A kind of dengue virus degenerate vaccine and its application

A dengue virus and vaccine technology, applied in the direction of antiviral immunoglobulin, application, viral peptides, etc., can solve the problem that type 2 dengue fever virus strains cannot protect, the protection effect of specific epidemic strains is not good, and the overall effect is not ideal and other problems, to achieve the effects of low mammalian cell expression system, cost control, and antibody-dependent enhancement
CN103193870BInactive Publication Date: 2014-10-22ARMY MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ARMY MEDICAL UNIV
Publication Date
2014-10-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a dengue virus degeneration vaccine and application thereof. The amino acid sequence of the dengue virus degeneration vaccine is shown as SEQ ID NO.2; the amino acid sequence of the dengue virus degeneration vaccine contains an antigen peptide fragment, a dengue virus envelope glycoprotein EDIII region, a virus virulence related gene neutralizing epitope, a beta lamella and Loop amino acid, wherein the antigen peptide fragment is determined after sequence comparison analysis is carried out on a dengue virus representative strain which respectively contains serotypes 1,2,3,4; and the beta lamella retains a basic structure which forms the dengue virus envelope glycoprotein EDIII region. The dengue virus degeneration vaccine disclosed by the invention can be used for immunizing an organism, stimulating the organism to generate humoral immunity response and preventing the dengue virus infectious diseases.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a dengue virus degenerate vaccine and its preparation method and application. Background technique

[0002] Dengue virus (DV) is an enveloped single-stranded positive-sense RNA virus belonging to the genus Flaviviridae. It uses mosquitoes as a vector and is widely prevalent in tropical and subtropical regions. Human dengue fever (classical dengue fever, DF) and dengue hemorrhagic fever / dengue shock syndrome (dengue hemorrhagic fever / dengue shock syndrome, DHF / DSS) caused by DV infection seriously endanger human health. There are 2.5 to 3 billion people living in endemic areas in the world, and more than 100 million people are infected every year. DHF cases are about 500,000, and the mortality rate is 5 to 20%. If the treatment is not timely, it can reach 50%. In recent years, with many reasons such as global warming, population flow, ecological environment deteri...

Claims

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