Automated synthesizer of <18>F-marked PET (positron emission tomograph)/CT (computerized tomograph) molecular image probe

Abstract

The invention belongs to the field of medical and molecular imaging, and relates to a universal automated synthesizer of an <18F>-marked PET (positron emission tomograph) / CT (computerized tomograph) molecular image probe. The automated synthesizer comprises cylinders having different specifications and being positioned at different positions, a reagent bottle, a reaction bottle, a heating / cooling module, a control electromagnetic valve, a PTFE pipe, an N2 pipe and a vacuum pipe, the synthesizer can separate the opened / atmospheric chemical treatment from closed / high-temperature chemical treatment process in the same reaction bottle at different positions, so that corrosion of high-temperature solution to various control elements can be avoided. Various common <18>F-marked PET / CT molecular image probes can be synthesized and comprise <18>F-FDG, <18>F-FLT, <18>F-FES, <18>F-FMISO, <18>F-FHBG, <18>F-FET, <18>F-FAC, <18>F-FeCH, <18>F-FCH and <18>F-marked intermediate <18>F-SFB and <18>F-FBEM. The synthesizer is simple in structure, stable in performance, convenient to use, and suitable for synthesis, research and development of various <18>F-marked PET / CT molecular image probes.

Description

technical field [0001] The invention belongs to the field of nuclear medicine and molecular imaging, and relates to a 18 A general-purpose automatic synthesizer for F-labeled PET / CT molecular imaging probes. Background technique [0002] At present, molecular imaging is the most active frontier research field in the field of biomedicine. It directly "sees" the biochemical changes and manifestations related to the growth and development of organisms and the occurrence and development of diseases in the living body with three-dimensional images at the molecular, cellular and subcellular levels. , characteristics and quantification. Nuclear medicine, including positron emission computed tomography (PET), single photon emission computed tomography (SPECT), and its fusion modes with CT PET / CT, SPECT / CT, is the origin of molecular imaging, and is used in clinical and basic research has been widely used and has become the gold standard for other molecular imaging modalities. Com...

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Problems solved by technology

[0004] However, there are several disadvantages in the existing automatic synthesizer: 1. because it is specially designed for [ 18 F] designed for automated synthesis of FDG and cannot be flexibly used in [ 18 F] other than FDG 18 The automatic synthesis of F-labeled PET / CT molecular imaging probes lacks versatility and flexibility; ②The existing commercialized and multifunctional automatic synthesizers can be used for several 18 Synthesis of F-labeled PET / CT molecular imaging probes, but its design is complex and expensive; ③The amount of reagents is large, especially the amount of labeled precursor compounds, and the production cost is high.

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