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Nano magnetic fluid composite material coated with polyamino acid and preparation method thereof

A polyamino acid and nano-magnetic fluid technology is applied in the field of magnetic fluid to achieve the effects of good crystallinity, strong hydrophilicity and low synthesis cost

Inactive Publication Date: 2015-10-14
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods can obtain water-soluble magnetic nanoparticles, but they can be easily and quickly prepared with good hydrophilicity, strong biocompatibility, biocoupling, especially polyamino acid coating, strong magnetism, and high T 2 A method for weighting NMR signals of magnetic nanoparticles has not been reported

Method used

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  • Nano magnetic fluid composite material coated with polyamino acid and preparation method thereof
  • Nano magnetic fluid composite material coated with polyamino acid and preparation method thereof
  • Nano magnetic fluid composite material coated with polyamino acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] a. take 0.2g molecular weight and be the solid powder polysuccinimide of 6000 in the Teflon reactor;

[0032] b. Dissolve 0.25g of NaOH solid powder in 25ml of deionized water, pour it into the Teflon reactor in step a after the NaOH is completely dissolved, stir and mix to dissolve completely;

[0033] c. 0.14g FeCl 3 ·6H 2 O (0.5mmol) and 0.39g Fe(NH 4 ) 2 (SO 4 ) 2 ·6H 2 Add O (1mmol) into 10ml of deionized water, stir to dissolve, mix with the solution obtained in step b, and continue stirring for 5-15 minutes; seal the Teflon reactor with a stainless steel sleeve, and react at 140°C for 2 hours;

[0034] d. Discard the supernatant after cooling, collect the lower solid by magnetic separation, dissolve it in water, add ethanol to precipitate and centrifuge and wash 2-5 times, and finally disperse the product stably in 5-10ml deionized water, that is, polyamino acid coated Ferroferromagnetic nanoparticle composite material.

Embodiment 2

[0036] a. take 0.2g molecular weight and be the solid powder polysuccinimide of 6000 in the Teflon reactor;

[0037] b. Dissolve 0.25g of NaOH solid powder in 25ml of deionized water, pour it into the Teflon reactor in step a after the NaOH is completely dissolved, stir and mix to dissolve completely;

[0038] c. 0.14g FeCl 3 ·6H 2 O (0.5mmol) and 0.39g Fe(NH 4 ) 2 (SO4) 2 ·6H 2 Add O (1mmol) into 10ml of deionized water, stir to dissolve, mix with the solution obtained in step b, and continue to stir for 5-15 minutes; seal the Teflon reactor with a stainless steel sleeve, and react at 150°C for 2 hours;

[0039] d. Discard the supernatant after cooling, collect the lower solid by magnetic separation, dissolve it in water, add ethanol to precipitate and centrifuge and wash 2-5 times, and finally disperse the product stably in 5-10ml deionized water, that is, polyamino acid coated Ferroferromagnetic nanoparticle composite material.

Embodiment 3

[0041] a. take 0.2g molecular weight and be the solid powder polysuccinimide of 6000 in the Teflon reactor;

[0042] b. Dissolve 0.25g of NaOH solid powder in 25ml of deionized water, pour it into the Teflon reactor in step a after the NaOH is completely dissolved, stir and mix to dissolve completely;

[0043] c. 0.14g FeCl 3 ·6H 2 O (0.5mmol) and 0.39g Fe(NH 4 ) 2 (SO 4 ) 2 ·6H 2 Add O (1mmol) into 10ml of deionized water, stir to dissolve, mix with the solution obtained in step b, and continue to stir for 5-15 minutes; seal the Teflon reactor with a stainless steel sleeve, and react at 160°C for 2 hours;

[0044] d. Discard the supernatant after cooling, collect the lower solid by magnetic separation, dissolve it in water, add ethanol to precipitate and centrifuge and wash 2-5 times, and finally disperse the product stably in 5-10ml deionized water, that is, polyamino acid coated Ferroferromagnetic nanoparticle composite material.

[0045] The state (left) and the s...

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Abstract

The invention discloses a polyamino acid coated nano-magnetic fluid composite material and a preparation method for the same, and belongs to the technical field of magnetic fluids. A polyaspartic acid obtained by the hydrolysis of polysuccinimide is coated on the surface of a magnetic ferroferric oxide nano-particle, a part of carboxyl groups are coupled with the ferroferric oxide nano-particle, and a part of carboxyl groups are free outside the particle. The polyamino acid coated nano-magnetic fluid composite material can be obtained by reacting a 6,000-molecular weight mixed solution of the polysuccinimide and a solution of sodium hydroxide with FeCl3 and Fe(NH4)2(SO4)2 in a Teflon reaction kettle, and performing separation and washing. The material synthesized by the method is high in crystallinity and magnetism and quick in T2 weighted signal response.

Description

Technical field [0001] The invention relates to a polyamino acid-coated ferroferric oxide nanomagnetic fluid composite material and a preparation method thereof, belonging to the field of magnetic fluid technology, and particularly relates to medical applications. Technical background [0002] Nanomaterials refer to nanoparticles with a size between 1-100nm. And it has some special effects that are different from conventional objects, such as small size effect, surface effect, quantum size effect, and macroscopic quantum orbit effect. The properties of magnetic nanomaterials are different from conventional magnetic materials because the characteristic physical lengths related to magnetism are exactly in the nanometer range, such as: magnetic single domain size, superparamagnetic critical size, exchange interaction length, and electron mean free path are roughly on the order of 1-100nm. When the size of the magnetic body is equivalent to these characteristic physical lengths...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/44C01G49/08B82Y30/00
Inventor 汪乐余彭姗
Owner BEIJING UNIV OF CHEM TECH
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