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V-shaped vessel ligature clamp with single-layer structure and method for preparing V-shaped vessel ligature clamp

A technique for ligating blood vessels and clamping arms, which is applied in the field of preparation of the blood vessel ligation clips, can solve the problems of little degradation time of the blood vessel ligation clips, insufficient friction of the locking mouth, prolonging the operation time and the like, and achieves the controllability of the degradation time, Easy to operate and easy to clip blood vessels

Active Publication Date: 2013-04-03
HANGZHOU MEDZONE BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent Document 1 discloses a vascular clip made of elastic material. In actual use, the friction force of the locking mouth of the vascular clip is not enough, and it is easy to cause the vascular clip to jump, resulting in reapplying the vascular clip and prolonging the operation time.
[0005] Although the performance of vascular ligation clips has been greatly improved after years of research in the industry, the improvement of vascular ligation clips has always been carried out around degradable aliphatic polyester homopolymers or copolymers, and the regulation of vascular ligation clip degradation There are few literature reports on time

Method used

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  • V-shaped vessel ligature clamp with single-layer structure and method for preparing V-shaped vessel ligature clamp
  • V-shaped vessel ligature clamp with single-layer structure and method for preparing V-shaped vessel ligature clamp
  • V-shaped vessel ligature clamp with single-layer structure and method for preparing V-shaped vessel ligature clamp

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Experimental program
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preparation example Construction

[0043] In addition to the above-mentioned biodegradable aliphatic polyester material, the raw materials for the preparation of the vascular ligation clip of the present invention may contain other conventional auxiliary agents that do not impair its biodegradability, such as medical pigments such as D&C Purple No. 2.

[0044] After the vascular ligation clip is prepared, the present invention further studies its degradation behavior in a buffer solution simulating a body fluid environment, its cytotoxicity by MTT method, its cytocompatibility by in vitro culture method and coagulation by PT. Enzyme time, TT thrombin time and APTT activated partial thromboplastin time were used to detect its coagulation effect.

[0045] In the present invention, the simulated body fluid degradation test is carried out on the vascular ligation clip, and it is found that to make the vascular ligation clip have a longer degradation time (12-14 months, etc.), while reducing the proportion of amino a...

Embodiment

[0052] Hereinafter, an embodiment of the present invention will be specifically described by showing examples and comparative examples. However, the present invention is not limited to the following examples.

[0053] (Synthesis of Aliphatic Polyester Materials)

Synthetic example 1

[0054] Synthetic example 1 to the preparation of dioxanone-glutamic acid copolymer 1

[0055] The two monomers of p-dioxanone and glutamic acid were mixed in a molar ratio of 70:30, weighed 300g and added to the reactor, and 0.02% stannous octoate catalyst was added to the reactor. The reaction system was sealed, and nitrogen gas was introduced to protect the reaction. The temperature of the reaction system was controlled at 120° C., and the reaction was carried out for 10 hours. The reactants were chopped to make pellets with a particle size of 1-8 mm, and 191 g of pellets were obtained by weighing, with a yield of 95.5%. The above pellets were dissolved in a phenol / tetrachloroethane (2:3 / V:V) mixed solution, and the intrinsic viscosity of the copolymer was measured as 3.28dL / g with an Ubbelohde viscometer in a constant temperature water bath at 25°C.

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Abstract

The invention provides an absorbable vessel ligature clamp for a surgical operation and a method for preparing the absorbable vessel ligature clamp. The vessel ligature clamp is formed by the fusing and injection molding of a raw material which contains a biodegradable aliphatic polyester material by using a specifically-shaped mold. The vessel ligature clamp has a single-layer structure and is V-shaped. The ligature clamp is high in biocompatibility. Degradation time is controllable and can be matched with a vessel healing period after operation.

Description

technical field [0001] The invention relates to a single-layer, V-shaped structure bioabsorbable blood vessel ligation clip for surgery prepared from raw materials containing biodegradable aliphatic polyester materials. In detail, it relates to a bioabsorbable vascular ligation clip for surgical operations, which is made of biodegradable aliphatic polyester material and has flexibility, good clamping force and optimized structure. In addition, the present invention also relates to a preparation method of the blood vessel ligation clip. Background technique [0002] Hemostasis technology is one of the cores of basic surgical techniques. Surgical operations on any part of the human body almost without exception involve bleeding and hemostasis. , equipment, anesthesia, etc., including a complete technical system. Finding the bleeding site and treating the bleeding vessels is the real key to stop bleeding. Traditional methods such as ligation, suture, packing, and heat hemost...

Claims

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Application Information

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IPC IPC(8): A61B17/122A61L31/06
Inventor 裴明黎张洁郑海菁
Owner HANGZHOU MEDZONE BIO-TECH CO LTD
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