Enhanced optical microfluidic sensor device coated with dielectric layer and method

A sensing device and enhanced technology, applied in the measurement of phase influence characteristics, etc., can solve the problems of not considering thick-walled microtubes, the limitation of the object to be detected, and limit the applicability of analysis, so as to improve the detection limit, simplify the calibration, reduce the Small volume effect
CN103048293AActive Publication Date: 2013-04-17TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2013-04-17

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Abstract

The invention discloses an enhanced optical microfluidic sensor device coated with a dielectric layer. The enhanced optical microfluidic sensor device coated with the dielectric layer comprises a spectrum analyzing device, a prism coupling device, and an enhanced optical microfluidic sensor of which the inner wall is coated with a high-refractivity dielectric layer, wherein light output by a light source is coupled into the enhanced optical microfluidic sensor through the prism coupling device; the enhanced optical microfluidic sensor is a sensing passage and a transferring passage; and the spectrum analyzing device is used for collecting and analyzing the wavelength of light coupled and output by the enhanced optical microfluidic sensor so as to realize sensing. The enhanced optical microfluidic sensor uses a microtube of which the inner surface is coated with the high-refractivity dielectric layer as an optical resonant cavity, so that the detection sensitivity is improved, and the optical resonant cavity, the sensing passage and the fluid transferring passage are integrated, with an advantage of integration; and the enhanced optical microfluidic sensor device coated with the dielectric layer is applicable to various ways and can achieve mass production by an existing technology.
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Description

technical field

[0001] The invention relates to a high-sensitivity optical microfluidic resonance sensing device and method, in particular to an enhanced optical microfluidic sensing device and method in which the inner surface of a microtube is coated with a high refractive index medium layer. Background technique

[0002] Label-free microfluidic biosensors based on optical refractive index detection can directly measure molecular interactions, avoiding the need for special fluorescent markers, complicated labeling, weakened biological activity due to labeling, and interference with the reaction itself. and other adverse effects, it has broad application prospects in life sciences, medical research and other fields.

[0003] The optical microresonator uses total reflection to completely confine the light in the microcavity, forming a standing wave to generate a whispering gallery resonance mode (Whisper Gallery Mode, WGM). Because of total reflection, the leakage loss is ve...

Claims

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