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Traditional Chinese medicine extractive and preparation method thereof

A technology of extracts and natural medicines, used in drug combinations, pharmaceutical formulations, antitumor drugs, etc., can solve the problems of patients with dehydration, acid-base balance disorders, malnutrition, etc., to increase the inhibitory effect, enhance the inhibitory effect, and achieve good synergy effect of action

Inactive Publication Date: 2013-07-24
阚兆云
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AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, etc., the incidence of chemotherapy-related diarrhea has increased year by year, and if active treatment is not carried out, it is easy to cause Dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc. in patients not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Therefore, effective treatment of chemotherapy-related diarrhea has become a An important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Traditional Chinese medicine extractive and preparation method thereof
  • Traditional Chinese medicine extractive and preparation method thereof

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Experimental program
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Effect test

Embodiment approach

[0030] The first step: preparation of various extracts

[0031] (1) Preparation of Coptidis Phellodendron Phellodendri Decoction Concentrated Extract

[0032] According to the compatibility ratio of 1:1 or 1-4:1, take Coptis chinensis and Cortex Phellodendri, soak in 10 times the amount of distilled water for 1 hour, heat and decoct on an electric stove with asbestos net for 1 hour, filter with silk cloth, save the filtrate, add the dregs 6 times of distilled water, soaking, decocting, and filtering in the same way, mixing the two filtrates, heating and concentrating to a small volume, filtering with an ultrafiltration membrane, and drying under reduced pressure at 70°C for 36 hours in a vacuum drying oven to obtain a brown-yellow powder.

[0033] (2) preparation of berberine

[0034] Coptis rhizome is crushed, add ethanol, heat and reflux in water bath for 0.5h, suction filter, repeat the above operation twice for the filter residue, combine the filtrate, recover ethanol und...

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Abstract

The invention relates to a natural medicine composition as well as a preparation method and application thereof in preparation of medicines for reducing toxicity and enhancing efficacy in cancer chemotherapy. The natural medicine composition is prepared from an extractive prepared by decocting and concentrating coptidis rhizoma and cortex phellodendri, berberine, and an extractive of cortex phellodendri and ethyl acetate in a ratio of (2-6): (3-9): (1-5). The composition has very good curative effect on cancer chemotherapy-associated diarrhea and simultaneously has a synergic effect on the cancer chemotherapy.

Description

technical field [0001] The present invention relates to a kind of natural medicine composition, more specifically relate to a kind of natural medicine composition that is made up of Coptidis Rhizoma Cortex Phellodendri decoction concentrated extract, berberine and Phellodendron Phellodendron ethyl acetate extract, the preparation method of this natural medicine composition and Use of the natural medicine composition for preparing medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs, whether used alone or in combination, can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy i...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P35/00A61K31/4375
Inventor 阚兆云
Owner 阚兆云