V-shaped vessel ligature clamp with single-layer structure and method for preparing V-shaped vessel ligature clamp
A technique for ligating blood vessels and clamping arms, which is applied in the field of preparation of the blood vessel ligation clips, can solve the problems of little degradation time of the blood vessel ligation clips, insufficient friction of the locking mouth, prolonging the operation time and the like, and achieves the controllability of the degradation time, Easy to operate and easy to clip blood vessels
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[0043] In addition to the above-mentioned biodegradable aliphatic polyester material, the raw materials for the preparation of the vascular ligation clip of the present invention may contain other conventional additives that do not impair its biodegradability, such as D&C Purple No. 2 and other medical pigments.
[0044] After the vascular ligation clip is prepared, the present invention further studies its degradation behavior in a buffer solution that simulates a body fluid environment, uses MTT method to study its cytotoxicity, uses in vitro culture method to study its cell compatibility and uses PT to coagulate blood. Proenzyme time, TT thrombin time, and APTT activated partial thromboplastin time were used to test the coagulation effect.
[0045] In the present invention, the vascular ligation clip is subjected to a simulated body fluid degradation test, and it is found that in order to make the vascular ligation clip have a longer degradation time (12-14 months, etc.), while r...
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[0051] Example
[0052] Hereinafter, examples and comparative examples are shown to specifically describe embodiments of the present invention. However, the present invention is not limited to the following examples.
[0053] (Synthesis of aliphatic polyester material)
Example Embodiment
[0054] Synthesis Example 1 Preparation of p-dioxanone-glutamic acid copolymer 1
[0055] The two monomers of p-dioxanone and glutamic acid were mixed with a molar ratio of 70:30, weighed 300g and added into the reactor, and 0.02% stannous octoate catalyst was added into the reactor. The reaction system was sealed, and nitrogen was introduced to protect the reaction. The temperature of the reaction system was controlled to 120°C, and the reaction was conducted for 10 hours. The reactant was chopped into pellets with a particle size of 1-8 mm, and 191 g of pellets were weighed with a yield of 95.5%. The above pellets were dissolved in a phenol / tetrachloroethane (2:3 / V:V) mixed solution, and the intrinsic viscosity of the copolymer was 3.28 dL / g as measured by a Ubbelohde viscometer in a constant temperature water bath at 25°C.
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