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Salvianolic acid A freeze-dried powder and application thereof to medicine preparation

A technology for freeze-dried powder injection and salvianolic acid, which is applied in the field of salvianolic acid A freeze-dried powder for injection and preparation of medicines

Active Publication Date: 2013-06-12
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is still a big gap between this and the requirements of actual industrialization

Method used

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  • Salvianolic acid A freeze-dried powder and application thereof to medicine preparation
  • Salvianolic acid A freeze-dried powder and application thereof to medicine preparation
  • Salvianolic acid A freeze-dried powder and application thereof to medicine preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0114] Take Danshen medicinal material, crush it into 6-mesh granules, add 7 times the amount of 92°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to relative Density 1.20 (60°C), add ethanol to make the alcohol content at 70%, let it stand, filter, the filtrate is decompressed to recover ethanol and concentrate until it has no alcohol smell; add water to dilute to contain salvianolic acid B 20mg per 1ml, and use 10 mg of salvianolic acid B in the aqueous solution % NaOH to adjust the pH to 4.0, add 0.5% ZnCl 2 As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the ratio of th...

Embodiment 2

[0117] Take Salvia miltiorrhiza, crush it into particles with a diameter of about 2mm, add 7 times the amount of 90°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to Relative density 1.18 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates to no alcohol smell; add water to dilute to contain salvianolic acid B20mg per 1ml, and use 10 mg of salvianolic acid B in the aqueous solution % NaOH to adjust the pH to 5.5, add 0.5% ZnCl 2 As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the rat...

Embodiment 3

[0120] Take Salvia miltiorrhiza, cut into decoction pieces, add 8 times the amount each time, soak in water at 85°C for 3 times, stir at a speed of 20 rpm, and extract with warm soaking for 2.5 hours each time; the extract is concentrated under reduced pressure to a relative density of 1.17 (60 ℃), add ethanol to make the alcohol content at 75%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until it has no alcohol smell; add water to dilute to contain salvianolic acid B 15mg per 1ml, and use 10% potassium hydroxide in the aqueous solution Adjust pH to 5.0, add 0.6% ZnCl 2 As a catalyst, heat conversion at 120°C for 3.5 hours, adjust the pH value of the conversion liquid to 2.5 with 15% hydrochloric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 5 mg of salvianolic acid A per 1 ml, pass through HPD-100 macroporous resin column layer Analysis and separation, the ratio of the loading amount of salviano...

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Abstract

The invention relates to application of a salvianolic acid A freeze-dried powder to preparation of medicine for preventing and treating ischemic heart disease. The salvianolic acid A freeze-dried powder contains a salvianolic acid A main ingredient, a filler and an antioxidant in the following weight proportion: 10g-80g of the salvianolic acid A main ingredient, 10g-80g of the filler and the antioxidant accounting for 0.01%-0.2% of the total amount. The filler is one or more selected from mannitol, glucose and lactose. The antioxidant is one or more selected from vitamin C, thiourea, sodium bisulfite and sodium pyrosulfite. The salvianolic acid A main ingredient comprises salvianolic acid A more than 93% and less than 100%, and other four components: 0.1%-2% of alkannic acid, 0.1%-2% of rosmarinic acid, 0.1%-2% of salvianolic acid B, and 0.1%-2% of salvianolic acid C.

Description

technical field [0001] The invention relates to a salvianolic acid A freeze-dried powder injection and its use in preparing medicines. technical background [0002] Ischemic heart disease (IHD) is myocardial damage resulting from an imbalance between coronary blood flow and myocardial demand caused by alterations in the coronary circulation, most commonly due to coronary atherosclerosis, coronary thrombosis, and coronary artery spasm , accounting for about 90% of ischemic heart disease. What they have in common is that myocardial ischemia, hypoxia, myocardial energy metabolism is abnormal, and cannot support the normal work of the heart due to the contradiction between oxygen supply and demand caused by insufficient myocardial blood supply. Myocardial infarction is life-threatening. According to the location, scope and severity of coronary artery disease, and the degree of myocardial ischemia, it can be divided into five clinical categories: asymptomatic myocardial ischemi...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K31/216A61K9/19A61P9/10A61P9/00A61P7/02A61J3/02C07C69/732C07C67/32
Inventor 崔刚欧阳婷李志勇程帆刘鹏刘恩位王振罗恒真
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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