection. Background technique [0002] Dehydrating drugs, also known as osmotic diuretics (Osmotic diuretics), are a class of drugs that can promote the excretion of water between tissues. Including mannitol, sorbitol, hypertonic glucose, etc. These drugs immediately form hyperosmotic pressure in plasma, glomerular filtrate and renal tubule luminal fluid after intravenous injection, so that the electrolyte in the tubule fluid is diluted and the concentration is reduced, thereby Make renal tub...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61P7/10A61K31/047A61K31/19A61K31/4015
Inventor 徐礼鲜王晓娟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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