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Method for preparing medical lactide

A lactide and medical technology, applied in the field of polymer compound preparation, can solve the problems of incapable of large-scale production, complicated process, low yield, etc., to ensure stability and product quality, facilitate industrial production, and simple reaction operation Effect

Active Publication Date: 2013-01-09
上海绿色盛世生态材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] 2. As the distillation of lactide gradually decreases, the reactant becomes viscous and carbonized, which makes it difficult to distill and the yield decreases;
[0016] 3. The lactide distilled in the early stage and the lactide distilled in the later stage are unstable in terms of physical properties, and the variability is relatively large
[0023] 1. The reactant becomes viscous and carbonized as the distillation of lactide decreases, resulting in difficulty in distillation and lower yield;
[0024] 2. There are dangers in the operation and recovery of heated high-temperature gas
[0031] 1. The color of lactide is yellow;
[0032] 2. The process is complicated, the production time is too long, and it is impossible to produce on a large scale

Method used

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  • Method for preparing medical lactide
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Examples

Experimental program
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Effect test

Embodiment 1

[0054] Add 50kg of L-lactic acid to the reaction kettle to replace the air in the reaction kettle (vacuumize-nitrogen, cycle 3 times); the heating medium is oil, so that the oil temperature rises to 120°C, slowly vacuumize to 200Kpa, and condense and dehydrate ( There is water until the condenser tube flows out), and the water gradually stops after 3 hours;

[0055] After passing nitrogen to normal pressure and draining water, add 50g of antimony trioxide and 25kg of diethyl phthalate; the oil temperature is raised to 170°C, and the vacuum is continuously and slowly pumped to 30Kpa, and the reaction is carried out for 4 hours; at this time, the lactic acid is initially removed ( LA) through the dehydration polycondensation of intermolecular hydroxyl and carboxyl groups, the lactic acid molecules start to polymerize;

[0056] Then pass nitrogen to normal pressure to drain water, then replace the heating medium with water, control the temperature at 175°C, continue vacuuming to ...

Embodiment 2

[0059] Other conditions were the same as in Example 1, except that 50 kg of D,L-lactic acid was added as raw material to prepare D,L-lactide in the form of white crystals.

Embodiment 3

[0061] Other conditions were the same as in Example 1, except that L-lactic acid and diethyl phthalate in a weight ratio of 1:1 were added to prepare L-lactide in the form of white crystals.

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Abstract

The invention relates to the method for preparing medical lactide. The method includes: adding catalyst and high boiling-point solvent in lactic acid for condensation polymerization to enable the lactic acid to generate lactic-acid oligomer, and adding catalyst in the generated lactic-acid oligomer for depolymerization to obtain the medical lactide. The high boiling-point solvent is added during the condensation polymerization, so that a reaction system during depolymerization cannot become viscous, and is less prone to steam out, carbonize and turn yellow caused by distillation and reduction of lactide, stability of production process, product quality and variability of physical indexes are guaranteed; and the method for preparing medical lactide is high in yield, simple in reaction operation, free of danger, short in production time and beneficial to industrial production, and has quite high economic value.

Description

technical field [0001] The invention relates to the field of preparation of polymer compounds, in particular to a method for preparing medical lactide. Background technique [0002] Medical lactide is an important raw material for the synthesis of medical polylactic acid. As a new green material in the 21st century, medical polylactic acid material has broad prospects in biomedical materials. Polylactic acid is non-toxic, non-irritating, has excellent biocompatibility, bioabsorbability and biodegradability, and also has the advantages of high mechanical strength, stable chemical properties and easy processing. It can be used as a biomedical material for Drug sustained release carrier, surgical implant materials, such as: medical sutures, ophthalmic implant materials, fracture internal fixation materials, and dressing materials for large area trauma (especially burns), artificial blood vessels and tissue engineering scaffolds (such as artificial skin), etc. . [0003] In th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D319/12C08G63/08
Inventor 王伟王威朱士燕
Owner 上海绿色盛世生态材料有限公司
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