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Traditional Chinese medicine perfusate containing total alkaloids of Sophora fructus for treating dairy cow mastitis and endometritis and preparation method thereof

A technology of endometritis and Sophora sophora, which is applied in the field of traditional Chinese medicine perfusate containing total alkaloids of Sophora sophora, can solve the problems of reducing milk production years of dairy cows, easy recurrence, high incidence of mastitis and endometritis in dairy cows, and achieves Conducive to stability and quality controllability, recovery of overall function and body condition, and less likely to produce drug resistance

Active Publication Date: 2015-09-09
GUANGDONG HINAPHARM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The occurrence of the disease directly affects the quality and output of milk, and also reduces the milk production life of dairy cows and increases the elimination rate
The disease has a high clinical incidence and is difficult to control, causing huge economic losses to the dairy farming industry
[0004] At present, there are many prevention and treatment measures for mastitis and endometritis in dairy cows, such as antibacterial and anti-inflammatory, enhancing the body's resistance, vaccination and good management and feeding, etc., but the incidence of mastitis and endometritis in dairy cows is still very high
In particular, antibiotics and chemical drugs commonly used in clinical treatment of dairy cow mastitis and endometritis, first of all, the clinical symptoms of dairy cow mastitis and endometritis disappear, but it is easy to relapse; secondly, antibiotics and chemical drug antibacterial drug resistance It is ubiquitous, and the dosage of antibiotics and chemical drugs is increasing continuously, but the clinical efficacy is not good, coupled with antibiotic residues, it directly endangers human health

Method used

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  • Traditional Chinese medicine perfusate containing total alkaloids of Sophora fructus for treating dairy cow mastitis and endometritis and preparation method thereof
  • Traditional Chinese medicine perfusate containing total alkaloids of Sophora fructus for treating dairy cow mastitis and endometritis and preparation method thereof
  • Traditional Chinese medicine perfusate containing total alkaloids of Sophora fructus for treating dairy cow mastitis and endometritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] The preparation method of the traditional Chinese medicine perfusate containing total alkaloids of Sophora Sophorae comprises the following steps:

[0101] 1) Grind the seeds of Sophora sophora, add ethanol aqueous solution for ultrasonic extraction, recover ethanol after filtration, add 2% hydrochloric acid to adjust the pH, add ether to wash twice, obtain the filtrate precipitate, then add chloroform to extract the precipitate, recover chloroform under reduced pressure to obtain Sophora sophora total alkali;

[0102] 2) Add water for injection to 3 g of the total alkaloids of Sophora sophora obtained in step 1) to make the volume to 100 ml, sterilize with circulating steam for 30 minutes, and fill under aseptic conditions to obtain the finished traditional Chinese medicine perfusate.

Embodiment 2

[0104] The preparation method of the traditional Chinese medicine perfusate containing total alkaloids of Sophora Sophorae comprises the following steps:

[0105] 1) Grind the seeds of Sophora sophora, add ethanol aqueous solution for ultrasonic extraction, recover ethanol after filtration, add 2% hydrochloric acid to adjust the pH, add ether to wash twice, obtain the filtrate precipitate, then add chloroform to extract the precipitate, recover chloroform under reduced pressure to obtain Sophora sophora total alkali;

[0106] 2) Add water for injection to 8 g of total alkaloids obtained in step 1) to make the volume to 100 ml, sterilize with circulating steam for 40 min, and fill under aseptic conditions to obtain the finished traditional Chinese medicine perfusate.

Embodiment 3

[0108] The preparation method of the traditional Chinese medicine perfusate containing total alkaloids of Sophora Sophorae comprises the following steps:

[0109] 1) Grind the seeds of Sophora sophora, add ethanol aqueous solution for ultrasonic extraction, recover ethanol after filtration, add 2% hydrochloric acid to adjust the pH, add ether to wash twice, obtain the filtrate precipitate, then add chloroform to extract the precipitate, recover chloroform under reduced pressure to obtain Sophora sophora total alkali;

[0110] 2) Add water for injection to 6 g of the total alkaloids of Sophora sophorae obtained in step 1) to make the volume to 100 ml, sterilize with circulating steam for 35 minutes, and fill under aseptic conditions to obtain the finished traditional Chinese medicine perfusate.

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PUM

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Abstract

The invention discloses a sophora alopecuroide total alkaloid-containing traditional Chinese medicine perfusion fluid, which is quick in becoming effective, low in toxicity, easy in metabolism and free of residues and is used for treating bovine mastitis and endometritis as well as a preparation method of the perfusion fluid. The sophora alopecuroide total alkaloid-containing traditional Chinese medicine perfusion fluid for treating bovine mastitis and endometritis has the beneficial effects of being small in toxic or side effect and unlikely to generate resistance to drugs by adopting the sophora alopecuroide total alkaloid perfusion fluid as the pure natural medicine, as well as remarkably saving the cost and reducing abandoned milk loss; and moreover, traditional Chinese medicine therapy lays emphasis on nursing and is beneficial to recovering the integral function and body condition. The sophora alopecuroide total alkaloid-containing traditional Chinese medicine perfusion fluid has an extensive development prospect in treating the bovine mastitis.

Description

technical field [0001] The invention relates to the field of application of traditional Chinese medicines, in particular to a traditional Chinese medicine perfusate containing total alkaloids of Sophora grandis for treating cow mastitis and endometritis. Background technique [0002] Sophora sophora is a perennial leguminous herb, the dried whole grass and seeds of sophora sophora. Bitter beans are widely distributed in Gansu, Ningxia, Xinjiang, Tibet, Inner Mongolia and other places. The whole plant is harvested in summer, and the seeds are harvested in spring and dried. The whole plant is used raw and the seeds are fried. In recent years, the country has listed Sophora alopecuroides as one of the six authentic medicinal materials under key protection, and incorporated it into the national action plan for the modernization of traditional Chinese medicine science and technology industry, which has made great progress in the construction of production bases and in-depth dev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K9/00A61P15/00A61P15/14
Inventor 周玉岩陶蕾梁剑平张志清逯佩凤代珍青
Owner GUANGDONG HINAPHARM PHARMA CO LTD
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