Method for preparing medical lactide
A lactide and medical technology, applied in the field of polymer compound preparation, can solve the problems of incapable of large-scale production, complicated process, low yield, etc., to ensure stability and product quality, facilitate industrial production, and simple reaction operation Effect
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Embodiment 1
[0054] Add 50kg of L-lactic acid to the reaction kettle to replace the air in the reaction kettle (vacuumize-nitrogen, cycle 3 times); the heating medium is oil, so that the oil temperature rises to 120°C, slowly vacuumize to 200Kpa, and condense and dehydrate ( There is water until the condenser tube flows out), and the water gradually stops after 3 hours;
[0055] After passing nitrogen to normal pressure and draining water, add 50g of antimony trioxide and 25kg of diethyl phthalate; the oil temperature is raised to 170°C, and the vacuum is continuously and slowly pumped to 30Kpa, and the reaction is carried out for 4 hours; at this time, the lactic acid is initially removed ( LA) through the dehydration polycondensation of intermolecular hydroxyl and carboxyl groups, the lactic acid molecules start to polymerize;
[0056] Then pass nitrogen to normal pressure to drain water, then replace the heating medium with water, control the temperature at 175°C, continue vacuuming to ...
Embodiment 2
[0059] Other conditions were the same as in Example 1, except that 50 kg of D,L-lactic acid was added as raw material to prepare D,L-lactide in the form of white crystals.
Embodiment 3
[0061] Other conditions were the same as in Example 1, except that L-lactic acid and diethyl phthalate in a weight ratio of 1:1 were added to prepare L-lactide in the form of white crystals.
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